Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386115003> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4386115003 endingPage "71" @default.
- W4386115003 startingPage "63" @default.
- W4386115003 abstract "The goal of the current study was to formulate and evaluate mucoadhesive Dexamethasone beads to significantly lengthen the duration of the drug's stay in the GI system to treat Crohn’s disease. Dexamethasone is a corticosteroid that acts as an anti-rheumatic and anti-inflammatory. To decrease the dosage frequency Dexamethasone adhesive beads were formulated for Intimate contact with the underlying absorption surface is made possible by a prolonged stay at the location, which enhances the drug's therapeutic effectiveness. In the current study, calcium chloride and aluminium chloride were utilised as cross-linking agents to create Dexamethasone mucoadhesive beads employing adhesive polymers like sodium alginate, HPMC, and Eudragit L-100. The prepared beads' entrapment efficiencies ranged from 57.15 to 99.16%. Regarding entrapment effectiveness, particle size, surface properties, and in-vitro drug release experiments, the impact of bioadhesive polymers and cross-linking ions was assessed. The MPS-7 delayed the drug's release for 12 hours, which may be related to the cross-linking agent aluminium chloride. According to drug release kinetics, all of the formulations were more linear concerning zero order (r2=0.99) than concerning first order (r2=0.751 to 0.828). Super Case 2 Transport was discovered to be the precise release mechanism." @default.
- W4386115003 created "2023-08-24" @default.
- W4386115003 creator A5023479791 @default.
- W4386115003 creator A5092685516 @default.
- W4386115003 date "2023-08-21" @default.
- W4386115003 modified "2023-10-10" @default.
- W4386115003 title "Formulation and Evaluation of Mucoadhesive Beads of Dexamethasone" @default.
- W4386115003 doi "https://doi.org/10.26452/ijcpms.v3i2.504" @default.
- W4386115003 hasPublicationYear "2023" @default.
- W4386115003 type Work @default.
- W4386115003 citedByCount "0" @default.
- W4386115003 crossrefType "journal-article" @default.
- W4386115003 hasAuthorship W4386115003A5023479791 @default.
- W4386115003 hasAuthorship W4386115003A5092685516 @default.
- W4386115003 hasBestOaLocation W43861150031 @default.
- W4386115003 hasConcept C126322002 @default.
- W4386115003 hasConcept C178790620 @default.
- W4386115003 hasConcept C185592680 @default.
- W4386115003 hasConcept C2776634624 @default.
- W4386115003 hasConcept C2777317207 @default.
- W4386115003 hasConcept C2778695967 @default.
- W4386115003 hasConcept C2779227376 @default.
- W4386115003 hasConcept C2780020223 @default.
- W4386115003 hasConcept C2780035454 @default.
- W4386115003 hasConcept C2780401358 @default.
- W4386115003 hasConcept C43617362 @default.
- W4386115003 hasConcept C513153333 @default.
- W4386115003 hasConcept C521977710 @default.
- W4386115003 hasConcept C68928338 @default.
- W4386115003 hasConcept C71924100 @default.
- W4386115003 hasConcept C98274493 @default.
- W4386115003 hasConceptScore W4386115003C126322002 @default.
- W4386115003 hasConceptScore W4386115003C178790620 @default.
- W4386115003 hasConceptScore W4386115003C185592680 @default.
- W4386115003 hasConceptScore W4386115003C2776634624 @default.
- W4386115003 hasConceptScore W4386115003C2777317207 @default.
- W4386115003 hasConceptScore W4386115003C2778695967 @default.
- W4386115003 hasConceptScore W4386115003C2779227376 @default.
- W4386115003 hasConceptScore W4386115003C2780020223 @default.
- W4386115003 hasConceptScore W4386115003C2780035454 @default.
- W4386115003 hasConceptScore W4386115003C2780401358 @default.
- W4386115003 hasConceptScore W4386115003C43617362 @default.
- W4386115003 hasConceptScore W4386115003C513153333 @default.
- W4386115003 hasConceptScore W4386115003C521977710 @default.
- W4386115003 hasConceptScore W4386115003C68928338 @default.
- W4386115003 hasConceptScore W4386115003C71924100 @default.
- W4386115003 hasConceptScore W4386115003C98274493 @default.
- W4386115003 hasIssue "2" @default.
- W4386115003 hasLocation W43861150031 @default.
- W4386115003 hasLocation W43861150032 @default.
- W4386115003 hasOpenAccess W4386115003 @default.
- W4386115003 hasPrimaryLocation W43861150031 @default.
- W4386115003 hasRelatedWork W1586527361 @default.
- W4386115003 hasRelatedWork W2015197471 @default.
- W4386115003 hasRelatedWork W2077474882 @default.
- W4386115003 hasRelatedWork W2087241994 @default.
- W4386115003 hasRelatedWork W2098879162 @default.
- W4386115003 hasRelatedWork W2101059745 @default.
- W4386115003 hasRelatedWork W2161314874 @default.
- W4386115003 hasRelatedWork W2248335811 @default.
- W4386115003 hasRelatedWork W2379378259 @default.
- W4386115003 hasRelatedWork W3217388380 @default.
- W4386115003 hasVolume "3" @default.
- W4386115003 isParatext "false" @default.
- W4386115003 isRetracted "false" @default.
- W4386115003 workType "article" @default.