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- W4386141158 abstract "Many experiments showed that eukaryotic cells maintain a constant mRNA concentration upon various perturbations by actively regulating mRNA production and degradation rates, known as mRNA buffering. However, the underlying mechanism is still unknown. Here, we propose a mechanistic model of mRNA buffering: the releasing-shuttling (RS) model. The model incorporates two crucial factors, X and Y, which play significant roles in the transcription, exportation, and degradation processes. The model explains the constant mRNA concentration under genome-wide genetic perturbations and cell volume changes. Moreover, it quantitatively explains the slowed-down mRNA degradation after Pol II depletion and the temporal transcription dynamics after Xrn1 depletion. The RS model suggests that X and Y are likely composed of multiple molecules possessing redundant functions. We also present a list of potential X and Y candidates and an experimental method to identify X. Our work sheds light on a novel coupling mechanism between mRNA production, exportation, and degradation." @default.
- W4386141158 created "2023-08-25" @default.
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- W4386141158 date "2023-08-23" @default.
- W4386141158 modified "2023-10-14" @default.
- W4386141158 title "Searching the mechanisms of mRNA buffering: the releasing-shuttling model" @default.
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- W4386141158 doi "https://doi.org/10.1101/2023.08.23.554439" @default.
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