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• W4386100739 abstract "Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social behaviors, and many different behavioral paradigms have been used for investigating their neural circuit bases. Social behavior is highly vulnerable to brain network dysfunction caused by neurological and neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms of abnormal social behavior and potential therapeutic targets for treatment. In this review, we outline recent progress and key findings on neural circuit mechanisms underlying social behavior, with particular emphasis on rodent studies that monitor and manipulate the activity of specific circuits using modern systems neuroscience approaches. Social behavior is mediated by a distributed brain-wide network among major cortical (e.g., medial prefrontal cortex (mPFC), anterior cingulate cortex, and insular cortex (IC)) and subcortical (e.g., nucleus accumbens, basolateral amygdala (BLA), and ventral tegmental area) structures, influenced by multiple neuromodulatory systems (e.g., oxytocin, dopamine, and serotonin). We particularly draw special attention to IC as a unique cortical area that mediates multisensory integration, encoding of ongoing social interaction, social decision-making, emotion, and empathy. Additionally, a synthesis of studies investigating ASD mouse models demonstrates that dysfunctions in mPFC-BLA circuitry and neuromodulation are prominent. Pharmacological rescues by local or systemic (e.g., oral) administration of various drugs have provided valuable clues for developing new therapeutic agents for ASD. Future efforts and technological advances will push forward the next frontiers in this field, such as the elucidation of brain-wide network activity and inter-brain neural dynamics during real and virtual social interactions, and the establishment of circuit-based therapy for disorders affecting social functions." @default.
• W4386100739 created "2023-08-24" @default.
• W4386100739 creator A5001786419 @default.
• W4386100739 creator A5044782238 @default.
• W4386100739 creator A5062415269 @default.
• W4386100739 creator A5064512852 @default.
• W4386100739 creator A5089470758 @default.
• W4386100739 date "2023-08-24" @default.
• W4386100739 modified "2023-10-16" @default.
• W4386100739 title "Social circuits and their dysfunction in autism spectrum disorder" @default.
• W4386100739 cites W1015756911 @default.
• W4386100739 cites W1602757251 @default.
• W4386100739 cites W1772599872 @default.
• W4386100739 cites W1968064341 @default.
• W4386100739 cites W1970022438 @default.
• W4386100739 cites W1977206884 @default.
• W4386100739 cites W1977514547 @default.
• W4386100739 cites W1981654563 @default.
• W4386100739 cites W1982376050 @default.
• W4386100739 cites W2014756302 @default.
• W4386100739 cites W2015155463 @default.
• W4386100739 cites W2016521818 @default.
• W4386100739 cites W2019690396 @default.
• W4386100739 cites W2019924339 @default.
• W4386100739 cites W2021782736 @default.
• W4386100739 cites W2023832732 @default.
• W4386100739 cites W2025969629 @default.
• W4386100739 cites W2048168580 @default.
• W4386100739 cites W2048596172 @default.
• W4386100739 cites W2052610531 @default.
• W4386100739 cites W2064384972 @default.
• W4386100739 cites W2065016435 @default.
• W4386100739 cites W2068809501 @default.
• W4386100739 cites W2071797996 @default.
• W4386100739 cites W2072531628 @default.
• W4386100739 cites W2072652550 @default.
• W4386100739 cites W2072799373 @default.
• W4386100739 cites W2073825915 @default.
• W4386100739 cites W2075715784 @default.
• W4386100739 cites W2083856653 @default.
• W4386100739 cites W2084173546 @default.
• W4386100739 cites W2086935212 @default.
• W4386100739 cites W2089128674 @default.
• W4386100739 cites W2093135390 @default.
• W4386100739 cites W2093534314 @default.
• W4386100739 cites W2097364496 @default.
• W4386100739 cites W2099168883 @default.
• W4386100739 cites W2108858366 @default.
• W4386100739 cites W2116146623 @default.
• W4386100739 cites W2129381979 @default.
• W4386100739 cites W2131904564 @default.
• W4386100739 cites W2150382179 @default.
• W4386100739 cites W2151334233 @default.
• W4386100739 cites W2152504800 @default.
• W4386100739 cites W2154511345 @default.
• W4386100739 cites W2156891942 @default.
• W4386100739 cites W2162203550 @default.
• W4386100739 cites W2162459454 @default.
• W4386100739 cites W2162954233 @default.
• W4386100739 cites W2164671673 @default.
• W4386100739 cites W2174046044 @default.
• W4386100739 cites W2252899440 @default.
• W4386100739 cites W2345654030 @default.
• W4386100739 cites W2397596160 @default.
• W4386100739 cites W2407696122 @default.
• W4386100739 cites W2408110716 @default.
• W4386100739 cites W2409899008 @default.
• W4386100739 cites W2469306873 @default.
• W4386100739 cites W2474221784 @default.
• W4386100739 cites W2536660189 @default.
• W4386100739 cites W2546187937 @default.
• W4386100739 cites W2549144068 @default.
• W4386100739 cites W2553184579 @default.
• W4386100739 cites W2584425130 @default.
• W4386100739 cites W2594950994 @default.
• W4386100739 cites W2605768310 @default.
• W4386100739 cites W2624524674 @default.
• W4386100739 cites W2625169251 @default.
• W4386100739 cites W2626942755 @default.
• W4386100739 cites W2643238975 @default.
• W4386100739 cites W2672878424 @default.
• W4386100739 cites W2675424776 @default.
• W4386100739 cites W2732246028 @default.
• W4386100739 cites W2741054042 @default.
• W4386100739 cites W2755172008 @default.
• W4386100739 cites W2760672146 @default.
• W4386100739 cites W2767578348 @default.
• W4386100739 cites W2769156743 @default.
• W4386100739 cites W2772417881 @default.
• W4386100739 cites W2775257791 @default.
• W4386100739 cites W2783841565 @default.
• W4386100739 cites W2788837860 @default.
• W4386100739 cites W2790053528 @default.
• W4386100739 cites W2795455408 @default.
• W4386100739 cites W2799513798 @default.
• W4386100739 cites W2803922306 @default.
• W4386100739 cites W2806066696 @default.
• W4386100739 cites W2857327865 @default.
• W4386100739 cites W2887399686 @default.
• W4386100739 cites W2893120089 @default.

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