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- W4386102017 abstract "Protein homeostasis, an important aspect of cellular fitness that encompasses the balance of production, folding and degradation of proteins, has been linked to several diseases of the human body. Multiple interconnected pathways coordinate to maintain protein homeostasis within the cell. Recently, the role of the protein homeostasis network in tumorigenesis and tumour progression has gradually come to light. Here, we summarize the involvement of the most prominent components of the protein quality control mechanisms (HSR, UPS, autophagy, UPR and ERAD) in tumour development and cancer immunity. In addition, evidence for protein quality control mechanisms and targeted drugs is outlined, and attempts to combine these drugs with cancer immunotherapy are discussed. Altogether, combination therapy represents a promising direction for future investigations, and this exciting insight will be further illuminated by the development of drugs that can reach a balance between the benefits and hazards associated with protein homeostasis interference." @default.
- W4386102017 created "2023-08-24" @default.
- W4386102017 creator A5034031384 @default.
- W4386102017 creator A5046187550 @default.
- W4386102017 creator A5046508785 @default.
- W4386102017 creator A5055652318 @default.
- W4386102017 creator A5067483685 @default.
- W4386102017 creator A5067551856 @default.
- W4386102017 date "2023-10-01" @default.
- W4386102017 modified "2023-10-18" @default.
- W4386102017 title "The tumour-promoting role of protein homeostasis: Implications for cancer immunotherapy" @default.
- W4386102017 cites W1523042872 @default.
- W4386102017 cites W1538902372 @default.
- W4386102017 cites W1561349380 @default.
- W4386102017 cites W1953821950 @default.
- W4386102017 cites W1966526764 @default.
- W4386102017 cites W1970235416 @default.
- W4386102017 cites W1973562117 @default.
- W4386102017 cites W1974151922 @default.
- W4386102017 cites W1975024842 @default.
- W4386102017 cites W1976026714 @default.
- W4386102017 cites W1976582166 @default.
- W4386102017 cites W1977502249 @default.
- W4386102017 cites W1977603207 @default.
- W4386102017 cites W1979592430 @default.
- W4386102017 cites W1979821483 @default.
- W4386102017 cites W1979975605 @default.
- W4386102017 cites W1982862191 @default.
- W4386102017 cites W1987237957 @default.
- W4386102017 cites W1988548899 @default.
- W4386102017 cites W1989787517 @default.
- W4386102017 cites W1992372351 @default.
- W4386102017 cites W1997888372 @default.
- W4386102017 cites W2000929246 @default.
- W4386102017 cites W2001276434 @default.
- W4386102017 cites W2008050609 @default.
- W4386102017 cites W2011162627 @default.
- W4386102017 cites W2014220379 @default.
- W4386102017 cites W2015047561 @default.
- W4386102017 cites W2023814104 @default.
- W4386102017 cites W2026043555 @default.
- W4386102017 cites W2029109008 @default.
- W4386102017 cites W2041036769 @default.
- W4386102017 cites W2044644799 @default.
- W4386102017 cites W2044858560 @default.
- W4386102017 cites W2047642636 @default.
- W4386102017 cites W2049512057 @default.
- W4386102017 cites W2049776490 @default.
- W4386102017 cites W2054076973 @default.
- W4386102017 cites W2057499380 @default.
- W4386102017 cites W2059036087 @default.
- W4386102017 cites W2059866762 @default.
- W4386102017 cites W2061772840 @default.
- W4386102017 cites W2067530043 @default.
- W4386102017 cites W2069468418 @default.
- W4386102017 cites W2070457596 @default.
- W4386102017 cites W2072260266 @default.
- W4386102017 cites W2076194625 @default.
- W4386102017 cites W2077147012 @default.
- W4386102017 cites W2080147930 @default.
- W4386102017 cites W2081104776 @default.
- W4386102017 cites W2085758550 @default.
- W4386102017 cites W2095977490 @default.
- W4386102017 cites W2100070517 @default.
- W4386102017 cites W2102690338 @default.
- W4386102017 cites W2107154392 @default.
- W4386102017 cites W2109371953 @default.
- W4386102017 cites W2112417555 @default.
- W4386102017 cites W2112564899 @default.
- W4386102017 cites W2113558629 @default.
- W4386102017 cites W2116119295 @default.
- W4386102017 cites W2116682918 @default.
- W4386102017 cites W2116854153 @default.
- W4386102017 cites W2120049814 @default.
- W4386102017 cites W2121725556 @default.
- W4386102017 cites W2127377435 @default.
- W4386102017 cites W2133000461 @default.
- W4386102017 cites W2140197221 @default.
- W4386102017 cites W2140912399 @default.
- W4386102017 cites W2141436943 @default.
- W4386102017 cites W2141713160 @default.
- W4386102017 cites W2145388691 @default.
- W4386102017 cites W2145871366 @default.
- W4386102017 cites W2151738698 @default.
- W4386102017 cites W2152231829 @default.
- W4386102017 cites W2157360354 @default.
- W4386102017 cites W2158106840 @default.
- W4386102017 cites W2159189543 @default.
- W4386102017 cites W2164276688 @default.
- W4386102017 cites W2167882141 @default.
- W4386102017 cites W2171494370 @default.
- W4386102017 cites W2178245835 @default.
- W4386102017 cites W2194304382 @default.
- W4386102017 cites W2213407375 @default.
- W4386102017 cites W2326884456 @default.
- W4386102017 cites W2531635260 @default.
- W4386102017 cites W2532595713 @default.
- W4386102017 cites W2558103983 @default.