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- W4386126080 abstract "Abstract Regulation of formate flux by a key folate enzyme, MTHFD2 (methylene tetrahydrofolate dehydrogenase 2) in cancer cells remains poorly understood. Green et al. (Nature Metabolism, 2023; 5: 642–659) showed an interesting phenomenon of “folate trapping” toxicity leads to cancer cell kill using a potent inhibitor (TH9619) against the dehydrogenase and cyclohydrolase (DC) activities of cytosolic methylenetetrahydrofolate dehydrogenase 1 (cMTHFD1) and nuclear methylenetetrahydrofolate dehydrogenase 2 (nMTHFD2), but not the mitochondrial MTHFD2 (mTHFD2). But, mMTHFD2 is required for formate flow to cytosol which leads to the trapping of 10‐formyl tetrahydrofolate and causes toxicity by TH9619 treatment, to kill cancer cells expressing mMTHFD2. This article opens new avenues to be evaluated for therapeutic benefits of cancer patients where MTHFD2 shows overexpression viz‐a‐viz breast, prostate, colorectal, acute myeloid leukemia, and other cancer types." @default.
- W4386126080 created "2023-08-25" @default.
- W4386126080 creator A5050022935 @default.
- W4386126080 date "2023-08-24" @default.
- W4386126080 modified "2023-09-27" @default.
- W4386126080 title "Folate trapping is lethal to cancer cells" @default.
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- W4386126080 doi "https://doi.org/10.1111/cbdd.14329" @default.
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