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- W4386099553 abstract "Abstract Background Fungal keratitis is a rare, potentially sight-threatening fungal infection of the cornea, and a major global cause of visual impairment and blindness. Tintelnotia destructans , a filamentous fungus, is an unusual virulent ocular pathogen. Little is known about this fungi’s association with ophthalmological conditions and there is no standardized treatment protocol in guidelines. Case presentation: We report a rare case of T. destructans- associated keratitis in a 45-year-old woman, without history of corneal trauma and a regular contact lenses user, presenting with eye discomfort and redness. Conjunctival hyperemia and a corneal abscess located inferiorly parapupilarly with an epithelial lesion was detected and topical ciprofloxacin eye drops was initiated. In vivo confocal microscopy (IVCM) revealed fungal hyphae growing perpendicularly through the corneal collagen lamellae, suggesting keratomycosis. Culture from corneal scrapings identified the hyphomycete as T. destructans. The diagnosed corneal abscess was treated successfully with natamycin and terbinafine, resulting in symptom regression. Conclusions T. destructans is an opportunistic pathogen causing severe keratomycosis with no standardized treatment. Early diagnosis using IVCM and fungal culture, guided by in vitro susceptibility testing, can allow prompt intervention." @default.
- W4386099553 created "2023-08-24" @default.
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- W4386099553 date "2023-08-23" @default.
- W4386099553 modified "2023-09-27" @default.
- W4386099553 title "A rare case of fungal keratitis caused by Tintelnotia destructans" @default.
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- W4386099553 doi "https://doi.org/10.21203/rs.3.rs-3270075/v1" @default.
- W4386099553 hasPublicationYear "2023" @default.
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