FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386127130> ?p ?o ?g. }

• W4386127130 abstract "Abstract Background Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photoreceptor degeneration are currently available in the clinical settings. It has been shown that hyperoside, a flavonol glycoside, protects against neuronal loss in part by suppressing oxidative stress and maintaining the functional integrity of mitochondria. However, whether hyperoside protects against photoreceptor degeneration remains unknown. Methods To address the pharmacological potentials of hyperoside against oxidative stress-mediated photoreceptor degeneration on molecular, cellular, structural and functional levels, multiple in vitro and in vivo methodologies were employed in the current study, including live-cell imaging, optical coherence tomography, electroretinography, histological/immunohistochemical examinations, transmission electron microscopy, RNA-sequencing and real-time qPCR. Results The in vitro results demonstrate that hyperoside suppresses oxidative stress-mediated photoreceptor cell death in part by mitigating mitochondrial dysfunction. The in vivo results reveal that hyperoside protects against photooxidative stress-induced photoreceptor morphological, functional and ultrastructural degeneration. Meanwhile, hyperoside treatment offsets the deleterious impact of photooxidative stress on multiple molecular pathways implicated in the pathogenesis of photoreceptor degeneration. Lastly, hyperoside attenuates photoreceptor degeneration-associated microglial inflammatory activation and reactive Müller cell gliosis. Conclusions All things considered, the present study demonstrates for the first time that hyperoside attenuates oxidative stress-induced photoreceptor mitochondrial dysfunction and cell death. The photoreceptor-intrinsic protective effects of hyperoside are corroborated by hyperoside-conferred protection against photooxidative stress-mediated photoreceptor degeneration and perturbation in retinal homeostasis, warranting further evaluation of hyperoside as a photoreceptor protective agent for the treatment of related photoreceptor degenerative diseases." @default.
• W4386127130 created "2023-08-25" @default.
• W4386127130 creator A5020160872 @default.
• W4386127130 creator A5022601974 @default.
• W4386127130 creator A5027410173 @default.
• W4386127130 creator A5028086701 @default.
• W4386127130 creator A5033068242 @default.
• W4386127130 creator A5033785543 @default.
• W4386127130 creator A5044807439 @default.
• W4386127130 creator A5049325403 @default.
• W4386127130 creator A5084281020 @default.
• W4386127130 creator A5085661189 @default.
• W4386127130 date "2023-08-24" @default.
• W4386127130 modified "2023-10-14" @default.
• W4386127130 title "Hyperoside protects against oxidative stress-mediated photoreceptor degeneration: therapeutic potentials for photoreceptor degenerative diseases" @default.
• W4386127130 cites W1618134065 @default.
• W4386127130 cites W1967081763 @default.
• W4386127130 cites W1970921442 @default.
• W4386127130 cites W1974113099 @default.
• W4386127130 cites W2024486785 @default.
• W4386127130 cites W2065028548 @default.
• W4386127130 cites W2077600892 @default.
• W4386127130 cites W2083572854 @default.
• W4386127130 cites W2096597598 @default.
• W4386127130 cites W2104612340 @default.
• W4386127130 cites W2131271579 @default.
• W4386127130 cites W2134526812 @default.
• W4386127130 cites W2141458291 @default.
• W4386127130 cites W2169108062 @default.
• W4386127130 cites W2625094533 @default.
• W4386127130 cites W2793623156 @default.
• W4386127130 cites W2906609084 @default.
• W4386127130 cites W2908296170 @default.
• W4386127130 cites W2965422920 @default.
• W4386127130 cites W2993468802 @default.
• W4386127130 cites W3009686570 @default.
• W4386127130 cites W3119952098 @default.
• W4386127130 cites W4200119598 @default.
• W4386127130 cites W4200150586 @default.
• W4386127130 cites W4200163705 @default.
• W4386127130 cites W4205817815 @default.
• W4386127130 cites W4224001709 @default.
• W4386127130 cites W4224938492 @default.
• W4386127130 cites W4232005894 @default.
• W4386127130 cites W4281606884 @default.
• W4386127130 cites W4285033060 @default.
• W4386127130 doi "https://doi.org/10.1186/s12967-023-04459-y" @default.
• W4386127130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37620913" @default.
• W4386127130 hasPublicationYear "2023" @default.
• W4386127130 type Work @default.
• W4386127130 citedByCount "0" @default.
• W4386127130 crossrefType "journal-article" @default.
• W4386127130 hasAuthorship W4386127130A5020160872 @default.
• W4386127130 hasAuthorship W4386127130A5022601974 @default.
• W4386127130 hasAuthorship W4386127130A5027410173 @default.
• W4386127130 hasAuthorship W4386127130A5028086701 @default.
• W4386127130 hasAuthorship W4386127130A5033068242 @default.
• W4386127130 hasAuthorship W4386127130A5033785543 @default.
• W4386127130 hasAuthorship W4386127130A5044807439 @default.
• W4386127130 hasAuthorship W4386127130A5049325403 @default.
• W4386127130 hasAuthorship W4386127130A5084281020 @default.
• W4386127130 hasAuthorship W4386127130A5085661189 @default.
• W4386127130 hasBestOaLocation W43861271301 @default.
• W4386127130 hasConcept C169760540 @default.
• W4386127130 hasConcept C190283241 @default.
• W4386127130 hasConcept C2775963812 @default.
• W4386127130 hasConcept C2776151105 @default.
• W4386127130 hasConcept C2776586676 @default.
• W4386127130 hasConcept C2777093970 @default.
• W4386127130 hasConcept C2778004101 @default.
• W4386127130 hasConcept C2780916184 @default.
• W4386127130 hasConcept C2781040256 @default.
• W4386127130 hasConcept C28859421 @default.
• W4386127130 hasConcept C31573885 @default.
• W4386127130 hasConcept C55493867 @default.
• W4386127130 hasConcept C86803240 @default.
• W4386127130 hasConcept C95444343 @default.
• W4386127130 hasConceptScore W4386127130C169760540 @default.
• W4386127130 hasConceptScore W4386127130C190283241 @default.
• W4386127130 hasConceptScore W4386127130C2775963812 @default.
• W4386127130 hasConceptScore W4386127130C2776151105 @default.
• W4386127130 hasConceptScore W4386127130C2776586676 @default.
• W4386127130 hasConceptScore W4386127130C2777093970 @default.
• W4386127130 hasConceptScore W4386127130C2778004101 @default.
• W4386127130 hasConceptScore W4386127130C2780916184 @default.
• W4386127130 hasConceptScore W4386127130C2781040256 @default.
• W4386127130 hasConceptScore W4386127130C28859421 @default.
• W4386127130 hasConceptScore W4386127130C31573885 @default.
• W4386127130 hasConceptScore W4386127130C55493867 @default.
• W4386127130 hasConceptScore W4386127130C86803240 @default.
• W4386127130 hasConceptScore W4386127130C95444343 @default.
• W4386127130 hasFunder F4320321001 @default.
• W4386127130 hasIssue "1" @default.
• W4386127130 hasLocation W43861271301 @default.
• W4386127130 hasLocation W43861271302 @default.
• W4386127130 hasOpenAccess W4386127130 @default.
• W4386127130 hasPrimaryLocation W43861271301 @default.
• W4386127130 hasRelatedWork W2015424171 @default.
• W4386127130 hasRelatedWork W2036667953 @default.
• W4386127130 hasRelatedWork W2044624385 @default.

• next