FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386099667> ?p ?o ?g. }

• W4386099667 abstract "Abstract A prospective metabolome-wide association study revealed widespread amino acid limitation in late pregnancy is associated with early onset breast cancer. Archival third trimester pregnancy serum samples from 172 women who subsequently were diagnosed with breast cancer within 38 years after pregnancy were compared to 351 women without breast cancer. No individual metabolite differed after false discovery rate adjustment, indicating that individual metabolites are unlikely to be useful for classification or prediction. Despite this, pathway enrichment analysis showed that amino acid pathways, including lysine, arginine, proline, aspartate, asparagine, alanine, tyrosine, tryptophan, histidine, branched-chain amino acid and urea cycle, were enriched among metabolites that differed at raw p < 0.05. Several of these pathways previously were linked to breast carcinogen exposures, including dichlorodiphenyltrichloroethane and perfluorinated alkyl substances. Network analyses showed that amino acids correlated with parity and the ratio of estriol to estrone and estradiol known risk factors for breast cancer in this cohort. Overall, amino acid associations were stronger for early onset breast cancer, defined here as occurring within the first 15 years following pregnancy. Although results must be interpreted cautiously, lower amino acid concentrations for histidine, threonine and proline, and stronger associations for tryptophan, histidine, and lysine pathways with breast cancer within 15 years, suggests that amino acid limitations during late pregnancy contribute to metabolic reprogramming that is causally related to early onset breast cancer. Environmental chemical effects on nutrient sensing could account for these effects through known oncogenic mechanisms linked to nutrient stress." @default.
• W4386099667 created "2023-08-24" @default.
• W4386099667 creator A5013273562 @default.
• W4386099667 creator A5030804423 @default.
• W4386099667 creator A5032746548 @default.
• W4386099667 creator A5034639674 @default.
• W4386099667 creator A5035904189 @default.
• W4386099667 creator A5078854117 @default.
• W4386099667 creator A5084328367 @default.
• W4386099667 date "2023-08-23" @default.
• W4386099667 modified "2023-10-18" @default.
• W4386099667 title "Third Trimester Serum Amino Acid Metabolism is Associated with Maternal Breast Cancer Diagnosed within 15 years of Pregnancy" @default.
• W4386099667 cites W1775510084 @default.
• W4386099667 cites W1975621320 @default.
• W4386099667 cites W1980294831 @default.
• W4386099667 cites W2002583208 @default.
• W4386099667 cites W2012660994 @default.
• W4386099667 cites W2038239984 @default.
• W4386099667 cites W2066730977 @default.
• W4386099667 cites W2082835225 @default.
• W4386099667 cites W2118854041 @default.
• W4386099667 cites W2128120644 @default.
• W4386099667 cites W2130319566 @default.
• W4386099667 cites W2147044753 @default.
• W4386099667 cites W2165681080 @default.
• W4386099667 cites W2322580831 @default.
• W4386099667 cites W2518686384 @default.
• W4386099667 cites W2561291010 @default.
• W4386099667 cites W2739852298 @default.
• W4386099667 cites W2761314975 @default.
• W4386099667 cites W2766190419 @default.
• W4386099667 cites W2770064850 @default.
• W4386099667 cites W2789852907 @default.
• W4386099667 cites W2821028017 @default.
• W4386099667 cites W2889432911 @default.
• W4386099667 cites W2946291641 @default.
• W4386099667 cites W2946537900 @default.
• W4386099667 cites W3012896294 @default.
• W4386099667 cites W3034638558 @default.
• W4386099667 cites W3093725611 @default.
• W4386099667 cites W3163700464 @default.
• W4386099667 cites W3188252388 @default.
• W4386099667 cites W4242106902 @default.
• W4386099667 cites W4307462277 @default.
• W4386099667 cites W4385190425 @default.
• W4386099667 doi "https://doi.org/10.21203/rs.3.rs-3272893/v1" @default.
• W4386099667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37674716" @default.
• W4386099667 hasPublicationYear "2023" @default.
• W4386099667 type Work @default.
• W4386099667 citedByCount "0" @default.
• W4386099667 crossrefType "posted-content" @default.
• W4386099667 hasAuthorship W4386099667A5013273562 @default.
• W4386099667 hasAuthorship W4386099667A5030804423 @default.
• W4386099667 hasAuthorship W4386099667A5032746548 @default.
• W4386099667 hasAuthorship W4386099667A5034639674 @default.
• W4386099667 hasAuthorship W4386099667A5035904189 @default.
• W4386099667 hasAuthorship W4386099667A5078854117 @default.
• W4386099667 hasAuthorship W4386099667A5084328367 @default.
• W4386099667 hasBestOaLocation W43860996671 @default.
• W4386099667 hasConcept C121608353 @default.
• W4386099667 hasConcept C126322002 @default.
• W4386099667 hasConcept C134018914 @default.
• W4386099667 hasConcept C135870905 @default.
• W4386099667 hasConcept C185592680 @default.
• W4386099667 hasConcept C2777335581 @default.
• W4386099667 hasConcept C2777477808 @default.
• W4386099667 hasConcept C2779234561 @default.
• W4386099667 hasConcept C2779349466 @default.
• W4386099667 hasConcept C42407357 @default.
• W4386099667 hasConcept C515207424 @default.
• W4386099667 hasConcept C530470458 @default.
• W4386099667 hasConcept C54355233 @default.
• W4386099667 hasConcept C55493867 @default.
• W4386099667 hasConcept C71924100 @default.
• W4386099667 hasConcept C86803240 @default.
• W4386099667 hasConceptScore W4386099667C121608353 @default.
• W4386099667 hasConceptScore W4386099667C126322002 @default.
• W4386099667 hasConceptScore W4386099667C134018914 @default.
• W4386099667 hasConceptScore W4386099667C135870905 @default.
• W4386099667 hasConceptScore W4386099667C185592680 @default.
• W4386099667 hasConceptScore W4386099667C2777335581 @default.
• W4386099667 hasConceptScore W4386099667C2777477808 @default.
• W4386099667 hasConceptScore W4386099667C2779234561 @default.
• W4386099667 hasConceptScore W4386099667C2779349466 @default.
• W4386099667 hasConceptScore W4386099667C42407357 @default.
• W4386099667 hasConceptScore W4386099667C515207424 @default.
• W4386099667 hasConceptScore W4386099667C530470458 @default.
• W4386099667 hasConceptScore W4386099667C54355233 @default.
• W4386099667 hasConceptScore W4386099667C55493867 @default.
• W4386099667 hasConceptScore W4386099667C71924100 @default.
• W4386099667 hasConceptScore W4386099667C86803240 @default.
• W4386099667 hasLocation W43860996671 @default.
• W4386099667 hasLocation W43860996672 @default.
• W4386099667 hasOpenAccess W4386099667 @default.
• W4386099667 hasPrimaryLocation W43860996671 @default.
• W4386099667 hasRelatedWork W1970655517 @default.
• W4386099667 hasRelatedWork W2008264923 @default.
• W4386099667 hasRelatedWork W2021717422 @default.
• W4386099667 hasRelatedWork W2094087834 @default.
• W4386099667 hasRelatedWork W2109375501 @default.

• next