Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386118924> ?p ?o ?g. }
- W4386118924 abstract "Chemodynamic therapy (CDT) is a highly tumor-specific treatment, while its efficacy is compromised by the intratumoral Fenton reaction efficiency, which is determined by the following reaction factors, including the availability of Fenton ions (e.g., Fe2+), the amount of H2O2, and the degree of acidity. Synchronous optimization of these factors is a big challenge for efficient CDT. Herein, a strategy of comprehensively optimizing Fenton reaction factors was developed for traceable multistage augmented CDT by charge-reversal theranostics. The customized pH-responsive poly(ethylene)glycol-poly(β-amino esters) (PEG-PAE) micelle (PM) was prepared as the carrier. Glucose oxidase (GOx), Fe2+, and pH-responsive second near-infrared (NIR-II) LET-1052 probe were coloaded by PM to obtain the final theranostics. The activity of metastable Fe2+ remained by the unsaturated coordination with PEG-PAE. Then tumor accumulation and exposure of Fe2+ were achieved by charge-reversal cationization of PEG-PAE, which was further enhanced by a GOx catalysis-triggered pH decrease. Together with the abundant H2O2 generation and pH decrease through GOx catalysis, the limiting factors of the Fenton reaction were comprehensively optimized, achieving the enhanced CDT both in vitro and in vivo. These findings provide a strategy for comprehensively optimizing intratumoral Fenton reaction factors to overcome the intrinsic drawbacks of current CDT." @default.
- W4386118924 created "2023-08-25" @default.
- W4386118924 creator A5010302434 @default.
- W4386118924 creator A5042734796 @default.
- W4386118924 creator A5044797765 @default.
- W4386118924 creator A5051587991 @default.
- W4386118924 creator A5060049168 @default.
- W4386118924 creator A5062795464 @default.
- W4386118924 creator A5070015170 @default.
- W4386118924 creator A5071302603 @default.
- W4386118924 creator A5081037968 @default.
- W4386118924 date "2023-08-24" @default.
- W4386118924 modified "2023-10-14" @default.
- W4386118924 title "Comprehensively Optimizing Fenton Reaction Factors for Antitumor Chemodynamic Therapy by Charge-Reversal Theranostics" @default.
- W4386118924 cites W2002490399 @default.
- W4386118924 cites W2011434502 @default.
- W4386118924 cites W2189205651 @default.
- W4386118924 cites W2322655938 @default.
- W4386118924 cites W2425407891 @default.
- W4386118924 cites W2747423355 @default.
- W4386118924 cites W2766554468 @default.
- W4386118924 cites W2780522199 @default.
- W4386118924 cites W2884605745 @default.
- W4386118924 cites W2889392915 @default.
- W4386118924 cites W2898612072 @default.
- W4386118924 cites W2904585960 @default.
- W4386118924 cites W2905252880 @default.
- W4386118924 cites W2909064040 @default.
- W4386118924 cites W2941208104 @default.
- W4386118924 cites W2942343497 @default.
- W4386118924 cites W2943584912 @default.
- W4386118924 cites W2952499681 @default.
- W4386118924 cites W2954597343 @default.
- W4386118924 cites W2995423159 @default.
- W4386118924 cites W2996264612 @default.
- W4386118924 cites W3008745391 @default.
- W4386118924 cites W3016429694 @default.
- W4386118924 cites W3022794030 @default.
- W4386118924 cites W3027767846 @default.
- W4386118924 cites W3044116725 @default.
- W4386118924 cites W3092087927 @default.
- W4386118924 cites W3093021887 @default.
- W4386118924 cites W3100342993 @default.
- W4386118924 cites W3112947947 @default.
- W4386118924 cites W3125944921 @default.
- W4386118924 cites W3139346268 @default.
- W4386118924 cites W3154940127 @default.
- W4386118924 cites W3155774973 @default.
- W4386118924 cites W3155994067 @default.
- W4386118924 cites W3170716103 @default.
- W4386118924 cites W3173202432 @default.
- W4386118924 cites W3184063455 @default.
- W4386118924 cites W3201882315 @default.
- W4386118924 cites W3214413419 @default.
- W4386118924 cites W3217805896 @default.
- W4386118924 cites W4206273418 @default.
- W4386118924 cites W4213007988 @default.
- W4386118924 cites W4214686228 @default.
- W4386118924 cites W4220985978 @default.
- W4386118924 cites W4293175913 @default.
- W4386118924 cites W4295193267 @default.
- W4386118924 cites W4308294601 @default.
- W4386118924 cites W4313455277 @default.
- W4386118924 cites W4317106851 @default.
- W4386118924 cites W4317607576 @default.
- W4386118924 cites W4323073802 @default.
- W4386118924 doi "https://doi.org/10.1021/acsnano.3c03279" @default.
- W4386118924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37616516" @default.
- W4386118924 hasPublicationYear "2023" @default.
- W4386118924 type Work @default.
- W4386118924 citedByCount "0" @default.
- W4386118924 crossrefType "journal-article" @default.
- W4386118924 hasAuthorship W4386118924A5010302434 @default.
- W4386118924 hasAuthorship W4386118924A5042734796 @default.
- W4386118924 hasAuthorship W4386118924A5044797765 @default.
- W4386118924 hasAuthorship W4386118924A5051587991 @default.
- W4386118924 hasAuthorship W4386118924A5060049168 @default.
- W4386118924 hasAuthorship W4386118924A5062795464 @default.
- W4386118924 hasAuthorship W4386118924A5070015170 @default.
- W4386118924 hasAuthorship W4386118924A5071302603 @default.
- W4386118924 hasAuthorship W4386118924A5081037968 @default.
- W4386118924 hasConcept C10138342 @default.
- W4386118924 hasConcept C11268172 @default.
- W4386118924 hasConcept C127413603 @default.
- W4386118924 hasConcept C139066938 @default.
- W4386118924 hasConcept C161790260 @default.
- W4386118924 hasConcept C162324750 @default.
- W4386118924 hasConcept C171250308 @default.
- W4386118924 hasConcept C178790620 @default.
- W4386118924 hasConcept C181199279 @default.
- W4386118924 hasConcept C184651966 @default.
- W4386118924 hasConcept C185592680 @default.
- W4386118924 hasConcept C188198153 @default.
- W4386118924 hasConcept C192562407 @default.
- W4386118924 hasConcept C21951064 @default.
- W4386118924 hasConcept C2777197210 @default.
- W4386118924 hasConcept C2777516009 @default.
- W4386118924 hasConcept C2993040405 @default.
- W4386118924 hasConcept C54400483 @default.
- W4386118924 hasConcept C78519656 @default.