FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386143154> ?p ?o ?g. }

• W4386143154 endingPage "42" @default.
• W4386143154 startingPage "33" @default.
• W4386143154 abstract "Diabetic foot (DF) is one of the serious chronic complications of diabetes. Accurate prediction of the risk of DF may take timely intervention measures to prevent its occurrence. The understanding of metabolomic changes in the progression of diabetes to DF may reveal new targets for interventions. We hypothesized that changes in metabolic pathways during DF would lead to changes in the metabolic profile, which could be predictive signature specific to it. In the present study, 43 participants with type 2 diabetes mellitus (T2DM), 32 T2DM participants with DF (T2DM-F), and 36 healthy subjects were enrolled and their serum samples were used for targeted and nonpolar metabolic analysis with liquid chromatography-tandem mass spectrometry. Differential metabolites related to T2DM-F were discovered in metabolomic analysis. Lasso machine learning regression model, random forest algorithm, causal mediation analysis, disease risk assessment, and clinical decision model were carried out. T2DM and T2DM-F groups could be distinguished with the healthy control group. The differential metabolites were all enriched in alpha-linolenic acid and linoleic acid metabolic pathways including arachidonic acid, docosapentaenoic-acid 22N-6, and docosahexaenoic-acid, which were significantly lower in the T2DM and T2DM-F groups compared with the healthy control group. The differential metabolites in T2DM-F vs T2DM groups were enriched to branched-chain amino acid (BCAA) catabolic pathways involving in methylmalonic acid, succinic acid, 3-methyl-2-oxovaleric acid, and ketoleucine, which were the BCAA catabolic intermediates and significantly lower in the T2DM-F compared with the T2DM group except for succinic acid. We reveal a new set of predictive signatures and associate the lower BCAA catabolic intermediates with the progression from T2DM to T2DM-F." @default.
• W4386143154 created "2023-08-25" @default.
• W4386143154 creator A5024854248 @default.
• W4386143154 creator A5042140487 @default.
• W4386143154 creator A5062740680 @default.
• W4386143154 creator A5063481044 @default.
• W4386143154 creator A5064564309 @default.
• W4386143154 creator A5083097968 @default.
• W4386143154 creator A5089438704 @default.
• W4386143154 creator A5091328279 @default.
• W4386143154 date "2023-11-01" @default.
• W4386143154 modified "2023-09-26" @default.
• W4386143154 title "Lower serum branched-chain amino acid catabolic intermediates are predictive signatures specific to diabetic foot patients" @default.
• W4386143154 cites W153902777 @default.
• W4386143154 cites W2002364623 @default.
• W4386143154 cites W2010813622 @default.
• W4386143154 cites W2031742114 @default.
• W4386143154 cites W2036171282 @default.
• W4386143154 cites W2093036594 @default.
• W4386143154 cites W2467737848 @default.
• W4386143154 cites W2626354203 @default.
• W4386143154 cites W2791925845 @default.
• W4386143154 cites W2885375855 @default.
• W4386143154 cites W2897779004 @default.
• W4386143154 cites W2900077271 @default.
• W4386143154 cites W2902246840 @default.
• W4386143154 cites W2916468376 @default.
• W4386143154 cites W2945582641 @default.
• W4386143154 cites W2972532878 @default.
• W4386143154 cites W2972869264 @default.
• W4386143154 cites W3027203282 @default.
• W4386143154 cites W3108313162 @default.
• W4386143154 cites W3109562461 @default.
• W4386143154 cites W3114106541 @default.
• W4386143154 cites W3123047394 @default.
• W4386143154 cites W3163042872 @default.
• W4386143154 cites W3165338098 @default.
• W4386143154 cites W3198534630 @default.
• W4386143154 cites W3207456244 @default.
• W4386143154 cites W4213305436 @default.
• W4386143154 cites W4280496046 @default.
• W4386143154 cites W4289861187 @default.
• W4386143154 cites W4293748996 @default.
• W4386143154 doi "https://doi.org/10.1016/j.nutres.2023.08.009" @default.
• W4386143154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37716292" @default.
• W4386143154 hasPublicationYear "2023" @default.
• W4386143154 type Work @default.
• W4386143154 citedByCount "0" @default.
• W4386143154 crossrefType "journal-article" @default.
• W4386143154 hasAuthorship W4386143154A5024854248 @default.
• W4386143154 hasAuthorship W4386143154A5042140487 @default.
• W4386143154 hasAuthorship W4386143154A5062740680 @default.
• W4386143154 hasAuthorship W4386143154A5063481044 @default.
• W4386143154 hasAuthorship W4386143154A5064564309 @default.
• W4386143154 hasAuthorship W4386143154A5083097968 @default.
• W4386143154 hasAuthorship W4386143154A5089438704 @default.
• W4386143154 hasAuthorship W4386143154A5091328279 @default.
• W4386143154 hasConcept C126322002 @default.
• W4386143154 hasConcept C134018914 @default.
• W4386143154 hasConcept C19038510 @default.
• W4386143154 hasConcept C21565614 @default.
• W4386143154 hasConcept C2777171753 @default.
• W4386143154 hasConcept C2777180221 @default.
• W4386143154 hasConcept C2780809830 @default.
• W4386143154 hasConcept C2781349093 @default.
• W4386143154 hasConcept C2910068830 @default.
• W4386143154 hasConcept C543025807 @default.
• W4386143154 hasConcept C55493867 @default.
• W4386143154 hasConcept C555293320 @default.
• W4386143154 hasConcept C60644358 @default.
• W4386143154 hasConcept C62231903 @default.
• W4386143154 hasConcept C71924100 @default.
• W4386143154 hasConcept C86803240 @default.
• W4386143154 hasConcept C96942376 @default.
• W4386143154 hasConceptScore W4386143154C126322002 @default.
• W4386143154 hasConceptScore W4386143154C134018914 @default.
• W4386143154 hasConceptScore W4386143154C19038510 @default.
• W4386143154 hasConceptScore W4386143154C21565614 @default.
• W4386143154 hasConceptScore W4386143154C2777171753 @default.
• W4386143154 hasConceptScore W4386143154C2777180221 @default.
• W4386143154 hasConceptScore W4386143154C2780809830 @default.
• W4386143154 hasConceptScore W4386143154C2781349093 @default.
• W4386143154 hasConceptScore W4386143154C2910068830 @default.
• W4386143154 hasConceptScore W4386143154C543025807 @default.
• W4386143154 hasConceptScore W4386143154C55493867 @default.
• W4386143154 hasConceptScore W4386143154C555293320 @default.
• W4386143154 hasConceptScore W4386143154C60644358 @default.
• W4386143154 hasConceptScore W4386143154C62231903 @default.
• W4386143154 hasConceptScore W4386143154C71924100 @default.
• W4386143154 hasConceptScore W4386143154C86803240 @default.
• W4386143154 hasConceptScore W4386143154C96942376 @default.
• W4386143154 hasFunder F4320326705 @default.
• W4386143154 hasFunder F4320335767 @default.
• W4386143154 hasLocation W43861431541 @default.
• W4386143154 hasLocation W43861431542 @default.
• W4386143154 hasOpenAccess W4386143154 @default.
• W4386143154 hasPrimaryLocation W43861431541 @default.
• W4386143154 hasRelatedWork W2046565250 @default.

• next