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- W4386116502 abstract "Transcytosis is an active transcellular transportation pathway that has garnered interest for overcoming the limited deep penetration of nanomedicines in solid tumors. In this study, a charge-convertible nanomedicine that facilitates deep penetration into solid tumors via transcytosis is designed. It is an albumin-based calcium phosphate nanomedicine loaded with IR820 (mAlb-820@CaP) for high-resolution photoacoustic imaging and enhanced photothermal therapy. Biomineralization on the surface stabilizes the albumin-IR820 complex during circulation and provides calcium ions (Ca2+ ) for tissue penetration on degradation in an acidic environment. pH-triggered transcytosis of the nanomedicine enabled by caveolae-mediated endocytosis and calcium ion-induced exocytosis in 2D cellular, 3D spheroid, and in vivo tumor models is demonstrated. Notably, the extravasation and penetration ability of the nanomedicine is observed in vivo using a high-resolution photoacoustic system, and nanomedicine shows the most potent photothermal antitumor effect in vivo. Overall, the strategy provides a versatile theragnosis platform for both noninvasive photoacoustic imaging and high therapeutic efficiency resulting from deep penetration of nanomedicine." @default.
- W4386116502 created "2023-08-25" @default.
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- W4386116502 date "2023-08-23" @default.
- W4386116502 modified "2023-10-14" @default.
- W4386116502 title "Transcytosis‐Inducing Multifunctional Albumin Nanomedicines with Deep Penetration Ability for Image‐Guided Solid Tumor Treatment" @default.
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- W4386116502 doi "https://doi.org/10.1002/smll.202303668" @default.
- W4386116502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37612796" @default.
- W4386116502 hasPublicationYear "2023" @default.
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