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- W4386089647 abstract "<ns4:p><ns4:bold>Background: </ns4:bold>Previous studies have pointed out the disproportionate action of clopidogrel in inhibiting platelet aggregation due to smoking more than ten cigarettes per a day. This study was designed to examine whether smoking enhances clopidogrel responsiveness in patients who are clinically diagnosed with coronary artery disease (CAD), following percutaneous coronary intervention (PCI).</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>A total of<ns4:bold> </ns4:bold>324 IHD participants were enrolled in a case-control study. Platelet function test was performed to all participants two hours before PCI procedure to measure clopidogrel response. Participants were then categorized into a non-responder group (case group n = 111) and responder group (control group n = 213). Each group was subdivided into a smoker group and a non-smoker group. All participants received clopidogrel loading dose equivalent to 600 mg and scheduled for elective PCI. Participants’ age, gender, family history of chronic illnesses was recorded in this study. </ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>Smoking participants displayed a significant higher level of hemoglobin as compared to the non-smoking participants among the responder and the non-responder study groups (14.6±0.55 vs. 13.12±0.38, <ns4:italic>P</ns4:italic> < 0.029; 14.3±0.31 <ns4:italic>versus</ns4:italic> 12.96±0.39, <ns4:italic>P</ns4:italic> < 0.033) but lower AUC level (17±9 vs. 45±6, <ns4:italic>P</ns4:italic> < 0.005; 62±3 vs. 95±7, <ns4:italic>P</ns4:italic> < 0.008).</ns4:p><ns4:p> Additionally, smoking intensity enhanced clopidogrel responsiveness by odd’s ratio 0.4213 at 95% C.I. (0.259 - 0.684), <ns4:italic>P</ns4:italic> < 0.0002.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Conclusions: </ns4:bold>Current smokers had a good response to clopidogrel therapy which exerted a beneficial effect when undergoing PCI as compared to non-smokers. The marked difference in AUC between smokers and non-smokers could be related to the variance in hemoglobin level. The smokers’ paradox needs further justification to confirm this concept.</ns4:p>" @default.
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- W4386089647 date "2023-08-23" @default.
- W4386089647 modified "2023-09-27" @default.
- W4386089647 title "The impact of smoking status on clopidogrel responsiveness in patients with coronary artery disease who undergo percutaneous coronary intervention" @default.
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- W4386089647 doi "https://doi.org/10.12688/f1000research.131820.2" @default.
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