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• W4386087221 abstract "The intramammary infusion at the end of lactation of a bismuth subnitrate internal teat sealant (ITS), with no antibiotic component has been shown to be an effective means of reducing new intra-mammary infections (IMI) over the dry period. There has, however, been very few comparative studies between different brands of ITS under grazed pasture conditions. The objectives of this study were, therefore, to determine if a new bismuth subnitrate internal teal sealant (Shutout®, MSD Animal Health, Wellington, New Zealand) was non-inferior to Teatseal (Zoetis, Auckland, New Zealand) regarding endpoints such as a) detection of the ITS product after calving, b) clinical mastitis during the dry period and early lactation, and c) subclinical mastitis at 30-60 d-in-milk. A total of 1105 mixed age cattle were enrolled across 2 farms comparing 2 ITS products for detection of the ITS at calving and prevention of clinical and subclinical mastitis. Both ITS contained 65% (2.6 g) bismuth salts emulsified in ≤ 1.4 g of mineral oil (Shutout® as Investigational Product; IVP and Teatseal as control product; CP). At dry off, treatment was allocated to every second cow. All cows met industry best practice criteria for using ITS treatment without antibiotics. Outcomes included detection of ITS at first stripping of the udder by the farmer, clinical mastitis (CM) from dry-off to 30 d following calving and subclinical mastitis (SCM) at 30-60 d following calving. For ITS detection, a generalized mixed linear regression model was used to model the data, with clustering of quarters within cow accounted for by including cow as a random intercept. CM was analyzed at the cow-level using a Fisher's exact test, and SCC was modeled using a negative binomial distribution. The IVP was non-inferior to the CP for ITS detection following calving. There were 1344/1800 (71.5%) of quarters with ITS detection in the IVP in comparison to 1076/1604 (67.1%) of quarters in the CP treated group. The quarter-level CM incidence risk was low (45 cases out 4324 quarters; 1.04%). The overall cow-level CM risk was 4.1% (44/1081), with 20/540 (3.7%) cases in animals in the IVP group and 24/541 (4.4%) cases in animals in the CP group. The IVP was non-inferior to the CP for cow-level mastitis incidence. The median SCC for all animals was 23,000 cells/mL, with a mean of 92,000 cells/mL. The back-transformed estimated marginal mean estimated SCC was 84,800 (95% CI 75,200 - 95,600) cells/mL for animals in the IVP group, and 98,800 (95% CI 87,600 - 111,300) cells/mL for animals in the CP group. The IVP was, therefore, non-inferior for all outcomes measured." @default.
• W4386087221 created "2023-08-24" @default.
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• W4386087221 date "2023-08-01" @default.
• W4386087221 modified "2023-10-05" @default.
• W4386087221 title "Randomized, non-inferiority trial evaluating the efficacy of a novel teat sealant in pasture grazed dairy cows" @default.
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• W4386087221 doi "https://doi.org/10.3168/jds.2022-23134" @default.
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