FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386071262> ?p ?o ?g. }

• W4386071262 endingPage "117073" @default.
• W4386071262 startingPage "117073" @default.
• W4386071262 abstract "Diabetic nephropathy (DN) was a major cause of end-stage renal failure and a common microvascular complication in patients with diabetes mellitus (DM). Acteoside (ACT) was the main ingredient extracted from the leaves of Rehmannia glutinosa, which had the functions of entering the lung, moisturizing the skin and relieving itching, nourishing yin and tonifying the kidney, cooling blood, and stopping bleeding. ACT had attracted worldwide interest because of its therapeutic effects on DM and its complications.To clarify the metabolic profiles and targets of ACT in db/db mice based on metabolomics and network pharmacology studies.Db/db mice were used to observe the biochemical indices and histopathological changes in the kidney to evaluate the pharmacological effects of ACT on DN. Untargeted metabolomics studies were performed to investigate by UHPLC-LTQ-Orbitrap MS on urine, serum, and kidney samples. The key targets and pathways were analyzed by network pharmacology. For the pathways enriched by untargeted metabolomics, targeted metabolomics by UHPLC-QQQ-MS/MS was performed in kidney samples for validation. Sensitive biomarkers in kidney samples were evaluated. The effect of ACT on the improvement of DN from the perspective of metabolism of small molecules in vivo was described.ACT could delay the progression of DN and improve the degree of histopathological damage to the kidney. The pathways were focused on amino acid metabolism by untargeted metabolomics. Through network pharmacology analysis, the effect pathways were related to signal transduction, carbohydrate, lipid, amino acid metabolism and mainly affected the endocrine and immune systems. Amino acid metabolism was disturbed in the kidney of db/db mice, which could be callback by ACT, such as tryptophan, glutamine, cysteine, leucine, threonine, proline, phenylalanine, histidine, serine, arginine, asparagine by targeted metabolomics.In conclusion, this study provided strong support for ACT on DN treatment in clinics. Meanwhile, the Rehmannia glutinosa was used fully to raise the income level of farmers economically, while achieving the social benefit of empowering rural revitalization." @default.
• W4386071262 created "2023-08-23" @default.
• W4386071262 creator A5001627310 @default.
• W4386071262 creator A5002860009 @default.
• W4386071262 creator A5011390933 @default.
• W4386071262 creator A5030521144 @default.
• W4386071262 creator A5033205455 @default.
• W4386071262 creator A5034493918 @default.
• W4386071262 creator A5041997172 @default.
• W4386071262 creator A5049763932 @default.
• W4386071262 creator A5057049857 @default.
• W4386071262 creator A5070825498 @default.
• W4386071262 creator A5076211418 @default.
• W4386071262 creator A5076824143 @default.
• W4386071262 creator A5080815296 @default.
• W4386071262 creator A5082117229 @default.
• W4386071262 creator A5086326013 @default.
• W4386071262 date "2024-01-01" @default.
• W4386071262 modified "2023-09-23" @default.
• W4386071262 title "Altered metabolic profiles and targets relevant to the protective effect of acteoside on diabetic nephropathy in db/db mice based on metabolomics and network pharmacology studies" @default.
• W4386071262 cites W1991936623 @default.
• W4386071262 cites W2004376675 @default.
• W4386071262 cites W2017771330 @default.
• W4386071262 cites W2041704795 @default.
• W4386071262 cites W2048456055 @default.
• W4386071262 cites W2074471647 @default.
• W4386071262 cites W2113664327 @default.
• W4386071262 cites W2136490577 @default.
• W4386071262 cites W2164367548 @default.
• W4386071262 cites W2299919642 @default.
• W4386071262 cites W2472425605 @default.
• W4386071262 cites W2474747771 @default.
• W4386071262 cites W2611425558 @default.
• W4386071262 cites W2619019810 @default.
• W4386071262 cites W2766536598 @default.
• W4386071262 cites W2767891136 @default.
• W4386071262 cites W2789052267 @default.
• W4386071262 cites W2790580419 @default.
• W4386071262 cites W2790748698 @default.
• W4386071262 cites W2807586373 @default.
• W4386071262 cites W2807643570 @default.
• W4386071262 cites W2890641629 @default.
• W4386071262 cites W2898599254 @default.
• W4386071262 cites W2900569176 @default.
• W4386071262 cites W2914244078 @default.
• W4386071262 cites W2946412700 @default.
• W4386071262 cites W2968306995 @default.
• W4386071262 cites W2991077064 @default.
• W4386071262 cites W3038455869 @default.
• W4386071262 cites W3093562579 @default.
• W4386071262 cites W3134106390 @default.
• W4386071262 cites W3164968925 @default.
• W4386071262 cites W3171540867 @default.
• W4386071262 cites W3210331473 @default.
• W4386071262 cites W4244554915 @default.
• W4386071262 cites W4252005668 @default.
• W4386071262 cites W4287377519 @default.
• W4386071262 cites W4295123939 @default.
• W4386071262 cites W4308255188 @default.
• W4386071262 cites W4327653799 @default.
• W4386071262 doi "https://doi.org/10.1016/j.jep.2023.117073" @default.
• W4386071262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37619856" @default.
• W4386071262 hasPublicationYear "2024" @default.
• W4386071262 type Work @default.
• W4386071262 citedByCount "0" @default.
• W4386071262 crossrefType "journal-article" @default.
• W4386071262 hasAuthorship W4386071262A5001627310 @default.
• W4386071262 hasAuthorship W4386071262A5002860009 @default.
• W4386071262 hasAuthorship W4386071262A5011390933 @default.
• W4386071262 hasAuthorship W4386071262A5030521144 @default.
• W4386071262 hasAuthorship W4386071262A5033205455 @default.
• W4386071262 hasAuthorship W4386071262A5034493918 @default.
• W4386071262 hasAuthorship W4386071262A5041997172 @default.
• W4386071262 hasAuthorship W4386071262A5049763932 @default.
• W4386071262 hasAuthorship W4386071262A5057049857 @default.
• W4386071262 hasAuthorship W4386071262A5070825498 @default.
• W4386071262 hasAuthorship W4386071262A5076211418 @default.
• W4386071262 hasAuthorship W4386071262A5076824143 @default.
• W4386071262 hasAuthorship W4386071262A5080815296 @default.
• W4386071262 hasAuthorship W4386071262A5082117229 @default.
• W4386071262 hasAuthorship W4386071262A5086326013 @default.
• W4386071262 hasConcept C126322002 @default.
• W4386071262 hasConcept C134018914 @default.
• W4386071262 hasConcept C185592680 @default.
• W4386071262 hasConcept C192989942 @default.
• W4386071262 hasConcept C21565614 @default.
• W4386071262 hasConcept C2779922275 @default.
• W4386071262 hasConcept C2780091579 @default.
• W4386071262 hasConcept C2781184683 @default.
• W4386071262 hasConcept C4733338 @default.
• W4386071262 hasConcept C555293320 @default.
• W4386071262 hasConcept C60644358 @default.
• W4386071262 hasConcept C62231903 @default.
• W4386071262 hasConcept C71924100 @default.
• W4386071262 hasConcept C86803240 @default.
• W4386071262 hasConcept C98274493 @default.
• W4386071262 hasConceptScore W4386071262C126322002 @default.
• W4386071262 hasConceptScore W4386071262C134018914 @default.

• next