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- W4386073102 endingPage "2174" @default.
- W4386073102 startingPage "2174" @default.
- W4386073102 abstract "Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-amorphous systems, are a result of the combination of an active pharmaceutical ingredient (API) with a pharmaceutically acceptable co-former. These solid forms can enhance the physicochemical and pharmacokinetic properties of APIs, making them increasingly interesting and important in recent decades. Nevertheless, predicting the formation of API multicomponent solid forms in the early stages of formulation development can be challenging, as it often requires significant time and resources. To address this, empirical and computational methods have been developed to help screen for potential co-formers more efficiently and accurately, thus reducing the number of laboratory experiments needed. This review provides a comprehensive overview of current screening and prediction methods for the formation of API multicomponent solid forms, covering both crystalline states (co-crystals and salts) and amorphous forms (co-amorphous). Furthermore, it discusses recent advances and emerging trends in prediction methods, with a particular focus on artificial intelligence." @default.
- W4386073102 created "2023-08-23" @default.
- W4386073102 creator A5006553874 @default.
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- W4386073102 creator A5063987634 @default.
- W4386073102 creator A5073171054 @default.
- W4386073102 creator A5074144806 @default.
- W4386073102 date "2023-08-22" @default.
- W4386073102 modified "2023-10-17" @default.
- W4386073102 title "Recent Advances in Co-Former Screening and Formation Prediction of Multicomponent Solid Forms of Low Molecular Weight Drugs" @default.
- W4386073102 cites W1498305210 @default.
- W4386073102 cites W1604186570 @default.
- W4386073102 cites W1697337825 @default.
- W4386073102 cites W1741634432 @default.
- W4386073102 cites W1964855514 @default.
- W4386073102 cites W1970977603 @default.
- W4386073102 cites W1972220131 @default.
- W4386073102 cites W1985788927 @default.
- W4386073102 cites W1992478909 @default.
- W4386073102 cites W1995008519 @default.
- W4386073102 cites W2001059239 @default.
- W4386073102 cites W2003964439 @default.
- W4386073102 cites W2005574399 @default.
- W4386073102 cites W2007068681 @default.
- W4386073102 cites W2007666693 @default.
- W4386073102 cites W2009032263 @default.
- W4386073102 cites W2010685353 @default.
- W4386073102 cites W2011134011 @default.
- W4386073102 cites W2012254584 @default.
- W4386073102 cites W2020025895 @default.
- W4386073102 cites W2027411654 @default.
- W4386073102 cites W2031195045 @default.
- W4386073102 cites W2034554788 @default.
- W4386073102 cites W2053585042 @default.
- W4386073102 cites W2055803559 @default.
- W4386073102 cites W2056404198 @default.
- W4386073102 cites W2057448579 @default.
- W4386073102 cites W2058592151 @default.
- W4386073102 cites W2063422818 @default.
- W4386073102 cites W2063548340 @default.
- W4386073102 cites W2063819327 @default.
- W4386073102 cites W2066502834 @default.
- W4386073102 cites W2067002519 @default.
- W4386073102 cites W2079268284 @default.
- W4386073102 cites W2082830729 @default.
- W4386073102 cites W2086130951 @default.
- W4386073102 cites W2097481983 @default.
- W4386073102 cites W2098222684 @default.
- W4386073102 cites W2098376669 @default.
- W4386073102 cites W2102060985 @default.
- W4386073102 cites W2109585060 @default.
- W4386073102 cites W2123968367 @default.
- W4386073102 cites W2128745537 @default.
- W4386073102 cites W2132795750 @default.
- W4386073102 cites W2135824076 @default.
- W4386073102 cites W2142802964 @default.
- W4386073102 cites W2155505618 @default.
- W4386073102 cites W2155692480 @default.
- W4386073102 cites W2169998904 @default.
- W4386073102 cites W2275944058 @default.
- W4386073102 cites W2297802647 @default.
- W4386073102 cites W2318118297 @default.
- W4386073102 cites W2324296362 @default.
- W4386073102 cites W2325045271 @default.
- W4386073102 cites W2508302103 @default.
- W4386073102 cites W2524413988 @default.
- W4386073102 cites W2593883665 @default.
- W4386073102 cites W2599801457 @default.
- W4386073102 cites W2625559662 @default.
- W4386073102 cites W2733090315 @default.
- W4386073102 cites W2766983743 @default.
- W4386073102 cites W2767187922 @default.
- W4386073102 cites W2769166747 @default.
- W4386073102 cites W2774535559 @default.
- W4386073102 cites W2786222357 @default.
- W4386073102 cites W2797502872 @default.
- W4386073102 cites W2802043492 @default.
- W4386073102 cites W2804154151 @default.
- W4386073102 cites W2806781349 @default.
- W4386073102 cites W2886138501 @default.
- W4386073102 cites W2911120881 @default.
- W4386073102 cites W2947141843 @default.
- W4386073102 cites W2947550602 @default.
- W4386073102 cites W2978583373 @default.
- W4386073102 cites W2980102087 @default.
- W4386073102 cites W2991188715 @default.
- W4386073102 cites W2993187789 @default.
- W4386073102 cites W2998714878 @default.
- W4386073102 cites W3003227173 @default.
- W4386073102 cites W3010781663 @default.
- W4386073102 cites W3014454873 @default.
- W4386073102 cites W3045040003 @default.
- W4386073102 cites W3048861028 @default.
- W4386073102 cites W3082542432 @default.
- W4386073102 cites W3087459979 @default.
- W4386073102 cites W3087471863 @default.
- W4386073102 cites W3088588908 @default.
- W4386073102 cites W3092196647 @default.