Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386091004> ?p ?o ?g. }
- W4386091004 abstract "Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb motor function. Acetylglutamine (N-acetyl-L-glutamine, NAG) has been proven to exert neuroprotective and anti-inflammatory effects on various disorders of the nervous system. Thus, the present study mainly focused on the influence of NAG on motor and sensory recovery after BPRA in rats and the underlying mechanisms.Male adult Sprague Dawley (SD) rats were subjected to BPRA and reimplantation surgery and subsequently treated with NAG or saline. Behavioral tests were conducted to evaluate motor function recovery and the mechanical pain threshold of the affected forelimb. The morphological appearance of the spinal cord, musculocutaneous nerve, and biceps brachii was assessed by histological staining. Quantitative real-time PCR (qRT‒PCR) was used to measure the mRNA levels of remyelination and regeneration indicators in myocutaneous nerves. The protein levels of inflammatory and pyroptotic indicators in the spinal cord anterior horn were measured using Western blotting.NAG significantly accelerated the recovery of motor function in the injured forelimbs, enhanced motoneuronal survival in the anterior horn of the spinal cord, inhibited the expression of proinflammatory cytokines and pyroptosis pathway factors, facilitated axonal remyelination in the myocutaneous nerve and alleviated atrophy of the biceps brachii. Additionally, NAG attenuated neuropathic pain following BPRA.NAG promotes functional motor recovery and alleviates neuropathic pain by enhancing motoneuronal survival and axonal remyelination and inhibiting the pyroptosis pathway after BPRA in rats, laying the foundation for the use of NAG as a novel treatment for BPRA." @default.
- W4386091004 created "2023-08-24" @default.
- W4386091004 creator A5016797934 @default.
- W4386091004 creator A5024612625 @default.
- W4386091004 creator A5027459729 @default.
- W4386091004 creator A5028837344 @default.
- W4386091004 creator A5044734672 @default.
- W4386091004 creator A5051975056 @default.
- W4386091004 creator A5052197255 @default.
- W4386091004 creator A5056611624 @default.
- W4386091004 creator A5064049313 @default.
- W4386091004 creator A5083453098 @default.
- W4386091004 creator A5086326134 @default.
- W4386091004 date "2023-08-23" @default.
- W4386091004 modified "2023-09-27" @default.
- W4386091004 title "Acetylglutamine facilitates motor recovery and alleviates neuropathic pain after brachial plexus root avulsion in rats" @default.
- W4386091004 cites W1433464383 @default.
- W4386091004 cites W1932565198 @default.
- W4386091004 cites W1965120966 @default.
- W4386091004 cites W1965686148 @default.
- W4386091004 cites W1967826700 @default.
- W4386091004 cites W1975002537 @default.
- W4386091004 cites W1982047183 @default.
- W4386091004 cites W1996269697 @default.
- W4386091004 cites W2017930992 @default.
- W4386091004 cites W2032160844 @default.
- W4386091004 cites W2033818333 @default.
- W4386091004 cites W2042189730 @default.
- W4386091004 cites W2057902826 @default.
- W4386091004 cites W2099505205 @default.
- W4386091004 cites W2211502985 @default.
- W4386091004 cites W2286896725 @default.
- W4386091004 cites W2354612635 @default.
- W4386091004 cites W2520221904 @default.
- W4386091004 cites W2602788553 @default.
- W4386091004 cites W2609903142 @default.
- W4386091004 cites W2626567585 @default.
- W4386091004 cites W2808597917 @default.
- W4386091004 cites W2890456845 @default.
- W4386091004 cites W2898202935 @default.
- W4386091004 cites W2904720488 @default.
- W4386091004 cites W2913428618 @default.
- W4386091004 cites W2914313406 @default.
- W4386091004 cites W2921620566 @default.
- W4386091004 cites W2930918897 @default.
- W4386091004 cites W2981097760 @default.
- W4386091004 cites W2992413241 @default.
- W4386091004 cites W3012596664 @default.
- W4386091004 cites W3023675417 @default.
- W4386091004 cites W3036844691 @default.
- W4386091004 cites W3048279753 @default.
- W4386091004 cites W3103725605 @default.
- W4386091004 cites W3145689790 @default.
- W4386091004 cites W3195197337 @default.
- W4386091004 doi "https://doi.org/10.1186/s12967-023-04399-7" @default.
- W4386091004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37612586" @default.
- W4386091004 hasPublicationYear "2023" @default.
- W4386091004 type Work @default.
- W4386091004 citedByCount "0" @default.
- W4386091004 crossrefType "journal-article" @default.
- W4386091004 hasAuthorship W4386091004A5016797934 @default.
- W4386091004 hasAuthorship W4386091004A5024612625 @default.
- W4386091004 hasAuthorship W4386091004A5027459729 @default.
- W4386091004 hasAuthorship W4386091004A5028837344 @default.
- W4386091004 hasAuthorship W4386091004A5044734672 @default.
- W4386091004 hasAuthorship W4386091004A5051975056 @default.
- W4386091004 hasAuthorship W4386091004A5052197255 @default.
- W4386091004 hasAuthorship W4386091004A5056611624 @default.
- W4386091004 hasAuthorship W4386091004A5064049313 @default.
- W4386091004 hasAuthorship W4386091004A5083453098 @default.
- W4386091004 hasAuthorship W4386091004A5086326134 @default.
- W4386091004 hasBestOaLocation W43860910041 @default.
- W4386091004 hasConcept C105702510 @default.
- W4386091004 hasConcept C118552586 @default.
- W4386091004 hasConcept C126322002 @default.
- W4386091004 hasConcept C164027704 @default.
- W4386091004 hasConcept C25498285 @default.
- W4386091004 hasConcept C2776914184 @default.
- W4386091004 hasConcept C2777107010 @default.
- W4386091004 hasConcept C2777619251 @default.
- W4386091004 hasConcept C2778334475 @default.
- W4386091004 hasConcept C2778609137 @default.
- W4386091004 hasConcept C2779530196 @default.
- W4386091004 hasConcept C2780775167 @default.
- W4386091004 hasConcept C2781151446 @default.
- W4386091004 hasConcept C2781425419 @default.
- W4386091004 hasConcept C42219234 @default.
- W4386091004 hasConcept C529278444 @default.
- W4386091004 hasConcept C64348767 @default.
- W4386091004 hasConcept C71924100 @default.
- W4386091004 hasConceptScore W4386091004C105702510 @default.
- W4386091004 hasConceptScore W4386091004C118552586 @default.
- W4386091004 hasConceptScore W4386091004C126322002 @default.
- W4386091004 hasConceptScore W4386091004C164027704 @default.
- W4386091004 hasConceptScore W4386091004C25498285 @default.
- W4386091004 hasConceptScore W4386091004C2776914184 @default.
- W4386091004 hasConceptScore W4386091004C2777107010 @default.
- W4386091004 hasConceptScore W4386091004C2777619251 @default.
- W4386091004 hasConceptScore W4386091004C2778334475 @default.
- W4386091004 hasConceptScore W4386091004C2778609137 @default.