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- W4386084203 abstract "Abstract Knowledge about early immunity to SARS‐CoV‐2 variants of concern mainly comes from the analysis of human blood. Such data provide limited information about host responses at the site of infection and largely miss the initial events. To gain insights into compartmentalization and the early dynamics of host responses to different SARS‐CoV‐2 variants, we utilized human angiotensin converting enzyme 2 (hACE2) transgenic mice and tracked immune changes during the first days after infection by RNAseq, multiplex assays, and flow cytometry. Viral challenge infection led to divergent viral loads in the lungs, distinct inflammatory patterns, and innate immune cell accumulation in response to ancestral SARS‐CoV‐2, Beta (B.1.351) and Delta (B.1.617.2) variant of concern (VOC). Compared to other SARS‐CoV‐2 variants, infection with Beta (B.1.351) VOC spread promptly to the lungs, leading to increased inflammatory responses. SARS‐CoV‐2‐specific antibodies and T cells developed within the first 7 days postinfection and were required to reduce viral spread and replication. Our studies show that VOCs differentially trigger transcriptional profiles and inflammation. This information contributes to the basic understanding of immune responses immediately postexposure to SARS‐CoV‐2 and is relevant for developing pan‐VOC interventions including prophylactic vaccines." @default.
- W4386084203 created "2023-08-24" @default.
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- W4386084203 date "2023-09-07" @default.
- W4386084203 modified "2023-10-15" @default.
- W4386084203 title "SARS‐CoV‐2 variants of concern elicit divergent early immune responses in hACE2 transgenic mice" @default.
- W4386084203 cites W1989069389 @default.
- W4386084203 cites W2037123168 @default.
- W4386084203 cites W2043343078 @default.
- W4386084203 cites W2179438025 @default.
- W4386084203 cites W2197124664 @default.
- W4386084203 cites W2943109925 @default.
- W4386084203 cites W2948824749 @default.
- W4386084203 cites W2950221693 @default.
- W4386084203 cites W2951931980 @default.
- W4386084203 cites W3009859788 @default.
- W4386084203 cites W3016489853 @default.
- W4386084203 cites W3017125154 @default.
- W4386084203 cites W3020655115 @default.
- W4386084203 cites W3022435472 @default.
- W4386084203 cites W3024643080 @default.
- W4386084203 cites W3025320502 @default.
- W4386084203 cites W3031410383 @default.
- W4386084203 cites W3036602039 @default.
- W4386084203 cites W3037718428 @default.
- W4386084203 cites W3041494167 @default.
- W4386084203 cites W3044799813 @default.
- W4386084203 cites W3047876262 @default.
- W4386084203 cites W3048903202 @default.
- W4386084203 cites W3049048202 @default.
- W4386084203 cites W3049325061 @default.
- W4386084203 cites W3080378920 @default.
- W4386084203 cites W3084879098 @default.
- W4386084203 cites W3085958090 @default.
- W4386084203 cites W3086298873 @default.
- W4386084203 cites W3086407960 @default.
- W4386084203 cites W3099347064 @default.
- W4386084203 cites W3102451335 @default.
- W4386084203 cites W3105908160 @default.
- W4386084203 cites W3109926113 @default.
- W4386084203 cites W3110730557 @default.
- W4386084203 cites W3113228067 @default.
- W4386084203 cites W3116021319 @default.
- W4386084203 cites W3116593921 @default.
- W4386084203 cites W3122197559 @default.
- W4386084203 cites W3123064250 @default.
- W4386084203 cites W3123405441 @default.
- W4386084203 cites W3128962620 @default.
- W4386084203 cites W3133989519 @default.
- W4386084203 cites W3134937376 @default.
- W4386084203 cites W3136193945 @default.
- W4386084203 cites W3139367841 @default.
- W4386084203 cites W3158953228 @default.
- W4386084203 cites W3159224617 @default.
- W4386084203 cites W3159762970 @default.
- W4386084203 cites W3160342471 @default.
- W4386084203 cites W3161377421 @default.
- W4386084203 cites W3173609584 @default.
- W4386084203 cites W3175809015 @default.
- W4386084203 cites W3176127947 @default.
- W4386084203 cites W3180285023 @default.
- W4386084203 cites W3183793113 @default.
- W4386084203 cites W3191798542 @default.
- W4386084203 cites W3192313478 @default.
- W4386084203 cites W3194891808 @default.
- W4386084203 cites W3197127917 @default.
- W4386084203 cites W3199731605 @default.
- W4386084203 cites W3201832707 @default.
- W4386084203 cites W3213524488 @default.
- W4386084203 cites W3214110703 @default.
- W4386084203 cites W3216618416 @default.
- W4386084203 cites W3216680393 @default.
- W4386084203 cites W4200216147 @default.
- W4386084203 cites W4200344940 @default.
- W4386084203 cites W4210728310 @default.
- W4386084203 cites W4221008923 @default.
- W4386084203 cites W4223902721 @default.
- W4386084203 cites W4223926791 @default.
- W4386084203 cites W4226053901 @default.
- W4386084203 cites W4226055319 @default.
- W4386084203 cites W4281926820 @default.
- W4386084203 cites W4283515582 @default.
- W4386084203 cites W4286587254 @default.
- W4386084203 cites W4288040280 @default.
- W4386084203 cites W4293469392 @default.
- W4386084203 cites W4295759401 @default.
- W4386084203 cites W4295786903 @default.
- W4386084203 cites W4320483863 @default.