FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386123426> ?p ?o ?g. }

• W4386123426 endingPage "e5" @default.
• W4386123426 startingPage "e4" @default.
• W4386123426 abstract "Background/Synopsis Based on extensive clinical trial data demonstrating lower LDL-C reduces heart attacks, strokes, and need for interventional surgery, the 2018 Multidisciplinary Guideline on the Management of Blood Cholesterol calls for initiation and intensification of lipid-lowering therapies (LLT) if LDL-C exceeds defined thresholds in high and very high (H/VH) risk patients. Objective/Purpose Achievement of below-threshold LDL-C levels in H/VH risk patients was assessed using real-world data from the Family Heart Database (n=>324 million patients). Methods A subset of 38,110,734 guideline-defined, H/VH risk patients with sufficient diagnosis, procedure, medication, and lab data was analyzed. Patient histories were divided into contiguous episodes characterized by the LLT use (including none), prescription filling, and LDL-C level. Results Most H/VH risk patients (72%; n= 27,525,227) never achieved LDL-C below guideline thresholds. For those achieving periods below recommended LDL-C thresholds, mean duration was 159 days. Majority of HCPs (81%; n= 632,114) never prescribed combination LLT, though the guideline provides direction and rationale for doing so. Conclusions Despite effective and safe LLT, most H/VH patients remain above guideline-recommended LDL-C thresholds and those achieving persistent episodes below LDL-C thresholds do so for only brief durations. For the highest risk American patients, lack of prescribing combination LLT and low adherence to prescribed LLT fails to prevent future cardiovascular events. External Funding Yes Funding Sources The Family Heart Foundation is a 501c3 public charity research and advocacy organization that receives contributions and sponsorships from individuals, foundations, and pharmaceutical companies. This research was partially funded by Amgen, although it played no role in study design, conduct, interpretation or plans for publication. Based on extensive clinical trial data demonstrating lower LDL-C reduces heart attacks, strokes, and need for interventional surgery, the 2018 Multidisciplinary Guideline on the Management of Blood Cholesterol calls for initiation and intensification of lipid-lowering therapies (LLT) if LDL-C exceeds defined thresholds in high and very high (H/VH) risk patients. Achievement of below-threshold LDL-C levels in H/VH risk patients was assessed using real-world data from the Family Heart Database (n=>324 million patients). A subset of 38,110,734 guideline-defined, H/VH risk patients with sufficient diagnosis, procedure, medication, and lab data was analyzed. Patient histories were divided into contiguous episodes characterized by the LLT use (including none), prescription filling, and LDL-C level. Most H/VH risk patients (72%; n= 27,525,227) never achieved LDL-C below guideline thresholds. For those achieving periods below recommended LDL-C thresholds, mean duration was 159 days. Majority of HCPs (81%; n= 632,114) never prescribed combination LLT, though the guideline provides direction and rationale for doing so. Despite effective and safe LLT, most H/VH patients remain above guideline-recommended LDL-C thresholds and those achieving persistent episodes below LDL-C thresholds do so for only brief durations. For the highest risk American patients, lack of prescribing combination LLT and low adherence to prescribed LLT fails to prevent future cardiovascular events." @default.
• W4386123426 created "2023-08-25" @default.
• W4386123426 creator A5027488967 @default.
• W4386123426 creator A5033926723 @default.
• W4386123426 creator A5064400662 @default.
• W4386123426 creator A5066894991 @default.
• W4386123426 creator A5072641184 @default.
• W4386123426 date "2023-07-01" @default.
• W4386123426 modified "2023-09-25" @default.
• W4386123426 title "† The Vast Majority of High- and Very-High Risk Hypercholesterolemia Patients Never Reach below LDL-C Thresholds in the 2018 ACC/AHA Guidelines" @default.
• W4386123426 doi "https://doi.org/10.1016/j.jacl.2023.05.007" @default.
• W4386123426 hasPublicationYear "2023" @default.
• W4386123426 type Work @default.
• W4386123426 citedByCount "0" @default.
• W4386123426 crossrefType "journal-article" @default.
• W4386123426 hasAuthorship W4386123426A5027488967 @default.
• W4386123426 hasAuthorship W4386123426A5033926723 @default.
• W4386123426 hasAuthorship W4386123426A5064400662 @default.
• W4386123426 hasAuthorship W4386123426A5066894991 @default.
• W4386123426 hasAuthorship W4386123426A5072641184 @default.
• W4386123426 hasConcept C126322002 @default.
• W4386123426 hasConcept C142724271 @default.
• W4386123426 hasConcept C2426938 @default.
• W4386123426 hasConcept C2780182762 @default.
• W4386123426 hasConcept C535046627 @default.
• W4386123426 hasConcept C71924100 @default.
• W4386123426 hasConcept C98274493 @default.
• W4386123426 hasConceptScore W4386123426C126322002 @default.
• W4386123426 hasConceptScore W4386123426C142724271 @default.
• W4386123426 hasConceptScore W4386123426C2426938 @default.
• W4386123426 hasConceptScore W4386123426C2780182762 @default.
• W4386123426 hasConceptScore W4386123426C535046627 @default.
• W4386123426 hasConceptScore W4386123426C71924100 @default.
• W4386123426 hasConceptScore W4386123426C98274493 @default.
• W4386123426 hasIssue "4" @default.
• W4386123426 hasLocation W43861234261 @default.
• W4386123426 hasOpenAccess W4386123426 @default.
• W4386123426 hasPrimaryLocation W43861234261 @default.
• W4386123426 hasRelatedWork W1896195865 @default.
• W4386123426 hasRelatedWork W2022124951 @default.
• W4386123426 hasRelatedWork W2103375278 @default.
• W4386123426 hasRelatedWork W2141329339 @default.
• W4386123426 hasRelatedWork W2343552729 @default.
• W4386123426 hasRelatedWork W2388973478 @default.
• W4386123426 hasRelatedWork W2808068066 @default.
• W4386123426 hasRelatedWork W3192621155 @default.
• W4386123426 hasRelatedWork W4206351067 @default.
• W4386123426 hasRelatedWork W4249487090 @default.
• W4386123426 hasVolume "17" @default.
• W4386123426 isParatext "false" @default.
• W4386123426 isRetracted "false" @default.
• W4386123426 workType "article" @default.