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- W4386143521 abstract "Oxylipins are important signalling compounds that are significantly involved in the regulation of the immune system and the resolution of inflammation. Lipid metabolism is strongly activated upon SARS-CoV-2 infection, however the modulating effects of oxylipins induced by different variants remain unexplored. Here, we compare the plasma profiles of thirty-seven oxylipins and four PUFAs in subjects infected with Wild-type, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variants. The results suggest that oxidative stress and inflammation resulting from COVID-19 were highly dependent on the SARS-CoV-2 variant, and that the Wild-type elicited the strongest inflammatory storm. The Alpha and Delta variants induced a comparable lipid profile alteration upon infection, which differed significantly from Omicron. The latter variant increased the levels of pro-inflammatory mediators and decreased the levels of omega-3 PUFA in infected patients. We speculate that changes in therapeutics, vaccination, and prior infections may have a role in the alteration of the oxylipin profile besides viral mutations. The results shed new light on the evolution of the inflammatory response in COVID-19." @default.
- W4386143521 created "2023-08-25" @default.
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- W4386143521 date "2023-12-01" @default.
- W4386143521 modified "2023-09-23" @default.
- W4386143521 title "The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients" @default.
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- W4386143521 doi "https://doi.org/10.1016/j.prostaglandins.2023.106770" @default.
- W4386143521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37633481" @default.
- W4386143521 hasPublicationYear "2023" @default.
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