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• W4386134844 abstract "Sickle cell disease (SCD) is the most common life-threatening monogenic disorder in the world. The disease is highly prevalent in malaria endemic areas with over 75% of patients residing in Sub-Saharan Africa (SSA). It is estimated that, without proper care, up to 90% of children with SCD will not celebrate their fifth birthday. Early identification and enrolment into comprehensive care has been shown to reduce the morbidity and mortality related with SCD complications. However, due to resource constraints, the SSA is yet to implement universal newborn screening programs for SCD. Furthermore, care for patients with SCD in the region is hampered by the shortage of qualified healthcare workers, lack of guidelines for the clinical management of SCD, limited infrastructure for inpatient and outpatient care, and limited access to blood and disease modifying drugs such as Hydroxyurea which contribute to poor clinical outcomes. Curative options such as bone marrow transplant and gene therapy are expensive and not available in many SSA countries. In addressing these challenges, various initiatives are ongoing in SSA which aim to enhance awareness on SCD, improve patient identification and retention to care, harmonize the standards of care for SCD, improve the skills of healthcare workers and conduct research on pertinent areas in SCD in the SSA context. Fortifying these measures is paramount to improving the outcomes of SCD in SSA." @default.
• W4386134844 created "2023-08-25" @default.
• W4386134844 creator A5014572143 @default.
• W4386134844 creator A5058586975 @default.
• W4386134844 date "2023-08-01" @default.
• W4386134844 modified "2023-09-27" @default.
• W4386134844 title "CURRENT CHALLENGES AND NEW APPROACHES TO IMPLEMENTING OPTIMAL MANAGEMENT OF SICKLE CELL DISEASE IN SUB-SAHARAN AFRICA" @default.
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