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- W4386151686 abstract "Short-chain fatty acids (SCFAs) are biosynthesized via fermentation of polysaccharides by gastrointestinal microbiota and have been shown to have wide-reaching effects on almost all tissues, including the pancreatic islets. Historically, the effects of SCFAs have been attributed to their intracellular metabolism and function as energy sources, but the discovery of free fatty acid G protein-coupled receptors (GPCRs) in the 2000s suggested that many functional outcomes of SCFAs are receptor-mediated. The SCFA receptors FFA2/GPR43 and FFA3/GPR41 are expressed on β-cells, where they regulate glucose-dependent insulin secretion, making them attractive targets for treatment of diabetes and other metabolic disorders. Here, we provide an update on the current evidence regarding regulation of FFA2/FFA3 receptors by specific probiotic bacterial species within the gut microbiome that synthesize SCFAs. We also review the body of research regarding the FFA2- and FFA3 receptor-specific function of SCFAs on β-cells and discuss the somewhat controversial and opposing findings within these studies." @default.
- W4386151686 created "2023-08-26" @default.
- W4386151686 creator A5035095118 @default.
- W4386151686 creator A5092692527 @default.
- W4386151686 date "2023-09-28" @default.
- W4386151686 modified "2023-09-30" @default.
- W4386151686 title "Gut feelings in the islets: the role of the gut microbiome and the SCFA receptors FFA2/FFA3 on β‐cell function and metabolic regulation" @default.
- W4386151686 cites W1458931011 @default.
- W4386151686 cites W1886288445 @default.
- W4386151686 cites W1953702613 @default.
- W4386151686 cites W1972691065 @default.
- W4386151686 cites W1981604468 @default.
- W4386151686 cites W1990590570 @default.
- W4386151686 cites W1991006409 @default.
- W4386151686 cites W1994863439 @default.
- W4386151686 cites W2001105216 @default.
- W4386151686 cites W2001938165 @default.
- W4386151686 cites W2009170813 @default.
- W4386151686 cites W2031069848 @default.
- W4386151686 cites W2035421462 @default.
- W4386151686 cites W2037404289 @default.
- W4386151686 cites W2037921130 @default.
- W4386151686 cites W2046315492 @default.
- W4386151686 cites W2048930008 @default.
- W4386151686 cites W2069395441 @default.
- W4386151686 cites W2078455937 @default.
- W4386151686 cites W2080842149 @default.
- W4386151686 cites W2098863183 @default.
- W4386151686 cites W2108878645 @default.
- W4386151686 cites W2110936821 @default.
- W4386151686 cites W2114905099 @default.
- W4386151686 cites W2125826054 @default.
- W4386151686 cites W2126295648 @default.
- W4386151686 cites W2132033020 @default.
- W4386151686 cites W2133487229 @default.
- W4386151686 cites W2134066378 @default.
- W4386151686 cites W2137900887 @default.
- W4386151686 cites W2140663833 @default.
- W4386151686 cites W2142228286 @default.
- W4386151686 cites W2142336938 @default.
- W4386151686 cites W2144754352 @default.
- W4386151686 cites W2155658630 @default.
- W4386151686 cites W2162704444 @default.
- W4386151686 cites W2163878401 @default.
- W4386151686 cites W2167062509 @default.
- W4386151686 cites W2168842536 @default.
- W4386151686 cites W2177556732 @default.
- W4386151686 cites W2182287566 @default.
- W4386151686 cites W2209556632 @default.
- W4386151686 cites W2236332835 @default.
- W4386151686 cites W2278139579 @default.
- W4386151686 cites W2279049687 @default.
- W4386151686 cites W2396693700 @default.
- W4386151686 cites W2400607720 @default.
- W4386151686 cites W2429754450 @default.
- W4386151686 cites W2472807857 @default.
- W4386151686 cites W2518316517 @default.
- W4386151686 cites W2520423441 @default.
- W4386151686 cites W2525351830 @default.
- W4386151686 cites W2537449585 @default.
- W4386151686 cites W2539177344 @default.
- W4386151686 cites W2622643549 @default.
- W4386151686 cites W2752435500 @default.
- W4386151686 cites W2766783111 @default.
- W4386151686 cites W2778315707 @default.
- W4386151686 cites W2792066306 @default.
- W4386151686 cites W281347911 @default.
- W4386151686 cites W2888795824 @default.
- W4386151686 cites W2892141974 @default.
- W4386151686 cites W2892295719 @default.
- W4386151686 cites W2908463329 @default.
- W4386151686 cites W2933738638 @default.
- W4386151686 cites W2937428609 @default.
- W4386151686 cites W2942828241 @default.
- W4386151686 cites W2966582752 @default.
- W4386151686 cites W2970513804 @default.
- W4386151686 cites W3006914536 @default.
- W4386151686 cites W3007084158 @default.
- W4386151686 cites W3009342748 @default.
- W4386151686 cites W3024272062 @default.
- W4386151686 cites W3040512164 @default.
- W4386151686 cites W3044519401 @default.
- W4386151686 cites W3083886395 @default.
- W4386151686 cites W3090670424 @default.
- W4386151686 cites W3134505952 @default.
- W4386151686 cites W3146002984 @default.
- W4386151686 cites W3166839955 @default.
- W4386151686 cites W3199635621 @default.
- W4386151686 cites W3199710005 @default.
- W4386151686 cites W3201244536 @default.
- W4386151686 cites W3217316016 @default.
- W4386151686 cites W4213029075 @default.
- W4386151686 cites W4220662311 @default.
- W4386151686 cites W4220822244 @default.
- W4386151686 cites W4221084054 @default.
- W4386151686 cites W4224231032 @default.
- W4386151686 cites W4226343450 @default.
- W4386151686 cites W4290988839 @default.
- W4386151686 cites W4295083672 @default.
- W4386151686 cites W4302011971 @default.