Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386074294> ?p ?o ?g. }
- W4386074294 endingPage "1791" @default.
- W4386074294 startingPage "1791" @default.
- W4386074294 abstract "Nucleoporins (NUPs) are proteins that comprise the nuclear pore complexes (NPCs). The NPC spans the nuclear envelope of a cell and provides a channel through which RNA and proteins move between the nucleus and the cytoplasm and vice versa. NUP and NPC disruptions have a great impact on the pathophysiology of neurodegenerative diseases (NDDs). Although the downregulation of Nup358 leads to a reduction in the scaffold protein ankyrin-G at the axon initial segment (AIS) of mature neurons, the function of Nup358 in the cytoplasm of neurons remains elusive. To investigate whether Nup358 plays any role in neuronal activity, we downregulated Nup358 in non-pathological mouse cortical neurons and measured their active and passive bioelectrical properties. We identified that Nup358 downregulation is able to produce significant modifications of cell-membrane excitability via voltage-gated sodium channel kinetics. Our findings suggest that Nup358 contributes to neuronal excitability through a functional stabilization of the electrical properties of the neuronal membrane. Hypotheses will be discussed regarding the alteration of this active regulation as putatively occurring in the pathophysiology of NDDs." @default.
- W4386074294 created "2023-08-23" @default.
- W4386074294 creator A5010835896 @default.
- W4386074294 creator A5021115543 @default.
- W4386074294 creator A5033333557 @default.
- W4386074294 creator A5044501677 @default.
- W4386074294 creator A5061504579 @default.
- W4386074294 creator A5078249480 @default.
- W4386074294 creator A5089724316 @default.
- W4386074294 date "2023-08-22" @default.
- W4386074294 modified "2023-10-17" @default.
- W4386074294 title "Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical Neurons" @default.
- W4386074294 cites W1982401614 @default.
- W4386074294 cites W1989092549 @default.
- W4386074294 cites W2033318695 @default.
- W4386074294 cites W2037289852 @default.
- W4386074294 cites W2038097452 @default.
- W4386074294 cites W2050642734 @default.
- W4386074294 cites W2072274637 @default.
- W4386074294 cites W2103851941 @default.
- W4386074294 cites W2111166374 @default.
- W4386074294 cites W2150605329 @default.
- W4386074294 cites W2171051669 @default.
- W4386074294 cites W2171485643 @default.
- W4386074294 cites W2564335181 @default.
- W4386074294 cites W2574622463 @default.
- W4386074294 cites W2612465035 @default.
- W4386074294 cites W2734059936 @default.
- W4386074294 cites W2852401257 @default.
- W4386074294 cites W2902996730 @default.
- W4386074294 cites W2905808113 @default.
- W4386074294 cites W2906787593 @default.
- W4386074294 cites W2911957158 @default.
- W4386074294 cites W2948843491 @default.
- W4386074294 cites W2954520844 @default.
- W4386074294 cites W2957971038 @default.
- W4386074294 cites W2969825427 @default.
- W4386074294 cites W2996955222 @default.
- W4386074294 cites W3011009459 @default.
- W4386074294 cites W3081987483 @default.
- W4386074294 cites W3126347893 @default.
- W4386074294 cites W3162690013 @default.
- W4386074294 cites W3195338568 @default.
- W4386074294 cites W3213725766 @default.
- W4386074294 cites W4210493568 @default.
- W4386074294 cites W4220771117 @default.
- W4386074294 cites W4225109825 @default.
- W4386074294 cites W4295927912 @default.
- W4386074294 cites W4312076906 @default.
- W4386074294 cites W4380050605 @default.
- W4386074294 doi "https://doi.org/10.3390/life13091791" @default.
- W4386074294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37763196" @default.
- W4386074294 hasPublicationYear "2023" @default.
- W4386074294 type Work @default.
- W4386074294 citedByCount "0" @default.
- W4386074294 crossrefType "journal-article" @default.
- W4386074294 hasAuthorship W4386074294A5010835896 @default.
- W4386074294 hasAuthorship W4386074294A5021115543 @default.
- W4386074294 hasAuthorship W4386074294A5033333557 @default.
- W4386074294 hasAuthorship W4386074294A5044501677 @default.
- W4386074294 hasAuthorship W4386074294A5061504579 @default.
- W4386074294 hasAuthorship W4386074294A5078249480 @default.
- W4386074294 hasAuthorship W4386074294A5089724316 @default.
- W4386074294 hasBestOaLocation W43860742941 @default.
- W4386074294 hasConcept C104317684 @default.
- W4386074294 hasConcept C126725582 @default.
- W4386074294 hasConcept C127561419 @default.
- W4386074294 hasConcept C169760540 @default.
- W4386074294 hasConcept C178790620 @default.
- W4386074294 hasConcept C185592680 @default.
- W4386074294 hasConcept C190062978 @default.
- W4386074294 hasConcept C2780114586 @default.
- W4386074294 hasConcept C50952357 @default.
- W4386074294 hasConcept C537181965 @default.
- W4386074294 hasConcept C54355233 @default.
- W4386074294 hasConcept C59157529 @default.
- W4386074294 hasConcept C68556195 @default.
- W4386074294 hasConcept C86803240 @default.
- W4386074294 hasConcept C95444343 @default.
- W4386074294 hasConceptScore W4386074294C104317684 @default.
- W4386074294 hasConceptScore W4386074294C126725582 @default.
- W4386074294 hasConceptScore W4386074294C127561419 @default.
- W4386074294 hasConceptScore W4386074294C169760540 @default.
- W4386074294 hasConceptScore W4386074294C178790620 @default.
- W4386074294 hasConceptScore W4386074294C185592680 @default.
- W4386074294 hasConceptScore W4386074294C190062978 @default.
- W4386074294 hasConceptScore W4386074294C2780114586 @default.
- W4386074294 hasConceptScore W4386074294C50952357 @default.
- W4386074294 hasConceptScore W4386074294C537181965 @default.
- W4386074294 hasConceptScore W4386074294C54355233 @default.
- W4386074294 hasConceptScore W4386074294C59157529 @default.
- W4386074294 hasConceptScore W4386074294C68556195 @default.
- W4386074294 hasConceptScore W4386074294C86803240 @default.
- W4386074294 hasConceptScore W4386074294C95444343 @default.
- W4386074294 hasIssue "9" @default.
- W4386074294 hasLocation W43860742941 @default.
- W4386074294 hasLocation W43860742942 @default.
- W4386074294 hasOpenAccess W4386074294 @default.