FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386127194> ?p ?o ?g. }

• W4386127194 endingPage "5445" @default.
• W4386127194 startingPage "5433" @default.
• W4386127194 abstract "Oxidative stress is the consequence of an abnormal increase of reactive oxygen species (ROS). ROS are generated mainly during the metabolism in both normal and pathological conditions as well as from exposure to xenobiotics. Xenobiotics can, on the one hand, disrupt molecular machinery involved in redox processes and, on the other hand, reduce the effectiveness of the antioxidant activity. Such dysregulation may lead to oxidative damage when combined with oxidative stress overpassing the cell capacity to detoxify ROS. In this work, a green fluorescent protein (GFP)-tagged nuclear factor erythroid 2-related factor 2 (NRF2)-regulated sulfiredoxin reporter (Srxn1-GFP) was used to measure the antioxidant response of HepG2 cells to a large series of drug and drug-like compounds (2230 compounds). These compounds were then classified as positive or negative depending on cellular response and distributed among different modeling groups to establish structure–activity relationship (SAR) models. A selection of models was used to prospectively predict oxidative stress induced by a new set of compounds subsequently experimentally tested to validate the model predictions. Altogether, this exercise exemplifies the different challenges of developing SAR models of a phenotypic cellular readout, model combination, chemical space selection, and results interpretation." @default.
• W4386127194 created "2023-08-25" @default.
• W4386127194 creator A5012413508 @default.
• W4386127194 creator A5028068407 @default.
• W4386127194 creator A5030705778 @default.
• W4386127194 creator A5057862489 @default.
• W4386127194 creator A5059420065 @default.
• W4386127194 creator A5060216077 @default.
• W4386127194 creator A5067014994 @default.
• W4386127194 creator A5072476426 @default.
• W4386127194 creator A5073657186 @default.
• W4386127194 creator A5076446637 @default.
• W4386127194 creator A5081295579 @default.
• W4386127194 creator A5088996741 @default.
• W4386127194 date "2023-08-24" @default.
• W4386127194 modified "2023-10-09" @default.
• W4386127194 title "Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells" @default.
• W4386127194 cites W1969268163 @default.
• W4386127194 cites W1979392432 @default.
• W4386127194 cites W1979900513 @default.
• W4386127194 cites W1988037271 @default.
• W4386127194 cites W1988790447 @default.
• W4386127194 cites W1992229282 @default.
• W4386127194 cites W2017912824 @default.
• W4386127194 cites W2018607502 @default.
• W4386127194 cites W2027037439 @default.
• W4386127194 cites W2066273100 @default.
• W4386127194 cites W2072624946 @default.
• W4386127194 cites W2074920600 @default.
• W4386127194 cites W2075118281 @default.
• W4386127194 cites W2075352120 @default.
• W4386127194 cites W2078880105 @default.
• W4386127194 cites W2097471815 @default.
• W4386127194 cites W2099536383 @default.
• W4386127194 cites W2100014056 @default.
• W4386127194 cites W2102548672 @default.
• W4386127194 cites W2102592852 @default.
• W4386127194 cites W2108285359 @default.
• W4386127194 cites W2109553965 @default.
• W4386127194 cites W2121469024 @default.
• W4386127194 cites W2121966499 @default.
• W4386127194 cites W2128992039 @default.
• W4386127194 cites W2146558971 @default.
• W4386127194 cites W2159887157 @default.
• W4386127194 cites W2165201727 @default.
• W4386127194 cites W2234887439 @default.
• W4386127194 cites W2425280153 @default.
• W4386127194 cites W2467412445 @default.
• W4386127194 cites W2550555349 @default.
• W4386127194 cites W2740946158 @default.
• W4386127194 cites W2766360556 @default.
• W4386127194 cites W2767891136 @default.
• W4386127194 cites W2791549452 @default.
• W4386127194 cites W2799986334 @default.
• W4386127194 cites W2802033104 @default.
• W4386127194 cites W2889276168 @default.
• W4386127194 cites W2910248242 @default.
• W4386127194 cites W2939321068 @default.
• W4386127194 cites W2998115089 @default.
• W4386127194 cites W3024267355 @default.
• W4386127194 cites W3024905693 @default.
• W4386127194 cites W3041734858 @default.
• W4386127194 cites W3082081167 @default.
• W4386127194 cites W3083058234 @default.
• W4386127194 cites W3134189711 @default.
• W4386127194 cites W3173289526 @default.
• W4386127194 cites W4200270278 @default.
• W4386127194 cites W4212883601 @default.
• W4386127194 cites W4236137412 @default.
• W4386127194 cites W4281658582 @default.
• W4386127194 cites W4283019934 @default.
• W4386127194 cites W4313816625 @default.
• W4386127194 cites W4317370024 @default.
• W4386127194 doi "https://doi.org/10.1021/acs.jcim.3c00220" @default.
• W4386127194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37616385" @default.
• W4386127194 hasPublicationYear "2023" @default.
• W4386127194 type Work @default.
• W4386127194 citedByCount "0" @default.
• W4386127194 crossrefType "journal-article" @default.
• W4386127194 hasAuthorship W4386127194A5012413508 @default.
• W4386127194 hasAuthorship W4386127194A5028068407 @default.
• W4386127194 hasAuthorship W4386127194A5030705778 @default.
• W4386127194 hasAuthorship W4386127194A5057862489 @default.
• W4386127194 hasAuthorship W4386127194A5059420065 @default.
• W4386127194 hasAuthorship W4386127194A5060216077 @default.
• W4386127194 hasAuthorship W4386127194A5067014994 @default.
• W4386127194 hasAuthorship W4386127194A5072476426 @default.
• W4386127194 hasAuthorship W4386127194A5073657186 @default.
• W4386127194 hasAuthorship W4386127194A5076446637 @default.
• W4386127194 hasAuthorship W4386127194A5081295579 @default.
• W4386127194 hasAuthorship W4386127194A5088996741 @default.
• W4386127194 hasBestOaLocation W43861271941 @default.
• W4386127194 hasConcept C104317684 @default.
• W4386127194 hasConcept C115448650 @default.
• W4386127194 hasConcept C12554922 @default.
• W4386127194 hasConcept C142613039 @default.
• W4386127194 hasConcept C181199279 @default.
• W4386127194 hasConcept C185592680 @default.

• next