Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386156714> ?p ?o ?g. }
- W4386156714 abstract "Abstract The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a many-to-many fashion, both within the same cell (in cis) and between cells (in trans), and their interactions are modulated by Fringe glycosyltransferases. A fundamental question is how the strength of Notch signaling depends on which pathway components are expressed, at what levels, and in which cells. Here, we used a quantitative, bottom-up, cell-based approach to systematically characterize trans-activation, cis-inhibition, and cis-activation signaling efficiencies across a range of ligand and Fringe expression levels in two mammalian cell types. Each ligand (Dll1, Dll4, Jag1, and Jag2) and receptor variant (Notch1 and Notch2) analyzed here exhibited a unique profile of interactions, Fringe-dependence, and signaling outcomes. All four ligands were able to bind receptors in cis and in trans, and all ligands trans-activated both receptors except for Jag1, which failed to activate Notch1. Cis-interactions were predominantly inhibitory, with the exception of the Dll1- and Dll4-Notch2 pairs, which exhibited cis-activation stronger than trans-activation. Lfng strengthened Delta-mediated trans-activation and weakened Jagged-mediated trans-activation for both receptors. Finally, cis-ligands showed diverse cis-inhibition strengths, which depended on the identity of the trans-ligand as well as the receptor. The map of receptor-ligand-Fringe interaction outcomes revealed here should help guide rational perturbation and control of the Notch pathway." @default.
- W4386156714 created "2023-08-26" @default.
- W4386156714 creator A5034545266 @default.
- W4386156714 creator A5084824254 @default.
- W4386156714 creator A5090684092 @default.
- W4386156714 date "2023-08-25" @default.
- W4386156714 modified "2023-10-18" @default.
- W4386156714 title "Diversity in Notch ligand-receptor signaling interactions" @default.
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- W4386156714 doi "https://doi.org/10.1101/2023.08.24.554677" @default.
- W4386156714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37662208" @default.
- W4386156714 hasPublicationYear "2023" @default.
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