FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386083786> ?p ?o ?g. }

• W4386083786 abstract "Background Observational associations between type 2 diabetes (T2D) and atrial fibrillation (AF) have been established, but causality remains undetermined. We performed Mendelian randomization (MR) to study causal effects of genetically predicted T2D on AF risk, independent of cardiometabolic risk factors. Methods and Results Instrumental variables included 182 uncorrelated single nucleotide polymorphisms associated with T2D at genome-wide significance (P <5×10-8). Genetic association estimates for cardiometabolic exposures were obtained from genome-wide association studies including 188 577 individuals for low-density lipoprotein-C, 694 649 individuals for body mass index, and 757 601 for systolic blood pressure. Two-sample, inverse-variance weighted MR formed the primary analyses. The MR-TRYX approach was used to dissect potential pleiotropic pathways, with multivariable MR performed to investigate cardiometabolic mediation. Genetically predicted T2D associated with increased AF liability in univariable MR (odds ratio [OR], 1.08 [95% CI, 1.02-1.13], P=0.003). Sensitivity analyses indicated potential pleiotropy, with radial MR identifying 4 outlier single nucleotide polymorphisms that were likely contributors. Phenomic scanning on MR-base and subsequent least absolute shrinkage and selection operator regression allowed prioritization of 7 candidate traits. The outlier-adjusted effect estimate remained consistent with the original inverse-variance weighted estimate (OR, 1.07 [95% CI, 1.02-1.12], P=0.008). On multivariable MR, T2D remained associated with increased AF liability after adjustment for low-density lipoprotein-C and body mass index. Following adjustment for systolic blood pressure, the relationship between T2D and AF became nonsignificant (OR, 1.04 [95% CI, 0.95-1.13], P=0.40). Conclusions These data provide novel genetic evidence that while T2D likely causally associates with AF, mediation via systolic blood pressure exists. Endeavoring to lower systolic blood pressure alongside achieving normoglycemia may provide particular benefit on AF risk in patients with T2D." @default.
• W4386083786 created "2023-08-24" @default.
• W4386083786 creator A5010738178 @default.
• W4386083786 creator A5059783996 @default.
• W4386083786 creator A5075213080 @default.
• W4386083786 date "2023-09-05" @default.
• W4386083786 modified "2023-10-16" @default.
• W4386083786 title "Type 2 Diabetes and Atrial Fibrillation: Evaluating Causal and Pleiotropic Pathways Using Mendelian Randomization" @default.
• W4386083786 cites W1972229070 @default.
• W4386083786 cites W1982243909 @default.
• W4386083786 cites W2072677007 @default.
• W4386083786 cites W2126237420 @default.
• W4386083786 cites W2153118028 @default.
• W4386083786 cites W2166966803 @default.
• W4386083786 cites W2512483039 @default.
• W4386083786 cites W2528389922 @default.
• W4386083786 cites W2588391596 @default.
• W4386083786 cites W2617316722 @default.
• W4386083786 cites W2735339162 @default.
• W4386083786 cites W2755166087 @default.
• W4386083786 cites W2761141539 @default.
• W4386083786 cites W2883415719 @default.
• W4386083786 cites W2894662039 @default.
• W4386083786 cites W2915472415 @default.
• W4386083786 cites W2952686929 @default.
• W4386083786 cites W2966592928 @default.
• W4386083786 cites W2998251647 @default.
• W4386083786 cites W3007536163 @default.
• W4386083786 cites W3021859981 @default.
• W4386083786 cites W3036816724 @default.
• W4386083786 cites W3082188176 @default.
• W4386083786 cites W3093789410 @default.
• W4386083786 cites W3119516105 @default.
• W4386083786 cites W3199384184 @default.
• W4386083786 cites W4220966186 @default.
• W4386083786 cites W4224288909 @default.
• W4386083786 cites W4236833867 @default.
• W4386083786 cites W4280552086 @default.
• W4386083786 doi "https://doi.org/10.1161/jaha.123.030298" @default.
• W4386083786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37609985" @default.
• W4386083786 hasPublicationYear "2023" @default.
• W4386083786 type Work @default.
• W4386083786 citedByCount "0" @default.
• W4386083786 crossrefType "journal-article" @default.
• W4386083786 hasAuthorship W4386083786A5010738178 @default.
• W4386083786 hasAuthorship W4386083786A5059783996 @default.
• W4386083786 hasAuthorship W4386083786A5075213080 @default.
• W4386083786 hasConcept C104317684 @default.
• W4386083786 hasConcept C106208931 @default.
• W4386083786 hasConcept C126322002 @default.
• W4386083786 hasConcept C134018914 @default.
• W4386083786 hasConcept C135763542 @default.
• W4386083786 hasConcept C153209595 @default.
• W4386083786 hasConcept C164705383 @default.
• W4386083786 hasConcept C2777180221 @default.
• W4386083786 hasConcept C2779901538 @default.
• W4386083786 hasConcept C2780221984 @default.
• W4386083786 hasConcept C2993967602 @default.
• W4386083786 hasConcept C54355233 @default.
• W4386083786 hasConcept C555293320 @default.
• W4386083786 hasConcept C71924100 @default.
• W4386083786 hasConcept C86803240 @default.
• W4386083786 hasConceptScore W4386083786C104317684 @default.
• W4386083786 hasConceptScore W4386083786C106208931 @default.
• W4386083786 hasConceptScore W4386083786C126322002 @default.
• W4386083786 hasConceptScore W4386083786C134018914 @default.
• W4386083786 hasConceptScore W4386083786C135763542 @default.
• W4386083786 hasConceptScore W4386083786C153209595 @default.
• W4386083786 hasConceptScore W4386083786C164705383 @default.
• W4386083786 hasConceptScore W4386083786C2777180221 @default.
• W4386083786 hasConceptScore W4386083786C2779901538 @default.
• W4386083786 hasConceptScore W4386083786C2780221984 @default.
• W4386083786 hasConceptScore W4386083786C2993967602 @default.
• W4386083786 hasConceptScore W4386083786C54355233 @default.
• W4386083786 hasConceptScore W4386083786C555293320 @default.
• W4386083786 hasConceptScore W4386083786C71924100 @default.
• W4386083786 hasConceptScore W4386083786C86803240 @default.
• W4386083786 hasIssue "17" @default.
• W4386083786 hasLocation W43860837861 @default.
• W4386083786 hasLocation W43860837862 @default.
• W4386083786 hasOpenAccess W4386083786 @default.
• W4386083786 hasPrimaryLocation W43860837861 @default.
• W4386083786 hasRelatedWork W2148532613 @default.
• W4386083786 hasRelatedWork W2946612292 @default.
• W4386083786 hasRelatedWork W2952883732 @default.
• W4386083786 hasRelatedWork W3128910052 @default.
• W4386083786 hasRelatedWork W4205420791 @default.
• W4386083786 hasRelatedWork W4281777829 @default.
• W4386083786 hasRelatedWork W4313402980 @default.
• W4386083786 hasRelatedWork W4319459798 @default.
• W4386083786 hasRelatedWork W4320065076 @default.
• W4386083786 hasRelatedWork W618380765 @default.
• W4386083786 hasVolume "12" @default.
• W4386083786 isParatext "false" @default.
• W4386083786 isRetracted "false" @default.
• W4386083786 workType "article" @default.