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- W4386101209 endingPage "188965" @default.
- W4386101209 startingPage "188965" @default.
- W4386101209 abstract "Mitotic catastrophe is distinct from other cell death modes due to unique nuclear alterations characterized as multi and/or micronucleation. Mitotic catastrophe is a common and virtually unavoidable consequence during cancer therapy. However, a comprehensive understanding of mitotic catastrophe remains lacking. Herein, we summarize the anticancer drugs that induce mitotic catastrophe, including microtubule-targeting agents, spindle assembly checkpoint kinase inhibitors, DNA damage agents and DNA damage response inhibitors. Based on the relationships between mitotic catastrophe and other cell death modes, we thoroughly evaluated the roles played by mitotic catastrophe in cancer treatment as well as its advantages and disadvantages. Some strategies for overcoming its shortcomings while fully utilizing its advantages are summarized and proposed in this review. We also review how mitotic catastrophe regulates cancer immunotherapy. These summarized findings suggest that the induction of mitotic catastrophe can serve as a promising new therapeutic approach for overcoming apoptosis resistance and strengthening cancer immunotherapy." @default.
- W4386101209 created "2023-08-24" @default.
- W4386101209 creator A5013716235 @default.
- W4386101209 creator A5019909921 @default.
- W4386101209 creator A5049506049 @default.
- W4386101209 creator A5049722747 @default.
- W4386101209 creator A5088393129 @default.
- W4386101209 date "2023-09-01" @default.
- W4386101209 modified "2023-10-16" @default.
- W4386101209 title "Perspectives and mechanisms for targeting mitotic catastrophe in cancer treatment" @default.
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