FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386083886> ?p ?o ?g. }

• W4386083886 abstract "Osteogenic sarcoma (OS), one of the mesenchymal tumors with a high degree of malignancy, mainly occurs in the metaphysis of the long bones and around the knee joints in children and adolescents. The poor diagnosis in patients with OS can be attributed to the lack of early clinical symptoms, although the growth of tumor mass gradually results in severe pain and systemic symptoms. The mechanisms underlying the pathogenesis of OS are not fully understood. Thus, identifying early diagnostic biomarkers and novel targets involved in the progression of OS is of critical significance in the management of OS. CircRNA is a class of non-coding RNAs characterized by the close-loop structure and increased stability, which are implicated in the regulation of cell proliferation, differentiation, migration, and apoptosis. Moreover, circRNAs also play significant roles in aging and chronic disorders, such as cancer and cardiovascular diseases. Accordingly, we reported the upregulation of circRNA-CIRH1A in OS tissues and cell lines. Silencing circRNA-CIRH1A in OS cell lines (U2OS, HOS, Saos-2, and MG-63) could inhibit the cell proliferation, invasion, migration, and apoptosis, which was also validated in xenograft tumorigenesis mouse model. We further demonstrated that circRNA-CIRH1A sponged miR-1276, which subsequently disrupted the effect of miR-1276 on PI3K/AKT and JAK2/STAT3 signaling pathways. Together, our study revealed the oncogenic role of circRNA-CIRH1A in OS, and identified miR-1276/ PI3K-AKT and JAK2-STAT3 signaling axis as the key downstream mediators of circRNA-CIRH1A." @default.
• W4386083886 created "2023-08-24" @default.
• W4386083886 creator A5005403891 @default.
• W4386083886 creator A5009557503 @default.
• W4386083886 creator A5017491516 @default.
• W4386083886 creator A5025261523 @default.
• W4386083886 creator A5033647915 @default.
• W4386083886 creator A5036822385 @default.
• W4386083886 creator A5044741151 @default.
• W4386083886 creator A5070501452 @default.
• W4386083886 creator A5074140059 @default.
• W4386083886 date "2023-08-23" @default.
• W4386083886 modified "2023-09-24" @default.
• W4386083886 title "CircRNA-CIRH1A Promotes the Development of Osteosarcoma by Regulating PI3K/AKT and JAK2/STAT3 Signaling Pathways" @default.
• W4386083886 cites W133663130 @default.
• W4386083886 cites W1568027430 @default.
• W4386083886 cites W1974250949 @default.
• W4386083886 cites W2032358116 @default.
• W4386083886 cites W2086103499 @default.
• W4386083886 cites W2087093933 @default.
• W4386083886 cites W2130424021 @default.
• W4386083886 cites W2201823324 @default.
• W4386083886 cites W2240434829 @default.
• W4386083886 cites W2328671688 @default.
• W4386083886 cites W2596045267 @default.
• W4386083886 cites W2791369147 @default.
• W4386083886 cites W2802436983 @default.
• W4386083886 cites W2886288610 @default.
• W4386083886 cites W2920638667 @default.
• W4386083886 cites W2920730547 @default.
• W4386083886 cites W2942868969 @default.
• W4386083886 cites W2943061777 @default.
• W4386083886 cites W2949868877 @default.
• W4386083886 cites W2969214885 @default.
• W4386083886 cites W2979562838 @default.
• W4386083886 cites W2980508769 @default.
• W4386083886 cites W2991427346 @default.
• W4386083886 cites W3002170034 @default.
• W4386083886 cites W3014459671 @default.
• W4386083886 cites W3023058280 @default.
• W4386083886 cites W3029883196 @default.
• W4386083886 cites W3033672408 @default.
• W4386083886 cites W3082112770 @default.
• W4386083886 cites W3095906665 @default.
• W4386083886 cites W3125778082 @default.
• W4386083886 cites W3155484860 @default.
• W4386083886 cites W4232354013 @default.
• W4386083886 cites W4235565063 @default.
• W4386083886 cites W4244782966 @default.
• W4386083886 cites W4248865982 @default.
• W4386083886 doi "https://doi.org/10.1007/s12033-023-00812-0" @default.
• W4386083886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37608076" @default.
• W4386083886 hasPublicationYear "2023" @default.
• W4386083886 type Work @default.
• W4386083886 citedByCount "0" @default.
• W4386083886 crossrefType "journal-article" @default.
• W4386083886 hasAuthorship W4386083886A5005403891 @default.
• W4386083886 hasAuthorship W4386083886A5009557503 @default.
• W4386083886 hasAuthorship W4386083886A5017491516 @default.
• W4386083886 hasAuthorship W4386083886A5025261523 @default.
• W4386083886 hasAuthorship W4386083886A5033647915 @default.
• W4386083886 hasAuthorship W4386083886A5036822385 @default.
• W4386083886 hasAuthorship W4386083886A5044741151 @default.
• W4386083886 hasAuthorship W4386083886A5070501452 @default.
• W4386083886 hasAuthorship W4386083886A5074140059 @default.
• W4386083886 hasBestOaLocation W43860838861 @default.
• W4386083886 hasConcept C104317684 @default.
• W4386083886 hasConcept C119056186 @default.
• W4386083886 hasConcept C121608353 @default.
• W4386083886 hasConcept C126322002 @default.
• W4386083886 hasConcept C127561419 @default.
• W4386083886 hasConcept C137738243 @default.
• W4386083886 hasConcept C142724271 @default.
• W4386083886 hasConcept C1491633281 @default.
• W4386083886 hasConcept C190283241 @default.
• W4386083886 hasConcept C2777760704 @default.
• W4386083886 hasConcept C2778923194 @default.
• W4386083886 hasConcept C502942594 @default.
• W4386083886 hasConcept C54355233 @default.
• W4386083886 hasConcept C555283112 @default.
• W4386083886 hasConcept C62112901 @default.
• W4386083886 hasConcept C62478195 @default.
• W4386083886 hasConcept C71924100 @default.
• W4386083886 hasConcept C75217442 @default.
• W4386083886 hasConcept C86554907 @default.
• W4386083886 hasConcept C86803240 @default.
• W4386083886 hasConcept C95444343 @default.
• W4386083886 hasConceptScore W4386083886C104317684 @default.
• W4386083886 hasConceptScore W4386083886C119056186 @default.
• W4386083886 hasConceptScore W4386083886C121608353 @default.
• W4386083886 hasConceptScore W4386083886C126322002 @default.
• W4386083886 hasConceptScore W4386083886C127561419 @default.
• W4386083886 hasConceptScore W4386083886C137738243 @default.
• W4386083886 hasConceptScore W4386083886C142724271 @default.
• W4386083886 hasConceptScore W4386083886C1491633281 @default.
• W4386083886 hasConceptScore W4386083886C190283241 @default.
• W4386083886 hasConceptScore W4386083886C2777760704 @default.
• W4386083886 hasConceptScore W4386083886C2778923194 @default.
• W4386083886 hasConceptScore W4386083886C502942594 @default.
• W4386083886 hasConceptScore W4386083886C54355233 @default.

• next