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- W4386083932 abstract "Polygenic risk scores (PRS) summarize an individual's germline genetic risk, but it is unclear whether PRS offer independent information for pancreatic cancer (PC) risk prediction beyond routine clinical data.We searched 8 databases from database inception to 3/10/2023 to identify studies evaluating the independent performance of PC-specific PRS for PC beyond clinical risk factors.Twenty-one studies examined associations between a PC-specific PRS and PC. Seven studies evaluated risk factors beyond age and sex. Three studies evaluated the change in discrimination associated with the addition of PRS to routine risk factors and reported improvements [(AUCs: 0.715 to 0.745; AUC 0.791 to 0.830; AUC from 0.694 to 0.711]. Limitations to clinical applicability included using source populations younger/healthier than those at risk for PC (n=10), exclusively of European ancestry (n=13), or controls without relevant exposures (n=1).While most studies of PC-specific PRS did not evaluate the independent discrimination of PRS for PC beyond routine risk factors, three that did showed improvements in discrimination.For PC PRS to be clinically useful, they must demonstrate substantial improvements in discrimination beyond established risk factors, apply to diverse ancestral populations representative of those at risk for PC, and use appropriate controls." @default.
- W4386083932 created "2023-08-24" @default.
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- W4386083932 date "2023-09-13" @default.
- W4386083932 modified "2023-10-18" @default.
- W4386083932 title "Do polygenic risk scores add to clinical data in predicting pancreatic cancer? a scoping review" @default.
- W4386083932 doi "https://doi.org/10.1158/1055-9965.epi-23-0468" @default.
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- W4386083932 hasPublicationYear "2023" @default.
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