Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386090908> ?p ?o ?g. }
- W4386090908 abstract "Abstract The exogenous excitation requirement and electron-hole recombination are the key elements limiting the application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi 0.5 Sb 1.5 Te 3 /CaO 2 nanosheets, BST/CaO 2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, the CaO 2 coating undergoes rapid hydrolysis, releasing Ca 2+ , H 2 O 2 , and heat. The resulting temperature difference on the BST NSs initiates a thermoelectric effect, driving reactive oxygen species production. H 2 O 2 not only serves as a substrate supplement for ROS generation but also dysregulates Ca 2+ channels, preventing Ca 2+ efflux. This further exacerbates calcium overload-mediated therapy. Additionally, Ca 2+ promotes DC maturation and tumor antigen presentation, facilitating immunotherapy. It is worth noting that the CaO 2 NP coating hydrolyzes very slowly in normal cells, releasing Ca 2+ and O 2 without causing any adverse effects. Tumor-specific self-triggered thermoelectric nanoheterojunction combined catalytic therapy, ion interference therapy, and immunotherapy exhibit excellent antitumor performance in female mice." @default.
- W4386090908 created "2023-08-24" @default.
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- W4386090908 date "2023-08-23" @default.
- W4386090908 modified "2023-09-26" @default.
- W4386090908 title "Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy" @default.
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- W4386090908 doi "https://doi.org/10.1038/s41467-023-40954-y" @default.
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- W4386090908 hasPublicationYear "2023" @default.
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