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- W4386071037 abstract "Neurofilaments (NFs) are not only important for axonal integrity and nerve conduction in large myelinated axons but they are also thought to be crucial for receptor and synaptic functioning. Therefore, NFs may play a critical role in cognitive functions, as cognitive processes are known to depend on synaptic integrity and are modulated by dopaminergic signaling. Here, we present a theory-driven interdisciplinary approach that NFs may link inflammation, neurodegeneration, and cognitive functions. We base our hypothesis on a wealth of evidence suggesting a causal link between inflammation and neurodegeneration and between these two and cognitive decline (see Fig. 1), also taking dopaminergic signaling into account. We conclude that NFs may not only serve as biomarkers for inflammatory, neurodegenerative, and cognitive processes but also represent a potential mechanical hinge between them, moreover, they may even have predictive power regarding future cognitive decline. In addition, we advocate the use of both NFs and MRI parameters, as their synthesis offers the opportunity to individualize medical treatment by providing a comprehensive view of underlying disease activity in neurological diseases. Since our society will become significantly older in the upcoming years and decades, maintaining cognitive functions and healthy aging will play an important role. Thanks to technological advances in recent decades, NFs could serve as a rapid, noninvasive, and relatively inexpensive early warning system to identify individuals at increased risk for cognitive decline and could facilitate the management of cognitive dysfunctions across the lifespan." @default.
- W4386071037 created "2023-08-23" @default.
- W4386071037 creator A5044375884 @default.
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- W4386071037 creator A5089131482 @default.
- W4386071037 date "2023-09-01" @default.
- W4386071037 modified "2023-10-10" @default.
- W4386071037 title "Neurofilaments – Small proteins of physiological significance and predictive power for future neurodegeneration and cognitive decline across the life span" @default.
- W4386071037 cites W1496107582 @default.
- W4386071037 cites W1516122098 @default.
- W4386071037 cites W1526172542 @default.
- W4386071037 cites W1547362808 @default.
- W4386071037 cites W1607206274 @default.
- W4386071037 cites W1828576284 @default.
- W4386071037 cites W1860841401 @default.
- W4386071037 cites W1879175929 @default.
- W4386071037 cites W1889028771 @default.
- W4386071037 cites W1947131268 @default.
- W4386071037 cites W1966162768 @default.
- W4386071037 cites W1969409914 @default.
- W4386071037 cites W1972877746 @default.
- W4386071037 cites W1973676211 @default.
- W4386071037 cites W1974535033 @default.
- W4386071037 cites W1974924674 @default.
- W4386071037 cites W1977742425 @default.
- W4386071037 cites W1978567629 @default.
- W4386071037 cites W1985782855 @default.
- W4386071037 cites W1989369404 @default.
- W4386071037 cites W1991725112 @default.
- W4386071037 cites W1997230335 @default.
- W4386071037 cites W1997552709 @default.
- W4386071037 cites W2010168445 @default.
- W4386071037 cites W2010397126 @default.
- W4386071037 cites W2014447462 @default.
- W4386071037 cites W2020223855 @default.
- W4386071037 cites W2020935778 @default.
- W4386071037 cites W2030772730 @default.
- W4386071037 cites W2037944537 @default.
- W4386071037 cites W2038392177 @default.
- W4386071037 cites W2043464691 @default.
- W4386071037 cites W2044444144 @default.
- W4386071037 cites W2046270099 @default.
- W4386071037 cites W2046983320 @default.
- W4386071037 cites W2047402066 @default.
- W4386071037 cites W2050134774 @default.
- W4386071037 cites W2051946499 @default.
- W4386071037 cites W2056103023 @default.
- W4386071037 cites W2057173639 @default.
- W4386071037 cites W2057824887 @default.
- W4386071037 cites W2061671780 @default.
- W4386071037 cites W2063699514 @default.
- W4386071037 cites W2065422132 @default.
- W4386071037 cites W2067975928 @default.
- W4386071037 cites W2069604660 @default.
- W4386071037 cites W2070558694 @default.
- W4386071037 cites W2075058580 @default.
- W4386071037 cites W2076284955 @default.
- W4386071037 cites W2076362385 @default.
- W4386071037 cites W2080224067 @default.
- W4386071037 cites W2081164888 @default.
- W4386071037 cites W2082402714 @default.
- W4386071037 cites W2082533002 @default.
- W4386071037 cites W2084002557 @default.
- W4386071037 cites W2087243986 @default.
- W4386071037 cites W2088350637 @default.
- W4386071037 cites W2089701649 @default.
- W4386071037 cites W2092927038 @default.
- W4386071037 cites W2094063063 @default.
- W4386071037 cites W2094712734 @default.
- W4386071037 cites W2104183725 @default.
- W4386071037 cites W2105897659 @default.
- W4386071037 cites W2115585096 @default.
- W4386071037 cites W2117372015 @default.
- W4386071037 cites W2122880716 @default.
- W4386071037 cites W2128948218 @default.
- W4386071037 cites W2129053667 @default.
- W4386071037 cites W2129470474 @default.
- W4386071037 cites W2130527924 @default.
- W4386071037 cites W2130788353 @default.
- W4386071037 cites W2133652987 @default.
- W4386071037 cites W2134044586 @default.
- W4386071037 cites W2137938217 @default.
- W4386071037 cites W2143076441 @default.
- W4386071037 cites W2145630925 @default.
- W4386071037 cites W2149298826 @default.
- W4386071037 cites W2149516565 @default.
- W4386071037 cites W2150429740 @default.
- W4386071037 cites W2151010780 @default.
- W4386071037 cites W2152060400 @default.
- W4386071037 cites W2154845408 @default.
- W4386071037 cites W2157203036 @default.
- W4386071037 cites W2157586156 @default.
- W4386071037 cites W2159616908 @default.
- W4386071037 cites W2163526164 @default.
- W4386071037 cites W2167630456 @default.
- W4386071037 cites W2167702959 @default.