Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386073973> ?p ?o ?g. }
- W4386073973 endingPage "13070" @default.
- W4386073973 startingPage "13070" @default.
- W4386073973 abstract "Before the late 1980s, ideas around how the lipophilic phytocannabinoids might be working involved membranes and bioenergetics as these disciplines were in vogue. However, as interest in genetics and pharmacology grew, interest in mitochondria (and membranes) waned. The discovery of the cognate receptor for tetrahydrocannabinol (THC) led to the classification of the endocannabinoid system (ECS) and the conjecture that phytocannabinoids might be working through this system. However, the how and the why they might be beneficial, especially for compounds like CBD, remains unclear. Given the centrality of membranes and mitochondria in complex organisms, and their evolutionary heritage from the beginnings of life, revisiting phytocannabinoid action in this light could be enlightening. For example, life can be described as a self-organising and replicating far from equilibrium dissipating system, which is defined by the movement of charge across a membrane. Hence the building evidence, at least in animals, that THC and CBD modulate mitochondrial function could be highly informative. In this paper, we offer a unique perspective to the question, why and how do compounds like CBD potentially work as medicines in so many different conditions? The answer, we suggest, is that they can modulate membrane fluidity in a number of ways and thus dissipation and engender homeostasis, particularly under stress. To understand this, we need to embrace origins of life theories, the role of mitochondria in plants and explanations of disease and ageing from an adaptive thermodynamic perspective, as well as quantum mechanics." @default.
- W4386073973 created "2023-08-23" @default.
- W4386073973 creator A5005307132 @default.
- W4386073973 creator A5021196507 @default.
- W4386073973 creator A5057380504 @default.
- W4386073973 date "2023-08-22" @default.
- W4386073973 modified "2023-09-29" @default.
- W4386073973 title "Informing the Cannabis Conjecture: From Life’s Beginnings to Mitochondria, Membranes and the Electrome—A Review" @default.
- W4386073973 cites W1166458116 @default.
- W4386073973 cites W1493509581 @default.
- W4386073973 cites W1496162310 @default.
- W4386073973 cites W1506443814 @default.
- W4386073973 cites W1573994843 @default.
- W4386073973 cites W1832918544 @default.
- W4386073973 cites W1942622409 @default.
- W4386073973 cites W1964126982 @default.
- W4386073973 cites W1964205669 @default.
- W4386073973 cites W1965050344 @default.
- W4386073973 cites W1973618134 @default.
- W4386073973 cites W1974694396 @default.
- W4386073973 cites W1976770854 @default.
- W4386073973 cites W1978027075 @default.
- W4386073973 cites W1980923499 @default.
- W4386073973 cites W1981229332 @default.
- W4386073973 cites W1981259120 @default.
- W4386073973 cites W1981748085 @default.
- W4386073973 cites W1982200474 @default.
- W4386073973 cites W1983832155 @default.
- W4386073973 cites W1985538633 @default.
- W4386073973 cites W1985800268 @default.
- W4386073973 cites W1986405853 @default.
- W4386073973 cites W1986530960 @default.
- W4386073973 cites W1987447550 @default.
- W4386073973 cites W1991044118 @default.
- W4386073973 cites W1992661831 @default.
- W4386073973 cites W1995392199 @default.
- W4386073973 cites W1997243387 @default.
- W4386073973 cites W1997696700 @default.
- W4386073973 cites W2001221194 @default.
- W4386073973 cites W2001808017 @default.
- W4386073973 cites W2002118562 @default.
- W4386073973 cites W2008841747 @default.
- W4386073973 cites W2009864558 @default.
- W4386073973 cites W2009866554 @default.
- W4386073973 cites W2014742651 @default.
- W4386073973 cites W2019188215 @default.
- W4386073973 cites W2020817051 @default.
- W4386073973 cites W2026807011 @default.
- W4386073973 cites W2029441669 @default.
- W4386073973 cites W2029790055 @default.
- W4386073973 cites W2030623240 @default.
- W4386073973 cites W2032354328 @default.
- W4386073973 cites W2032578724 @default.
- W4386073973 cites W2033673006 @default.
- W4386073973 cites W2036229829 @default.
- W4386073973 cites W2037600884 @default.
- W4386073973 cites W2039175679 @default.
- W4386073973 cites W2039190163 @default.
- W4386073973 cites W2040336212 @default.
- W4386073973 cites W2041000367 @default.
- W4386073973 cites W2041061895 @default.
- W4386073973 cites W2044513817 @default.
- W4386073973 cites W2044924691 @default.
- W4386073973 cites W2045162664 @default.
- W4386073973 cites W2053022803 @default.
- W4386073973 cites W2057911815 @default.
- W4386073973 cites W2059744535 @default.
- W4386073973 cites W2060036779 @default.
- W4386073973 cites W2060137033 @default.
- W4386073973 cites W2062671133 @default.
- W4386073973 cites W2066057252 @default.
- W4386073973 cites W2066519414 @default.
- W4386073973 cites W2066762257 @default.
- W4386073973 cites W2067940639 @default.
- W4386073973 cites W2072319820 @default.
- W4386073973 cites W2073336353 @default.
- W4386073973 cites W2073513307 @default.
- W4386073973 cites W2074062695 @default.
- W4386073973 cites W2075431048 @default.
- W4386073973 cites W2076638061 @default.
- W4386073973 cites W2077438524 @default.
- W4386073973 cites W207757059 @default.
- W4386073973 cites W2078027533 @default.
- W4386073973 cites W2078340755 @default.
- W4386073973 cites W2080124817 @default.
- W4386073973 cites W2081303452 @default.
- W4386073973 cites W2081538168 @default.
- W4386073973 cites W2090277199 @default.
- W4386073973 cites W2091959680 @default.
- W4386073973 cites W2092311021 @default.
- W4386073973 cites W2095350647 @default.
- W4386073973 cites W2096237847 @default.
- W4386073973 cites W2097207500 @default.
- W4386073973 cites W2101676131 @default.
- W4386073973 cites W2109321075 @default.
- W4386073973 cites W2109692759 @default.
- W4386073973 cites W2111416302 @default.
- W4386073973 cites W2112384117 @default.