Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386141520> ?p ?o ?g. }
- W4386141520 endingPage "13143" @default.
- W4386141520 startingPage "13143" @default.
- W4386141520 abstract "Epilepsy is a multifactorial neurologic disease that often leads to many devastating disabilities and an enormous burden on the healthcare system. Until now, drug-resistant epilepsy has presented a major challenge for approximately 30% of the epileptic population. The present article summarizes the validated rodent models of seizures employed in pharmacological researches and comprehensively reviews updated advances of novel antiseizure candidates in the preclinical phase. Newly discovered compounds that demonstrate antiseizure efficacy in preclinical trials will be discussed in the review. It is inspiring that several candidates exert promising antiseizure activities in drug-resistant seizure models. The representative compounds consist of derivatives of hybrid compounds that integrate multiple approved antiseizure medications, novel positive allosteric modulators targeting subtype-selective γ-Aminobutyric acid type A receptors, and a derivative of cinnamamide. Although the precise molecular mechanism, pharmacokinetic properties, and safety are not yet fully clear in every novel antiseizure candidate, the adapted approaches to design novel antiseizure medications provide new insights to overcome drug-resistant epilepsy." @default.
- W4386141520 created "2023-08-25" @default.
- W4386141520 creator A5001311279 @default.
- W4386141520 creator A5001882016 @default.
- W4386141520 creator A5016069333 @default.
- W4386141520 creator A5023214268 @default.
- W4386141520 creator A5027912422 @default.
- W4386141520 date "2023-08-24" @default.
- W4386141520 modified "2023-09-27" @default.
- W4386141520 title "Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies" @default.
- W4386141520 cites W1574241265 @default.
- W4386141520 cites W1590926633 @default.
- W4386141520 cites W1607402462 @default.
- W4386141520 cites W1875008998 @default.
- W4386141520 cites W1965016243 @default.
- W4386141520 cites W1968259409 @default.
- W4386141520 cites W1972894928 @default.
- W4386141520 cites W1974809694 @default.
- W4386141520 cites W1976206458 @default.
- W4386141520 cites W1979315780 @default.
- W4386141520 cites W1981853766 @default.
- W4386141520 cites W1987398739 @default.
- W4386141520 cites W1996258496 @default.
- W4386141520 cites W2000306331 @default.
- W4386141520 cites W200114720 @default.
- W4386141520 cites W2002706201 @default.
- W4386141520 cites W2006516773 @default.
- W4386141520 cites W2008424047 @default.
- W4386141520 cites W2013413818 @default.
- W4386141520 cites W2016045691 @default.
- W4386141520 cites W2016871340 @default.
- W4386141520 cites W2017398416 @default.
- W4386141520 cites W2019884656 @default.
- W4386141520 cites W2020062958 @default.
- W4386141520 cites W2022919161 @default.
- W4386141520 cites W2031483215 @default.
- W4386141520 cites W2035592411 @default.
- W4386141520 cites W2036278822 @default.
- W4386141520 cites W2037997999 @default.
- W4386141520 cites W2041317342 @default.
- W4386141520 cites W2042706869 @default.
- W4386141520 cites W2043053592 @default.
- W4386141520 cites W2044857503 @default.
- W4386141520 cites W2045025689 @default.
- W4386141520 cites W2056461128 @default.
- W4386141520 cites W2059029728 @default.
- W4386141520 cites W2061678383 @default.
- W4386141520 cites W2065253872 @default.
- W4386141520 cites W2068692832 @default.
- W4386141520 cites W2070510853 @default.
- W4386141520 cites W2077005987 @default.
- W4386141520 cites W2081414985 @default.
- W4386141520 cites W2084708682 @default.
- W4386141520 cites W2085681646 @default.
- W4386141520 cites W2100283245 @default.
- W4386141520 cites W2103946141 @default.
- W4386141520 cites W2106277748 @default.
- W4386141520 cites W2113211592 @default.
- W4386141520 cites W2126829625 @default.
- W4386141520 cites W2127296441 @default.
- W4386141520 cites W2130081367 @default.
- W4386141520 cites W2136736468 @default.
- W4386141520 cites W2141557104 @default.
- W4386141520 cites W2146793066 @default.
- W4386141520 cites W2155633484 @default.
- W4386141520 cites W2164573587 @default.
- W4386141520 cites W2305813206 @default.
- W4386141520 cites W2314551501 @default.
- W4386141520 cites W2316059958 @default.
- W4386141520 cites W2346585656 @default.
- W4386141520 cites W2401188729 @default.
- W4386141520 cites W2425862959 @default.
- W4386141520 cites W2473710724 @default.
- W4386141520 cites W2476169670 @default.
- W4386141520 cites W2476259579 @default.
- W4386141520 cites W2477963580 @default.
- W4386141520 cites W2559901472 @default.
- W4386141520 cites W2573551545 @default.
- W4386141520 cites W2586586421 @default.
- W4386141520 cites W2610210587 @default.
- W4386141520 cites W2726666234 @default.
- W4386141520 cites W2736135437 @default.
- W4386141520 cites W2741416474 @default.
- W4386141520 cites W2756787487 @default.
- W4386141520 cites W2763452490 @default.
- W4386141520 cites W2786898826 @default.
- W4386141520 cites W2791893982 @default.
- W4386141520 cites W2794791794 @default.
- W4386141520 cites W2794946189 @default.
- W4386141520 cites W2796117823 @default.
- W4386141520 cites W2801031269 @default.
- W4386141520 cites W2890765873 @default.
- W4386141520 cites W2892906275 @default.
- W4386141520 cites W2901763507 @default.
- W4386141520 cites W2903820216 @default.
- W4386141520 cites W2912477090 @default.
- W4386141520 cites W2950862045 @default.
- W4386141520 cites W2954314772 @default.