Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386070410> ?p ?o ?g. }
- W4386070410 abstract "Identifying pathogenetic variants and inferring their impact on protein–protein interactions sheds light on their functional consequences on diseases. Limited by the availability of experimental data on the consequences of protein interaction, most existing methods focus on building models to predict changes in protein binding affinity. Here, we introduced MIPPI, an end-to-end, interpretable transformer-based deep learning model that learns features directly from sequences by leveraging the interaction data from IMEx. MIPPI was specifically trained to determine the types of variant impact (increasing, decreasing, disrupting, and no effect) on protein–protein interactions. We demonstrate the accuracy of MIPPI and provide interpretation through the analysis of learned attention weights, which exhibit correlations with the amino acids interacting with the variant. Moreover, we showed the practicality of MIPPI in prioritizing de novo mutations associated with complex neurodevelopmental disorders and the potential to determine the pathogenic and driving mutations. Finally, we experimentally validated the functional impact of several variants identified in patients with such disorders. Overall, MIPPI emerges as a versatile, robust, and interpretable model, capable of effectively predicting mutation impacts on protein–protein interactions and facilitating the discovery of clinically actionable variants." @default.
- W4386070410 created "2023-08-23" @default.
- W4386070410 creator A5002294425 @default.
- W4386070410 creator A5018559515 @default.
- W4386070410 creator A5019386958 @default.
- W4386070410 creator A5025950349 @default.
- W4386070410 creator A5041110468 @default.
- W4386070410 creator A5042484728 @default.
- W4386070410 creator A5047609717 @default.
- W4386070410 creator A5048840363 @default.
- W4386070410 creator A5082428303 @default.
- W4386070410 creator A5084854649 @default.
- W4386070410 creator A5091161457 @default.
- W4386070410 date "2023-01-01" @default.
- W4386070410 modified "2023-09-23" @default.
- W4386070410 title "Inferring the Effects of Protein Variants on Protein–protein Interactions with Interpretable Transformer Representations" @default.
- W4386070410 cites W1498436455 @default.
- W4386070410 cites W1563940013 @default.
- W4386070410 cites W1577581905 @default.
- W4386070410 cites W1611787727 @default.
- W4386070410 cites W1677182931 @default.
- W4386070410 cites W1972765844 @default.
- W4386070410 cites W1975580333 @default.
- W4386070410 cites W2011538856 @default.
- W4386070410 cites W2023490488 @default.
- W4386070410 cites W2059145105 @default.
- W4386070410 cites W2064675550 @default.
- W4386070410 cites W2072118242 @default.
- W4386070410 cites W2076048958 @default.
- W4386070410 cites W2085017439 @default.
- W4386070410 cites W2103459989 @default.
- W4386070410 cites W2109553965 @default.
- W4386070410 cites W2111663421 @default.
- W4386070410 cites W2115195765 @default.
- W4386070410 cites W2117541321 @default.
- W4386070410 cites W2130479394 @default.
- W4386070410 cites W2137886330 @default.
- W4386070410 cites W2143238378 @default.
- W4386070410 cites W2147001911 @default.
- W4386070410 cites W2148143831 @default.
- W4386070410 cites W2149580316 @default.
- W4386070410 cites W2156880972 @default.
- W4386070410 cites W2158714788 @default.
- W4386070410 cites W2160995259 @default.
- W4386070410 cites W2162259397 @default.
- W4386070410 cites W2169243280 @default.
- W4386070410 cites W2169816095 @default.
- W4386070410 cites W2173918725 @default.
- W4386070410 cites W2188528468 @default.
- W4386070410 cites W2194775991 @default.
- W4386070410 cites W2345331290 @default.
- W4386070410 cites W2361260139 @default.
- W4386070410 cites W2558879065 @default.
- W4386070410 cites W2564185320 @default.
- W4386070410 cites W2590688707 @default.
- W4386070410 cites W2598318056 @default.
- W4386070410 cites W2613362156 @default.
- W4386070410 cites W2626606138 @default.
- W4386070410 cites W2770738909 @default.
- W4386070410 cites W2782153240 @default.
- W4386070410 cites W2805031335 @default.
- W4386070410 cites W2905452503 @default.
- W4386070410 cites W2911964244 @default.
- W4386070410 cites W2928665623 @default.
- W4386070410 cites W2933097785 @default.
- W4386070410 cites W2945403072 @default.
- W4386070410 cites W2949787032 @default.
- W4386070410 cites W2949814610 @default.
- W4386070410 cites W2953103783 @default.
- W4386070410 cites W2955704392 @default.
- W4386070410 cites W2963351448 @default.
- W4386070410 cites W2981772515 @default.
- W4386070410 cites W2994204335 @default.
- W4386070410 cites W2997930593 @default.
- W4386070410 cites W2999155487 @default.
- W4386070410 cites W3007500173 @default.
- W4386070410 cites W3010338076 @default.
- W4386070410 cites W3015602557 @default.
- W4386070410 cites W3049396514 @default.
- W4386070410 cites W3093053585 @default.
- W4386070410 cites W3102476541 @default.
- W4386070410 cites W3124828689 @default.
- W4386070410 cites W3177828909 @default.
- W4386070410 cites W3202105508 @default.
- W4386070410 cites W4200456566 @default.
- W4386070410 cites W4206940890 @default.
- W4386070410 cites W4256561644 @default.
- W4386070410 cites W4312827846 @default.
- W4386070410 doi "https://doi.org/10.34133/research.0219" @default.
- W4386070410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37701056" @default.
- W4386070410 hasPublicationYear "2023" @default.
- W4386070410 type Work @default.
- W4386070410 citedByCount "0" @default.
- W4386070410 crossrefType "journal-article" @default.
- W4386070410 hasAuthorship W4386070410A5002294425 @default.
- W4386070410 hasAuthorship W4386070410A5018559515 @default.
- W4386070410 hasAuthorship W4386070410A5019386958 @default.
- W4386070410 hasAuthorship W4386070410A5025950349 @default.
- W4386070410 hasAuthorship W4386070410A5041110468 @default.
- W4386070410 hasAuthorship W4386070410A5042484728 @default.