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- W4386136957 abstract "While blood clot formation has been relatively well studied, little is known about the mechanisms underlying the subsequent structural and mechanical clot remodeling called contraction or retraction. Impairment of the clot contraction process is associated with both life-threatening bleeding and thrombotic conditions, such as ischemic stroke, venous thromboembolism, and others. Recently, blood clot contraction was observed to be hindered in patients with COVID-19. A three-dimensional multiscale computational model is developed and used to quantify biomechanical mechanisms of the kinetics of clot contraction driven by platelet-fibrin pulling interactions. These results provide important biological insights into contraction of platelet filopodia, the mechanically active thin protrusions of the plasma membrane, described previously as performing mostly a sensory function. The biomechanical mechanisms and modeling approach described can potentially apply to studying other systems in which cells are embedded in a filamentous network and exert forces on the extracellular matrix modulated by the substrate stiffness." @default.
- W4386136957 created "2023-08-25" @default.
- W4386136957 creator A5000234159 @default.
- W4386136957 creator A5000747347 @default.
- W4386136957 creator A5001017638 @default.
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- W4386136957 creator A5018163768 @default.
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- W4386136957 creator A5080240010 @default.
- W4386136957 creator A5084556113 @default.
- W4386136957 creator A5089911552 @default.
- W4386136957 date "2023-08-24" @default.
- W4386136957 modified "2023-10-18" @default.
- W4386136957 title "Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots" @default.
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