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- W4386086982 abstract "Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: Cytogenetic is of prognostic interest and an indispensable therapeutic stratification tool in the management of acute myeloid leukemia. Aims: Describe the cytogenetic profile of acute myeloblastic leukemia’s (AML) treated in the Clinical Hematology Department of the Military Hospital (HMIMV) of Rabat. Methods: We analyzed the cytogenetic profiles of patients older than 16 years followed for the acute myeloblastic leukemia (excluding APL) in the Clinical Hematology Department of the HMIMV over an 18-year period from May 2006 to February 2023. Results: 103 records were reviewed. The karyotype was systematically performed in all patients at diagnosis, it was in failure in 12 patients (11.6%), normal in 37 patients (36%) and a clonal abnormality was detected in 54 patients (52.4%). Cytogenetic abnormalities were divided into 3 groups according to ELN 2022 classification (favorable, intermediate and unfavorable); the intermediate risk group was predominant (56.3%) divided into normal karyotype in 37 patients (36%), Trisomy 8 in six patients(5.8%), t(9;11), t(8; 22), monosomy 20, monosomy 15, del 11q23, del y, Add 16, add 21, trisomy 11q, del 6q in one patient each and del17q and del 20q in two patients respectively; followed by the group with unfavorable cytogenetic risk in 21 patients (20%) divided into complex karyotype in 13 patients (12.6%), deletion of chromosome 7q in 5 patients (5%), t (9-22) in 2 patients and deletion 5q in one patient. Twelve patients (11%) had favorable risk cytogenetics consisting of a t(8-21) in 7 patients (6.7%) and an inversion 16 in 5 patients respectively. Intermediate risk cytogenetics was predominant in our patients. Summary/Conclusion: Despite the small number of patients in this mono-centric study, we note the frequency of intermediate cytogenetic risk obliging the clinician to perform molecular biology to refine the prognosis. This result is comparable to those found in the literature. Keywords: AML" @default.
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- W4386086982 date "2023-08-01" @default.
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- W4386086982 title "PB1839: CYTOGENETIC PROFILE OF ACUTE MYELOBLASTIC LEUKEMIA TREATED AT THE MOHAMMED V MILITARY HOSPITAL IN RABAT (MOROCCO)." @default.
- W4386086982 doi "https://doi.org/10.1097/01.hs9.0000974200.65357.51" @default.
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