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- W4386094612 abstract "Changes in the oral microbiome may contribute to oral pathologies, especially in patients undergoing cancer therapy. Interactions between oral microbiome and oral mucosa may exacerbate inflammation. We determined whether probiotic-controlled plaque formation could impact proximal oral mucosa gene expression profiles in healthy volunteers. A 3-weeks balanced sample collection design from healthy volunteers (HVs) was implemented. At Week-1 plaques samples and labial mucosa brush biopsies were obtained from HVs in the morning (N = 4) and/or in the afternoon (N = 4), and groups were flipped at Week-3. A fruit yogurt and tea diet were given 2-4hrs before sample collection. mRNA gene expression analysis was completed using RNA-Seq and DESeq2. Bacterial taxa relative abundance was determined by 16S HOMINGS. Bacterial diversity changes and metabolic pathway enrichment were determined using PRIMERv7 and LEfSe programs. Alpha- and beta-diversities did not differ morning (AM) vs. afternoon (PM). The most affected KEGG pathway was Toll-like receptor signaling in oral mucosa. Eighteen human genes and nine bacterial genes were differentially expressed in plaque samples. Increased activity for 'caries-free' health-associated calcifying Corynebacterium matruchotii and reduced activity for Aggregatibacter aphrophilus, an opportunistic pathogen, were observed. Microbial diversity was not altered after 8 hours plaque formation in healthy individuals as opposed to gene expression." @default.
- W4386094612 created "2023-08-24" @default.
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- W4386094612 date "2023-08-22" @default.
- W4386094612 modified "2023-09-23" @default.
- W4386094612 title "Human oral mucosa and oral microbiome interactions following supragingival plaque reconstitution in healthy volunteers: a diet-controlled balanced design proof-of-concept model to investigate oral pathologies" @default.
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- W4386094612 cites W2035751355 @default.
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- W4386094612 cites W2096173332 @default.
- W4386094612 cites W2096786319 @default.
- W4386094612 cites W2102278586 @default.
- W4386094612 cites W2107779823 @default.
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- W4386094612 doi "https://doi.org/10.1080/20002297.2023.2246279" @default.
- W4386094612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37621744" @default.
- W4386094612 hasPublicationYear "2023" @default.
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