Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386136742> ?p ?o ?g. }
- W4386136742 abstract "Abstract The initial steps of B-cell acute lymphoblastic leukemia (B-ALL) development usually pass unnoticed in children. Several preclinical studies have shown that exposure to immune stressors triggers the transformation of preleukemic B cells to full-blown B-ALL, but how this takes place is still a longstanding and unsolved challenge. Here we show that dysregulation of innate immunity plays a driving role in the clonal evolution of pre-malignant Pax5 +/− B-cell precursors toward leukemia. Transcriptional profiling reveals that Myd88 is downregulated in immune-stressed pre-malignant B-cell precursors and in leukemic cells. Genetic reduction of Myd88 expression leads to a significant increase in leukemia incidence in Pax5 +/− Myd88 +/− mice through an inflammation-dependent mechanism. Early induction of Myd88-independent Toll-like receptor 3 signaling results in a significant delay of leukemia development in Pax5 +/− mice. Altogether, these findings identify a role for innate immunity dysregulation in leukemia, with important implications for understanding and therapeutic targeting of the preleukemic state in children." @default.
- W4386136742 created "2023-08-25" @default.
- W4386136742 creator A5002157798 @default.
- W4386136742 creator A5009736782 @default.
- W4386136742 creator A5011999361 @default.
- W4386136742 creator A5013708643 @default.
- W4386136742 creator A5017625141 @default.
- W4386136742 creator A5019388965 @default.
- W4386136742 creator A5025442855 @default.
- W4386136742 creator A5027525612 @default.
- W4386136742 creator A5033002324 @default.
- W4386136742 creator A5033492560 @default.
- W4386136742 creator A5034985610 @default.
- W4386136742 creator A5043206211 @default.
- W4386136742 creator A5049312995 @default.
- W4386136742 creator A5053268426 @default.
- W4386136742 creator A5056817439 @default.
- W4386136742 creator A5059820543 @default.
- W4386136742 creator A5064577465 @default.
- W4386136742 creator A5065657518 @default.
- W4386136742 creator A5068635814 @default.
- W4386136742 creator A5068819185 @default.
- W4386136742 creator A5075974674 @default.
- W4386136742 creator A5088409474 @default.
- W4386136742 creator A5090598948 @default.
- W4386136742 date "2023-08-24" @default.
- W4386136742 modified "2023-10-18" @default.
- W4386136742 title "Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice" @default.
- W4386136742 cites W184470020 @default.
- W4386136742 cites W1948212455 @default.
- W4386136742 cites W1969041059 @default.
- W4386136742 cites W1973389174 @default.
- W4386136742 cites W1990145497 @default.
- W4386136742 cites W1993648538 @default.
- W4386136742 cites W2017318696 @default.
- W4386136742 cites W2020541351 @default.
- W4386136742 cites W2023106264 @default.
- W4386136742 cites W2028601867 @default.
- W4386136742 cites W2031611770 @default.
- W4386136742 cites W2035502959 @default.
- W4386136742 cites W2041053955 @default.
- W4386136742 cites W2059356728 @default.
- W4386136742 cites W2070597700 @default.
- W4386136742 cites W2076361525 @default.
- W4386136742 cites W2077749593 @default.
- W4386136742 cites W2089478119 @default.
- W4386136742 cites W2103441770 @default.
- W4386136742 cites W2103456856 @default.
- W4386136742 cites W2111350087 @default.
- W4386136742 cites W2114358266 @default.
- W4386136742 cites W2122514887 @default.
- W4386136742 cites W2123106337 @default.
- W4386136742 cites W2123459977 @default.
- W4386136742 cites W2127774996 @default.
- W4386136742 cites W2130410032 @default.
- W4386136742 cites W2130807641 @default.
- W4386136742 cites W2130981421 @default.
- W4386136742 cites W2132109848 @default.
- W4386136742 cites W2133856765 @default.
- W4386136742 cites W2138601221 @default.
- W4386136742 cites W2140946267 @default.
- W4386136742 cites W2145664556 @default.
- W4386136742 cites W2146005104 @default.
- W4386136742 cites W2147618390 @default.
- W4386136742 cites W2151645052 @default.
- W4386136742 cites W2151794156 @default.
- W4386136742 cites W2152956782 @default.
- W4386136742 cites W2154026962 @default.
- W4386136742 cites W2155943701 @default.
- W4386136742 cites W2156491752 @default.
- W4386136742 cites W2163465586 @default.
- W4386136742 cites W2166655850 @default.
- W4386136742 cites W2170024099 @default.
- W4386136742 cites W2170222864 @default.
- W4386136742 cites W2178468712 @default.
- W4386136742 cites W2214074259 @default.
- W4386136742 cites W2235737683 @default.
- W4386136742 cites W2337209831 @default.
- W4386136742 cites W2400297147 @default.
- W4386136742 cites W2401404581 @default.
- W4386136742 cites W2513185582 @default.
- W4386136742 cites W2582800429 @default.
- W4386136742 cites W2607969054 @default.
- W4386136742 cites W2625969065 @default.
- W4386136742 cites W2790670900 @default.
- W4386136742 cites W2804265396 @default.
- W4386136742 cites W2805756787 @default.
- W4386136742 cites W2807194798 @default.
- W4386136742 cites W2867868648 @default.
- W4386136742 cites W2919370328 @default.
- W4386136742 cites W2951874439 @default.
- W4386136742 cites W2963276645 @default.
- W4386136742 cites W2971999614 @default.
- W4386136742 cites W2991676973 @default.
- W4386136742 cites W3009961339 @default.
- W4386136742 cites W3086420584 @default.
- W4386136742 cites W3091873738 @default.
- W4386136742 cites W3126489593 @default.
- W4386136742 cites W3147292950 @default.
- W4386136742 cites W4221097431 @default.