FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386095360> ?p ?o ?g. }

• W4386095360 abstract "Abstract Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO 2 . This is proposed to be mediated through carbamylation of K125. We show that mutating K125 to glutamate, mimicking the negative charge of carbamylation, causes Cx26 GJCs to be constitutively closed. Through cryo-EM we observe that the K125E mutation pushes a conformational equilibrium towards the channel having a constricted pore entrance, similar to effects seen on raising the partial pressure of CO 2 . In previous structures of connexins, the cytoplasmic loop, important in regulation and where K125 is located, is disordered. Through further cryo-EM studies we trap distinct states of Cx26 and observe density for the cytoplasmic loop. The interplay between the position of this loop, the conformations of the transmembrane helices and the position of the N-terminal helix, which controls the aperture to the pore, provides a mechanism for regulation." @default.
• W4386095360 created "2023-08-24" @default.
• W4386095360 creator A5006048680 @default.
• W4386095360 creator A5013296863 @default.
• W4386095360 creator A5018690973 @default.
• W4386095360 creator A5052160114 @default.
• W4386095360 creator A5063483944 @default.
• W4386095360 date "2023-08-22" @default.
• W4386095360 modified "2023-09-26" @default.
• W4386095360 title "Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO₂" @default.
• W4386095360 cites W1509467885 @default.
• W4386095360 cites W1963694848 @default.
• W4386095360 cites W1992576846 @default.
• W4386095360 cites W1996083272 @default.
• W4386095360 cites W2000948394 @default.
• W4386095360 cites W2004688423 @default.
• W4386095360 cites W2011908808 @default.
• W4386095360 cites W2049654315 @default.
• W4386095360 cites W2062392701 @default.
• W4386095360 cites W2064140868 @default.
• W4386095360 cites W2085924667 @default.
• W4386095360 cites W2098338329 @default.
• W4386095360 cites W2104234755 @default.
• W4386095360 cites W2105320550 @default.
• W4386095360 cites W2105664925 @default.
• W4386095360 cites W2129483036 @default.
• W4386095360 cites W2132629607 @default.
• W4386095360 cites W2144081223 @default.
• W4386095360 cites W2148369606 @default.
• W4386095360 cites W2151146999 @default.
• W4386095360 cites W2152562710 @default.
• W4386095360 cites W2255989330 @default.
• W4386095360 cites W2583803303 @default.
• W4386095360 cites W2593511418 @default.
• W4386095360 cites W2899714098 @default.
• W4386095360 cites W2904888175 @default.
• W4386095360 cites W2953320394 @default.
• W4386095360 cites W2973457155 @default.
• W4386095360 cites W3006000566 @default.
• W4386095360 cites W3016892808 @default.
• W4386095360 cites W3048441510 @default.
• W4386095360 cites W3081876028 @default.
• W4386095360 cites W3081918697 @default.
• W4386095360 cites W3091768504 @default.
• W4386095360 cites W3177828909 @default.
• W4386095360 cites W3211795435 @default.
• W4386095360 cites W4206563428 @default.
• W4386095360 cites W4220751637 @default.
• W4386095360 cites W4321328182 @default.
• W4386095360 cites W4323820861 @default.
• W4386095360 cites W4323923746 @default.
• W4386095360 cites W4376663831 @default.
• W4386095360 cites W4377693433 @default.
• W4386095360 doi "https://doi.org/10.1101/2023.08.22.554292" @default.
• W4386095360 hasPublicationYear "2023" @default.
• W4386095360 type Work @default.
• W4386095360 citedByCount "0" @default.
• W4386095360 crossrefType "posted-content" @default.
• W4386095360 hasAuthorship W4386095360A5006048680 @default.
• W4386095360 hasAuthorship W4386095360A5013296863 @default.
• W4386095360 hasAuthorship W4386095360A5018690973 @default.
• W4386095360 hasAuthorship W4386095360A5052160114 @default.
• W4386095360 hasAuthorship W4386095360A5063483944 @default.
• W4386095360 hasBestOaLocation W43860953601 @default.
• W4386095360 hasConcept C10138342 @default.
• W4386095360 hasConcept C104317684 @default.
• W4386095360 hasConcept C114614502 @default.
• W4386095360 hasConcept C118892022 @default.
• W4386095360 hasConcept C12554922 @default.
• W4386095360 hasConcept C143065580 @default.
• W4386095360 hasConcept C162324750 @default.
• W4386095360 hasConcept C170493617 @default.
• W4386095360 hasConcept C184670325 @default.
• W4386095360 hasConcept C185592680 @default.
• W4386095360 hasConcept C18903297 @default.
• W4386095360 hasConcept C190062978 @default.
• W4386095360 hasConcept C198082294 @default.
• W4386095360 hasConcept C24530287 @default.
• W4386095360 hasConcept C2778530040 @default.
• W4386095360 hasConcept C2779965526 @default.
• W4386095360 hasConcept C33923547 @default.
• W4386095360 hasConcept C41625074 @default.
• W4386095360 hasConcept C55493867 @default.
• W4386095360 hasConcept C86803240 @default.
• W4386095360 hasConceptScore W4386095360C10138342 @default.
• W4386095360 hasConceptScore W4386095360C104317684 @default.
• W4386095360 hasConceptScore W4386095360C114614502 @default.
• W4386095360 hasConceptScore W4386095360C118892022 @default.
• W4386095360 hasConceptScore W4386095360C12554922 @default.
• W4386095360 hasConceptScore W4386095360C143065580 @default.
• W4386095360 hasConceptScore W4386095360C162324750 @default.
• W4386095360 hasConceptScore W4386095360C170493617 @default.
• W4386095360 hasConceptScore W4386095360C184670325 @default.
• W4386095360 hasConceptScore W4386095360C185592680 @default.
• W4386095360 hasConceptScore W4386095360C18903297 @default.
• W4386095360 hasConceptScore W4386095360C190062978 @default.
• W4386095360 hasConceptScore W4386095360C198082294 @default.
• W4386095360 hasConceptScore W4386095360C24530287 @default.
• W4386095360 hasConceptScore W4386095360C2778530040 @default.
• W4386095360 hasConceptScore W4386095360C2779965526 @default.

• next