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• W4386090468 abstract "Sulfation is a widespread modification of biomolecules that has been incompletely explored to date. Through cross-phenotype meta-analysis of bone mineral density in up to 426,824 genotyped human participants along with phenotypic characterization of multiple mutant mouse lines, we identified a causative role for sulfate transporter solute carrier family 26 member A2 ( SLC26A2 ) deficiency in osteoporosis. Ablation of SLC26A2 in osteoblasts caused severe bone loss and accumulation of immature bone cells and elicited peculiar pericellular matrix (PCM) production characterized by undersulfation coupled with decreased stiffness. These altered chemophysical properties of the PCM disrupted the formation of focal adhesions in osteoblasts. Bulk RNA sequencing and functional assays revealed that the mechanoreciprocal inhibition of focal adhesion kinase (FAK) and Yes1-associated transcriptional regulator (YAP)/WW domain containing transcription regulator 1 (TAZ) signaling impinged osteoblast maturation upon SLC26A2 deficiency. Moreover, pharmacological abrogation of the Hippo kinases and forced wheel-running ameliorated SLC26A2 -deficient osteoporosis by promoting YAP/TAZ activity. Analysis of mouse single-cell RNA sequencing data suggested coordination among sulfate metabolism, focal adhesion, and YAP/TAZ activity during osteoblast-to-osteocyte transition. In addition to the SLC26A2 -deficient setting, altered FAK and YAP/TAZ signaling was also observed in bone cells of ovariectomized mice and patients with osteoporosis, and pharmacological enforcing of YAP/TAZ activity ameliorated bone loss in ovariectomized mice. Collectively, these data unveil a role for sulfation in the developmental mechanoreciprocity between matrix and osteoblasts, which could be leveraged to prevent bone loss." @default.
• W4386090468 created "2023-08-24" @default.
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• W4386090468 date "2023-08-23" @default.
• W4386090468 modified "2023-10-10" @default.
• W4386090468 title "Targeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss" @default.
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• W4386090468 cites W1999428972 @default.
• W4386090468 cites W2000682075 @default.
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• W4386090468 cites W2008790622 @default.
• W4386090468 cites W2026181838 @default.
• W4386090468 cites W2029156712 @default.
• W4386090468 cites W2051314902 @default.
• W4386090468 cites W2068132526 @default.
• W4386090468 cites W2073298576 @default.
• W4386090468 cites W2083248417 @default.
• W4386090468 cites W2084074052 @default.
• W4386090468 cites W2096425957 @default.
• W4386090468 cites W2100641053 @default.
• W4386090468 cites W2107326562 @default.
• W4386090468 cites W2111854851 @default.
• W4386090468 cites W2119125643 @default.
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• W4386090468 cites W2344690820 @default.
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• W4386090468 cites W2567412160 @default.
• W4386090468 cites W2616658238 @default.
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• W4386090468 cites W2794287029 @default.
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• W4386090468 doi "https://doi.org/10.1126/scitranslmed.adg3983" @default.
• W4386090468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37611084" @default.
• W4386090468 hasPublicationYear "2023" @default.
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