Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386100450> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4386100450 abstract "Abstract Background COVID-19 vaccines have played a critical role in controlling the COVID-19 pandemic. Although overall considered safe, COVID-19 vaccination has been associated with rare but severe thrombotic events, occurring mainly in the context of adenoviral vectored vaccines. A better understanding of mechanisms underlying vaccine-induced hypercoagulability and prothrombotic state is needed to improve vaccine safety profile. Methods We assessed changes to the biomarkers of endothelial function (endothelin, ET-1), coagulation (thrombomodulin, THBD and plasminogen activator inhibitor, PAI) and platelet activation (platelet activating factor, PAF, and platelet factor 4 IgG antibody, PF4 IgG) within a three-week period after the first (prime) and second (boost) doses of Gam-Covid-Vac, an AdV5/AdV26-vectored COVID-19 vaccine. Blood plasma collected from vaccinees (n=58) was assayed using ELISA assays. Participants were stratified by prior COVID-19 exposure based on their baseline SARS-CoV-2-specific serology results. Results We observed a significant post-prime increase in circulating ET-1, with levels sustained after the boost dose compared to baseline. ET-1 elevation following dose 2 was most pronounced in vaccinees without prior COVID-19 exposure. Prior COVID-19 was also associated with a mild increase in post-dose 1 PAI. Conclusions Vaccination was associated with elevated ET-1 up to day 21 after the second vaccine dose, while no marked alterations to other biomarkers, including PF4 IgG, were seen. A role of persistent endothelial activation followingCOVID-19 vaccination warrants further investigation." @default.
- W4386100450 created "2023-08-24" @default.
- W4386100450 creator A5000555581 @default.
- W4386100450 creator A5004918938 @default.
- W4386100450 creator A5006380346 @default.
- W4386100450 creator A5011451693 @default.
- W4386100450 creator A5012071175 @default.
- W4386100450 creator A5012361177 @default.
- W4386100450 creator A5025618316 @default.
- W4386100450 creator A5053858864 @default.
- W4386100450 creator A5062132858 @default.
- W4386100450 creator A5064372698 @default.
- W4386100450 creator A5066625736 @default.
- W4386100450 creator A5085292560 @default.
- W4386100450 creator A5086039635 @default.
- W4386100450 creator A5092681238 @default.
- W4386100450 creator A5092681239 @default.
- W4386100450 date "2023-08-23" @default.
- W4386100450 modified "2023-09-27" @default.
- W4386100450 title "The impact of Gam-COVID-Vac, an AdV5/AdV26 COVID-19 vaccine, on the biomarkers of endothelial function, coagulation and platelet activation" @default.
- W4386100450 cites W2106843173 @default.
- W4386100450 cites W3154722887 @default.
- W4386100450 cites W3194162319 @default.
- W4386100450 cites W3214928000 @default.
- W4386100450 cites W4200044199 @default.
- W4386100450 cites W4205281901 @default.
- W4386100450 cites W4210287790 @default.
- W4386100450 cites W4220906733 @default.
- W4386100450 cites W4280534425 @default.
- W4386100450 cites W4280573169 @default.
- W4386100450 cites W4288068195 @default.
- W4386100450 cites W4288692433 @default.
- W4386100450 cites W4289261854 @default.
- W4386100450 cites W4295788712 @default.
- W4386100450 cites W4298003846 @default.
- W4386100450 cites W4317214487 @default.
- W4386100450 cites W4379797403 @default.
- W4386100450 doi "https://doi.org/10.1101/2023.08.22.23294400" @default.
- W4386100450 hasPublicationYear "2023" @default.
- W4386100450 type Work @default.
- W4386100450 citedByCount "0" @default.
- W4386100450 crossrefType "posted-content" @default.
- W4386100450 hasAuthorship W4386100450A5000555581 @default.
- W4386100450 hasAuthorship W4386100450A5004918938 @default.
- W4386100450 hasAuthorship W4386100450A5006380346 @default.
- W4386100450 hasAuthorship W4386100450A5011451693 @default.
- W4386100450 hasAuthorship W4386100450A5012071175 @default.
- W4386100450 hasAuthorship W4386100450A5012361177 @default.
- W4386100450 hasAuthorship W4386100450A5025618316 @default.
- W4386100450 hasAuthorship W4386100450A5053858864 @default.
- W4386100450 hasAuthorship W4386100450A5062132858 @default.
- W4386100450 hasAuthorship W4386100450A5064372698 @default.
- W4386100450 hasAuthorship W4386100450A5066625736 @default.
- W4386100450 hasAuthorship W4386100450A5085292560 @default.
- W4386100450 hasAuthorship W4386100450A5086039635 @default.
- W4386100450 hasAuthorship W4386100450A5092681238 @default.
- W4386100450 hasAuthorship W4386100450A5092681239 @default.
- W4386100450 hasBestOaLocation W43861004501 @default.
- W4386100450 hasConcept C126322002 @default.
- W4386100450 hasConcept C151730666 @default.
- W4386100450 hasConcept C203014093 @default.
- W4386100450 hasConcept C22070199 @default.
- W4386100450 hasConcept C2776246508 @default.
- W4386100450 hasConcept C2776914184 @default.
- W4386100450 hasConcept C2778382381 @default.
- W4386100450 hasConcept C2779343474 @default.
- W4386100450 hasConcept C3018697912 @default.
- W4386100450 hasConcept C71924100 @default.
- W4386100450 hasConcept C86803240 @default.
- W4386100450 hasConcept C89560881 @default.
- W4386100450 hasConceptScore W4386100450C126322002 @default.
- W4386100450 hasConceptScore W4386100450C151730666 @default.
- W4386100450 hasConceptScore W4386100450C203014093 @default.
- W4386100450 hasConceptScore W4386100450C22070199 @default.
- W4386100450 hasConceptScore W4386100450C2776246508 @default.
- W4386100450 hasConceptScore W4386100450C2776914184 @default.
- W4386100450 hasConceptScore W4386100450C2778382381 @default.
- W4386100450 hasConceptScore W4386100450C2779343474 @default.
- W4386100450 hasConceptScore W4386100450C3018697912 @default.
- W4386100450 hasConceptScore W4386100450C71924100 @default.
- W4386100450 hasConceptScore W4386100450C86803240 @default.
- W4386100450 hasConceptScore W4386100450C89560881 @default.
- W4386100450 hasLocation W43861004501 @default.
- W4386100450 hasOpenAccess W4386100450 @default.
- W4386100450 hasPrimaryLocation W43861004501 @default.
- W4386100450 hasRelatedWork W2019823845 @default.
- W4386100450 hasRelatedWork W2041275165 @default.
- W4386100450 hasRelatedWork W2066831103 @default.
- W4386100450 hasRelatedWork W2093916658 @default.
- W4386100450 hasRelatedWork W2170809361 @default.
- W4386100450 hasRelatedWork W2392012371 @default.
- W4386100450 hasRelatedWork W2892474566 @default.
- W4386100450 hasRelatedWork W36089375 @default.
- W4386100450 hasRelatedWork W4376129094 @default.
- W4386100450 hasRelatedWork W74287153 @default.
- W4386100450 isParatext "false" @default.
- W4386100450 isRetracted "false" @default.
- W4386100450 workType "article" @default.