Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386096004> ?p ?o ?g. }
- W4386096004 abstract "The evolution of lymphoma is a multifactorial process that leads to unavoidable lymphoma heterogeneity in the form of genetic mutations, chromosomal translocations and other variations. Multi‑omics analyses based on single‑cell assays can reveal and characterize tumor components, enabling us to determine the timing of mutations and to profile disease progression. Increasing numbers of studies are using single‑cell transcriptomics to unravel the mechanisms of lymphoma evolution, drug resistance and therapeutic approaches. Various single‑cell multi‑omics measurements involving genomics, transcriptomics and epigenomics have improved knowledge of the complex lymphatic system and made it possible to obtain individualized and precise tumor biological characteristics, which cannot be accessed from bulk cell analysis, and this can facilitate individualized treatment. In the present review, the advances in multi‑omics analysis based on single‑cell assays of lymphoma specimens were systematically discussed, including the sequencing of the single‑cell from genomic and transcriptomic perspectives, the landscape of the lymphoma microenvironment, the development of single‑cell histology biomarkers, the identification of lymphoma origin and evolution, as well as the current challenges and future prospects of single‑cell multi‑omics. The authors' insights may contribute to the exploration of novel lymphoma biomarkers and the discovery of efficient treatment combinations that target immunological checkpoints and underlying molecular mechanisms." @default.
- W4386096004 created "2023-08-24" @default.
- W4386096004 creator A5010710133 @default.
- W4386096004 creator A5052763183 @default.
- W4386096004 creator A5075444455 @default.
- W4386096004 creator A5077381400 @default.
- W4386096004 creator A5079393105 @default.
- W4386096004 date "2023-08-23" @default.
- W4386096004 modified "2023-10-01" @default.
- W4386096004 title "Single‑cell multi‑omics advances in lymphoma research (Review)" @default.
- W4386096004 cites W1107917109 @default.
- W4386096004 cites W1529154539 @default.
- W4386096004 cites W1554337334 @default.
- W4386096004 cites W1556498576 @default.
- W4386096004 cites W1974010997 @default.
- W4386096004 cites W1977948948 @default.
- W4386096004 cites W1978390586 @default.
- W4386096004 cites W1985987855 @default.
- W4386096004 cites W2004232113 @default.
- W4386096004 cites W2010329820 @default.
- W4386096004 cites W2018761956 @default.
- W4386096004 cites W2045919693 @default.
- W4386096004 cites W2053279156 @default.
- W4386096004 cites W2062010511 @default.
- W4386096004 cites W2071010503 @default.
- W4386096004 cites W2072478189 @default.
- W4386096004 cites W2090461073 @default.
- W4386096004 cites W2090505632 @default.
- W4386096004 cites W2102212449 @default.
- W4386096004 cites W2118207747 @default.
- W4386096004 cites W2130410032 @default.
- W4386096004 cites W2135321054 @default.
- W4386096004 cites W2135937351 @default.
- W4386096004 cites W2143505663 @default.
- W4386096004 cites W2147246240 @default.
- W4386096004 cites W2153422981 @default.
- W4386096004 cites W2153655918 @default.
- W4386096004 cites W2167621352 @default.
- W4386096004 cites W2176045535 @default.
- W4386096004 cites W2216217499 @default.
- W4386096004 cites W2286667211 @default.
- W4386096004 cites W2310588915 @default.
- W4386096004 cites W2314405812 @default.
- W4386096004 cites W2314481096 @default.
- W4386096004 cites W2339658711 @default.
- W4386096004 cites W2346545043 @default.
- W4386096004 cites W2441107086 @default.
- W4386096004 cites W2477644871 @default.
- W4386096004 cites W2557155700 @default.
- W4386096004 cites W2565912540 @default.
- W4386096004 cites W2580989000 @default.
- W4386096004 cites W2588569583 @default.
- W4386096004 cites W2593312604 @default.
- W4386096004 cites W2625300447 @default.
- W4386096004 cites W2739492614 @default.
- W4386096004 cites W2745713794 @default.
- W4386096004 cites W2753908609 @default.
- W4386096004 cites W2766437506 @default.
- W4386096004 cites W2793344857 @default.
- W4386096004 cites W2795624730 @default.
- W4386096004 cites W2800028441 @default.
- W4386096004 cites W2800402965 @default.
- W4386096004 cites W2801175520 @default.
- W4386096004 cites W2803178717 @default.
- W4386096004 cites W2803775493 @default.
- W4386096004 cites W2807986422 @default.
- W4386096004 cites W2811417740 @default.
- W4386096004 cites W2887022419 @default.
- W4386096004 cites W2889758918 @default.
- W4386096004 cites W2895272189 @default.
- W4386096004 cites W2900272452 @default.
- W4386096004 cites W2902093381 @default.
- W4386096004 cites W2906738980 @default.
- W4386096004 cites W2906764941 @default.
- W4386096004 cites W2913008832 @default.
- W4386096004 cites W2913421577 @default.
- W4386096004 cites W2920660555 @default.
- W4386096004 cites W2922610698 @default.
- W4386096004 cites W2939422961 @default.
- W4386096004 cites W2940972161 @default.
- W4386096004 cites W2941372435 @default.
- W4386096004 cites W2945632419 @default.
- W4386096004 cites W2946741946 @default.
- W4386096004 cites W2951068818 @default.
- W4386096004 cites W2951506174 @default.
- W4386096004 cites W2951843883 @default.
- W4386096004 cites W2951890476 @default.
- W4386096004 cites W2953057790 @default.
- W4386096004 cites W2958475422 @default.
- W4386096004 cites W2966465234 @default.
- W4386096004 cites W2971474936 @default.
- W4386096004 cites W2987148655 @default.
- W4386096004 cites W2994693426 @default.
- W4386096004 cites W3007237653 @default.
- W4386096004 cites W3007632958 @default.
- W4386096004 cites W3010668776 @default.
- W4386096004 cites W3010678440 @default.
- W4386096004 cites W3024364746 @default.
- W4386096004 cites W3035551042 @default.
- W4386096004 cites W3037023631 @default.