Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386098265> ?p ?o ?g. }
- W4386098265 endingPage "13098" @default.
- W4386098265 startingPage "13098" @default.
- W4386098265 abstract "Infection with hepatitis B virus (HBV) is a main risk factor for hepatocellular carcinoma (HCC). Extracellular vesicles, such as exosomes, play an important role in tumor development and metastasis, including regulation of HBV-related HCC. In this study, we have characterized exosome microRNA and proteins released in vitro from hepatitis B virus (HBV)-related HCC cell lines SNU-423 and SNU-182 and immortalized normal hepatocyte cell lines (THLE2 and THLE3) using microRNA sequencing and mass spectrometry. Bioinformatics, including functional enrichment and network analysis, combined with survival analysis using data related to HCC in The Cancer Genome Atlas (TCGA) database, were applied to examine the prognostic significance of the results. More than 40 microRNAs and 200 proteins were significantly dysregulated (p < 0.05) in the exosomes released from HCC cells in comparison with the normal liver cells. The functional analysis of the differentially expressed exosomal miRNAs (i.e., mir-483, mir-133a, mir-34a, mir-155, mir-183, mir-182), their predicted targets, and exosomal differentially expressed proteins (i.e., POSTN, STAM, EXOC8, SNX9, COL1A2, IDH1, FN1) showed correlation with pathways associated with HBV, virus activity and invasion, exosome formation and adhesion, and exogenous protein binding. The results from this study may help in our understanding of the role of HBV infection in the development of HCC and in the development of new targets for treatment or non-invasive predictive biomarkers of HCC." @default.
- W4386098265 created "2023-08-24" @default.
- W4386098265 creator A5000495712 @default.
- W4386098265 creator A5002003454 @default.
- W4386098265 creator A5005269465 @default.
- W4386098265 creator A5035086429 @default.
- W4386098265 creator A5044402904 @default.
- W4386098265 creator A5060298788 @default.
- W4386098265 creator A5074105390 @default.
- W4386098265 creator A5078568167 @default.
- W4386098265 creator A5081336587 @default.
- W4386098265 creator A5084348183 @default.
- W4386098265 creator A5086417088 @default.
- W4386098265 creator A5092680782 @default.
- W4386098265 date "2023-08-23" @default.
- W4386098265 modified "2023-09-27" @default.
- W4386098265 title "Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells" @default.
- W4386098265 cites W1516497807 @default.
- W4386098265 cites W1589968217 @default.
- W4386098265 cites W1609044025 @default.
- W4386098265 cites W1611220303 @default.
- W4386098265 cites W1953186510 @default.
- W4386098265 cites W1964915114 @default.
- W4386098265 cites W1968812902 @default.
- W4386098265 cites W1980389572 @default.
- W4386098265 cites W1983401107 @default.
- W4386098265 cites W1984183317 @default.
- W4386098265 cites W1990130117 @default.
- W4386098265 cites W2002156709 @default.
- W4386098265 cites W2002696889 @default.
- W4386098265 cites W2003359269 @default.
- W4386098265 cites W2004442803 @default.
- W4386098265 cites W2006798082 @default.
- W4386098265 cites W2015162003 @default.
- W4386098265 cites W2015556811 @default.
- W4386098265 cites W2034595398 @default.
- W4386098265 cites W2035422738 @default.
- W4386098265 cites W2035508730 @default.
- W4386098265 cites W2036073789 @default.
- W4386098265 cites W2041389505 @default.
- W4386098265 cites W2041905383 @default.
- W4386098265 cites W2043892409 @default.
- W4386098265 cites W2048089209 @default.
- W4386098265 cites W2048164793 @default.
- W4386098265 cites W2048613954 @default.
- W4386098265 cites W2049369927 @default.
- W4386098265 cites W2057600239 @default.
- W4386098265 cites W2063732204 @default.
- W4386098265 cites W2065486105 @default.
- W4386098265 cites W2068127752 @default.
- W4386098265 cites W2080964493 @default.
- W4386098265 cites W2084892018 @default.
- W4386098265 cites W2086351434 @default.
- W4386098265 cites W2086702949 @default.
- W4386098265 cites W2092868756 @default.
- W4386098265 cites W2106528401 @default.
- W4386098265 cites W2107057287 @default.
- W4386098265 cites W2110263673 @default.
- W4386098265 cites W2113985215 @default.
- W4386098265 cites W2125974265 @default.
- W4386098265 cites W2128695497 @default.
- W4386098265 cites W2131879353 @default.
- W4386098265 cites W2133980842 @default.
- W4386098265 cites W2135686606 @default.
- W4386098265 cites W2139339448 @default.
- W4386098265 cites W2143926676 @default.
- W4386098265 cites W2146512944 @default.
- W4386098265 cites W2146743869 @default.
- W4386098265 cites W2154312575 @default.
- W4386098265 cites W2155227852 @default.
- W4386098265 cites W2157715173 @default.
- W4386098265 cites W2213848118 @default.
- W4386098265 cites W2259481044 @default.
- W4386098265 cites W2271646263 @default.
- W4386098265 cites W2301585873 @default.
- W4386098265 cites W2339723519 @default.
- W4386098265 cites W2341117915 @default.
- W4386098265 cites W2345415005 @default.
- W4386098265 cites W2462159864 @default.
- W4386098265 cites W2473248288 @default.
- W4386098265 cites W2492690653 @default.
- W4386098265 cites W2528538594 @default.
- W4386098265 cites W2551798322 @default.
- W4386098265 cites W2582141810 @default.
- W4386098265 cites W2592093096 @default.
- W4386098265 cites W2603630537 @default.
- W4386098265 cites W2744865206 @default.
- W4386098265 cites W2747254185 @default.
- W4386098265 cites W2750641739 @default.
- W4386098265 cites W2766208450 @default.
- W4386098265 cites W2771300693 @default.
- W4386098265 cites W2783426659 @default.
- W4386098265 cites W2790701366 @default.
- W4386098265 cites W2791261365 @default.
- W4386098265 cites W2798033749 @default.
- W4386098265 cites W2798041799 @default.
- W4386098265 cites W2802105343 @default.
- W4386098265 cites W2807828500 @default.