FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386150907> ?p ?o ?g. }

• W4386150907 abstract "In liquid water, there is a natural tendency to form aggregates that consist of water molecules linked by hydrogen bonds. Such spontaneously formed aggregates are surrounded by a “sea” of disordered water molecules, with both forms remaining in equilibrium. The process of creating water aggregates also takes place in the solvation water of proteins, but in this case, the interactions of water molecules with the protein surface shift the equilibrium of the process. In this paper, we analyze the structural properties of the solvation water in antifreeze proteins (AFPs). The results of molecular dynamics analysis with the use of various parameters related to the structure of solvation water on the protein surface are presented. We found that in the vicinity of the active region responsible for the binding of AFPs to ice, the equilibrium is clearly shifted toward the formation of “ice-like aggregates,” and the solvation water has a more ordered ice-like structure. We have demonstrated that a reduction in the tendency to create “ice-like aggregates” results in a significant reduction in the antifreeze activity of the protein. We conclude that shifting the equilibrium in favor of the formation of “ice-like aggregates” in the solvation water in the active region is a prerequisite for the biological functionality of AFPs, at least for AFPs having a well-defined ice binding area. In addition, our results fully confirm the validity of the “anchored clathrate water” concept, formulated by Garnham et al. [Proc. Natl. Acad. Sci. U. S. A. 108, 7363 (2011)]." @default.
• W4386150907 created "2023-08-26" @default.
• W4386150907 creator A5015851728 @default.
• W4386150907 date "2023-08-25" @default.
• W4386150907 modified "2023-10-17" @default.
• W4386150907 title "Mechanism of antifreeze protein functioning and the “anchored clathrate water” concept" @default.
• W4386150907 cites W1537479324 @default.
• W4386150907 cites W1555425311 @default.
• W4386150907 cites W1967421731 @default.
• W4386150907 cites W1978504918 @default.
• W4386150907 cites W1979275471 @default.
• W4386150907 cites W1990791101 @default.
• W4386150907 cites W1992210899 @default.
• W4386150907 cites W1994643710 @default.
• W4386150907 cites W1997032299 @default.
• W4386150907 cites W2000402055 @default.
• W4386150907 cites W2002555240 @default.
• W4386150907 cites W2004520885 @default.
• W4386150907 cites W2004765394 @default.
• W4386150907 cites W2005294752 @default.
• W4386150907 cites W2007040094 @default.
• W4386150907 cites W2007331423 @default.
• W4386150907 cites W2014563681 @default.
• W4386150907 cites W2015520136 @default.
• W4386150907 cites W2016295920 @default.
• W4386150907 cites W2023599699 @default.
• W4386150907 cites W2023657602 @default.
• W4386150907 cites W2026351476 @default.
• W4386150907 cites W2028662950 @default.
• W4386150907 cites W2030142321 @default.
• W4386150907 cites W2030479202 @default.
• W4386150907 cites W2035266068 @default.
• W4386150907 cites W2037457260 @default.
• W4386150907 cites W2041787703 @default.
• W4386150907 cites W2042571234 @default.
• W4386150907 cites W2043512464 @default.
• W4386150907 cites W2057500869 @default.
• W4386150907 cites W2064235624 @default.
• W4386150907 cites W2068281039 @default.
• W4386150907 cites W2074117796 @default.
• W4386150907 cites W2076194504 @default.
• W4386150907 cites W2076438512 @default.
• W4386150907 cites W2083735976 @default.
• W4386150907 cites W2090026561 @default.
• W4386150907 cites W2092943027 @default.
• W4386150907 cites W2109532360 @default.
• W4386150907 cites W2117957872 @default.
• W4386150907 cites W2120571418 @default.
• W4386150907 cites W2135448686 @default.
• W4386150907 cites W2137247608 @default.
• W4386150907 cites W2139511716 @default.
• W4386150907 cites W2168553155 @default.
• W4386150907 cites W2168610125 @default.
• W4386150907 cites W2168629258 @default.
• W4386150907 cites W2314532442 @default.
• W4386150907 cites W2319469731 @default.
• W4386150907 cites W2408864898 @default.
• W4386150907 cites W2684267623 @default.
• W4386150907 cites W2792049678 @default.
• W4386150907 cites W2820141969 @default.
• W4386150907 cites W2894270242 @default.
• W4386150907 cites W2905424662 @default.
• W4386150907 cites W2927437806 @default.
• W4386150907 cites W2969107345 @default.
• W4386150907 cites W3007789978 @default.
• W4386150907 cites W3011818270 @default.
• W4386150907 cites W3110432789 @default.
• W4386150907 cites W3126890499 @default.
• W4386150907 cites W3209646263 @default.
• W4386150907 cites W4221066422 @default.
• W4386150907 cites W4238642012 @default.
• W4386150907 cites W4293109355 @default.
• W4386150907 doi "https://doi.org/10.1063/5.0158590" @default.
• W4386150907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37622597" @default.
• W4386150907 hasPublicationYear "2023" @default.
• W4386150907 type Work @default.
• W4386150907 citedByCount "0" @default.
• W4386150907 crossrefType "journal-article" @default.
• W4386150907 hasAuthorship W4386150907A5015851728 @default.
• W4386150907 hasBestOaLocation W43861509071 @default.
• W4386150907 hasConcept C100402318 @default.
• W4386150907 hasConcept C112887158 @default.
• W4386150907 hasConcept C121332964 @default.
• W4386150907 hasConcept C1276947 @default.
• W4386150907 hasConcept C141734981 @default.
• W4386150907 hasConcept C147597530 @default.
• W4386150907 hasConcept C148093993 @default.
• W4386150907 hasConcept C149823470 @default.
• W4386150907 hasConcept C159467904 @default.
• W4386150907 hasConcept C178790620 @default.
• W4386150907 hasConcept C185592680 @default.
• W4386150907 hasConcept C2778802280 @default.
• W4386150907 hasConcept C2781060337 @default.
• W4386150907 hasConcept C29705727 @default.
• W4386150907 hasConcept C32909587 @default.
• W4386150907 hasConcept C55493867 @default.
• W4386150907 hasConcept C59593255 @default.
• W4386150907 hasConceptScore W4386150907C100402318 @default.
• W4386150907 hasConceptScore W4386150907C112887158 @default.
• W4386150907 hasConceptScore W4386150907C121332964 @default.

• next