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- W4386084359 abstract "Aryl amines are of constant interest in organic synthesis owing to their ubiquity in natural products, pharmaceuticals, and organic materials. However, C-H amination or pre-functionalization frequently results in uncontrollable site selectivity, over activation and the generation of inseparable mixtures of regio-isomers. Here we present a novel metal free Dötz-type aminobenzannulation reaction that circumvents the selectivity issues inherent in aromatic chemistry, as well as the use of stoichiometric unstable organolithium reagents and toxic chromium complexes. The concept of utilizing readily available isocyanides and Morita-Baylis-Hillman (MBH) carbonates to achieve 1,1-dipoles cross-coupling to construct ketenimine is the key to success, which has been experimentally and computationally verified. The tandem 6π-electrocyclization/aromatization process offers a versatile method for synthesizing functionalized anilines, fused aryl amines and fused heteroaryl amines." @default.
- W4386084359 created "2023-08-24" @default.
- W4386084359 creator A5032545702 @default.
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- W4386084359 date "2023-09-01" @default.
- W4386084359 modified "2023-10-14" @default.
- W4386084359 title "Metal Free Dötz‐Type Aminobenzannulation Reaction via 1,1‐Dipoles Cross‐Coupling" @default.
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- W4386084359 doi "https://doi.org/10.1002/anie.202310133" @default.
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