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- W4386074657 abstract "Background: Polygenic Risk Scores (PRS) are calculated as the weighted number of genetic risk alleles in an individual's genome, with the risk alleles and their weights typically derived from the results of genome-wide association studies (GWAS). Pathway-specific PRS are genetic scores based on SNPs corresponding to genes involved in major disease pathways and can be used for stratification of patient cohorts for treatment trials targeting specific disease mechanisms. The aim of this study is to assess and compare the predictive value of pathway PRS , including mitochondrial (Mito) and autophagy-lysosomal pathways (ALP), to PRS generated from all GWAS hit SNPs (Hit model) in predicting Parkinson’s disease (PD) status as well as relevant clinical outcomes." @default.
- W4386074657 created "2023-08-23" @default.
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- W4386074657 date "2023-08-01" @default.
- W4386074657 modified "2023-09-25" @default.
- W4386074657 title "Autophagy-lysosomal and mitochondrial polygenic risk scores in Parkinson's disease" @default.
- W4386074657 doi "https://doi.org/10.1016/j.parkreldis.2023.105592" @default.
- W4386074657 hasPublicationYear "2023" @default.
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