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- W4386096148 abstract "The nucleolus is a multi-functional nuclear body. To tease out the roles of nucleolar structure without resorting to the use of multi-action drugs, we knocked down the RNA polymerase I subunit RPA194 in HeLa cells by siRNA. Loss of RPA194 resulted in nucleolar structural segregation and effects on both nucleolus-proximal and distal nuclear components. The perinucleolar compartment was disrupted, centromere clustering around nucleoli was significantly reduced, and the intranuclear locations of specific genomic loci were altered. Moreover, Cajal bodies, distal from nucleoli, underwent morphological and some compositional changes. In comparison, when the pre-ribosomal RNA processing factor, UTP4, was knocked down, neither nucleolar segregation nor the intranuclear effects were observed, demonstrating that the changes of nucleolar proximal and distal nuclear domains in RPA194 knockdown cells unlikely arise from a cessation of ribosome synthesis, rather from the consequence of nucleolar structure alteration. These findings point to a commutative system that links nucleolar structure to the maintenance and spatial organization of certain nuclear domains and genomic loci." @default.
- W4386096148 created "2023-08-24" @default.
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- W4386096148 date "2023-08-23" @default.
- W4386096148 modified "2023-10-16" @default.
- W4386096148 title "Nucleolar structure connects with global nuclear organization" @default.
- W4386096148 doi "https://doi.org/10.1091/mbc.e23-02-0062" @default.
- W4386096148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37610836" @default.
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