Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386095600> ?p ?o ?g. }
- W4386095600 abstract "Abstract Infections and vaccinations can induce long-term enhanced responses of innate immune cells to heterologous stimuli, establishing a de facto innate immunological memory termed trained immunity . Monocytes exposed to the Bacillus Calmette-Guérin (BCG) vaccine, have a trained immunity phenotype, characterized by an increased biosynthesis of different lipid mediators (LMs) derived from long-chain polyunsaturated fatty acids (PUFAs). Pharmacological and genetic approaches showed that long-chain PUFA synthesis and lipoxygenase (LOX)-derived LMs are crucial for the BCG trained immunity responses of human monocytes. Furthermore, monocytes of healthy individuals vaccinated with BCG are enriched in 12-LOX products. The elucidation of the lipid metabolic pathways that promote innate immune memory contributes to our understanding of trained immunity and may help identify therapeutic tools and targets for the modulation of innate immune responses." @default.
- W4386095600 created "2023-08-24" @default.
- W4386095600 creator A5004927110 @default.
- W4386095600 creator A5009969152 @default.
- W4386095600 creator A5014498664 @default.
- W4386095600 creator A5017907898 @default.
- W4386095600 creator A5022140103 @default.
- W4386095600 creator A5025931645 @default.
- W4386095600 creator A5026554824 @default.
- W4386095600 creator A5027955775 @default.
- W4386095600 creator A5030219128 @default.
- W4386095600 creator A5030845823 @default.
- W4386095600 creator A5042448808 @default.
- W4386095600 creator A5053742404 @default.
- W4386095600 creator A5075715692 @default.
- W4386095600 creator A5076024704 @default.
- W4386095600 creator A5076453023 @default.
- W4386095600 creator A5080542606 @default.
- W4386095600 creator A5082586502 @default.
- W4386095600 date "2023-08-22" @default.
- W4386095600 modified "2023-09-26" @default.
- W4386095600 title "Fatty acid desaturation and lipoxygenase pathways support trained immunity" @default.
- W4386095600 cites W1466493721 @default.
- W4386095600 cites W1564315843 @default.
- W4386095600 cites W1966584984 @default.
- W4386095600 cites W1992764470 @default.
- W4386095600 cites W1994063461 @default.
- W4386095600 cites W2002099481 @default.
- W4386095600 cites W2004536682 @default.
- W4386095600 cites W2033058272 @default.
- W4386095600 cites W2044853635 @default.
- W4386095600 cites W2046390589 @default.
- W4386095600 cites W2059344017 @default.
- W4386095600 cites W2059403792 @default.
- W4386095600 cites W2062147513 @default.
- W4386095600 cites W2067031028 @default.
- W4386095600 cites W2074780993 @default.
- W4386095600 cites W2095474336 @default.
- W4386095600 cites W2100697281 @default.
- W4386095600 cites W2102189561 @default.
- W4386095600 cites W2103010344 @default.
- W4386095600 cites W2103028385 @default.
- W4386095600 cites W2115893060 @default.
- W4386095600 cites W2128337342 @default.
- W4386095600 cites W2135186594 @default.
- W4386095600 cites W2137449697 @default.
- W4386095600 cites W2143625465 @default.
- W4386095600 cites W2145946501 @default.
- W4386095600 cites W2167840222 @default.
- W4386095600 cites W2257210332 @default.
- W4386095600 cites W2412442244 @default.
- W4386095600 cites W2548555233 @default.
- W4386095600 cites W2587397267 @default.
- W4386095600 cites W2621132409 @default.
- W4386095600 cites W2765422662 @default.
- W4386095600 cites W2782649526 @default.
- W4386095600 cites W2783037826 @default.
- W4386095600 cites W2784008489 @default.
- W4386095600 cites W2901450361 @default.
- W4386095600 cites W2919386583 @default.
- W4386095600 cites W2953909155 @default.
- W4386095600 cites W2961187239 @default.
- W4386095600 cites W2976785843 @default.
- W4386095600 cites W2985135727 @default.
- W4386095600 cites W3010882691 @default.
- W4386095600 cites W3013039932 @default.
- W4386095600 cites W3017333705 @default.
- W4386095600 cites W3041021461 @default.
- W4386095600 cites W3044571009 @default.
- W4386095600 cites W3044949069 @default.
- W4386095600 cites W3098123994 @default.
- W4386095600 cites W3106444534 @default.
- W4386095600 cites W3112590295 @default.
- W4386095600 cites W3115243203 @default.
- W4386095600 cites W3122324184 @default.
- W4386095600 cites W3131308878 @default.
- W4386095600 cites W3133707341 @default.
- W4386095600 cites W3196324598 @default.
- W4386095600 cites W3200790334 @default.
- W4386095600 cites W3200970588 @default.
- W4386095600 doi "https://doi.org/10.1101/2023.08.22.554295" @default.
- W4386095600 hasPublicationYear "2023" @default.
- W4386095600 type Work @default.
- W4386095600 citedByCount "0" @default.
- W4386095600 crossrefType "posted-content" @default.
- W4386095600 hasAuthorship W4386095600A5004927110 @default.
- W4386095600 hasAuthorship W4386095600A5009969152 @default.
- W4386095600 hasAuthorship W4386095600A5014498664 @default.
- W4386095600 hasAuthorship W4386095600A5017907898 @default.
- W4386095600 hasAuthorship W4386095600A5022140103 @default.
- W4386095600 hasAuthorship W4386095600A5025931645 @default.
- W4386095600 hasAuthorship W4386095600A5026554824 @default.
- W4386095600 hasAuthorship W4386095600A5027955775 @default.
- W4386095600 hasAuthorship W4386095600A5030219128 @default.
- W4386095600 hasAuthorship W4386095600A5030845823 @default.
- W4386095600 hasAuthorship W4386095600A5042448808 @default.
- W4386095600 hasAuthorship W4386095600A5053742404 @default.
- W4386095600 hasAuthorship W4386095600A5075715692 @default.
- W4386095600 hasAuthorship W4386095600A5076024704 @default.
- W4386095600 hasAuthorship W4386095600A5076453023 @default.