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• W4386086248 abstract "Fungal invasion of the oral epithelium is central to the pathogenesis of oropharyngeal candidiasis (OPC). Candida albicans invades the oral epithelium by receptor-induced endocytosis but this process is incompletely understood. We found that C . albicans infection of oral epithelial cells induces c-Met to form a multi-protein complex with E-cadherin and the epidermal growth factor receptor (EGFR). E-cadherin is necessary for C . albicans to activate both c-Met and EGFR and to induce the endocytosis of C . albicans . Proteomics analysis revealed that c-Met interacts with C . albicans Hyr1, Als3 and Ssa1. Both Hyr1 and Als3 are required for C . albicans to stimulate c-Met and EGFR in oral epithelial cells in vitro and for full virulence during OPC in mice. Treating mice with small molecule inhibitors of c-Met and EGFR ameliorates OPC, demonstrating the potential therapeutic efficacy of blocking these host receptors for C . albicans ." @default.
• W4386086248 created "2023-08-24" @default.
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• W4386086248 date "2023-08-23" @default.
• W4386086248 modified "2023-09-24" @default.
• W4386086248 title "Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection" @default.
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• W4386086248 doi "https://doi.org/10.1371/journal.ppat.1011579" @default.
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