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- W4386156747 abstract "Abstract Background Colorectal cancer (CRC) is one of the most common cancer types affecting both men and women. MicroRNA-492 (miR-492) plays an important role in the development of various malignant tumours; however, its specific role and related mechanisms in CRC development remain unclear. Hence, we aimed to explore the relationship between miR-492 and the prognosis of CRC patients and the specific mechanisms involved in the development of CRC. Methods The GSE29622 dataset was downloaded from the Gene Expression Omnibus database to analyse the relationship between the miR-492 expression level and the overall survival of patients with CRC. Forty-four pairs of primary CRC tissues and paired normal tissues were collected. The relationship between the miR-492 expression level and clinicopathological parameters of patients with CRC was analysed using a statistical method. MiRNA quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect miR-492 expression levels in CRC tissues and cell lines. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and colony formation assays were performed to assess cell growth and proliferation, respectively. Transwell assays were performed to analyse the migration and invasion potential of CRC cells. The interaction between miR-492 and three prime untranslated regions (3′-UTRs) of neuronal pentraxin 1 (NPTX1) was evaluated using a luciferase reporter assay. The expression of NPTX1 in CRC tissues and cells was detected by qRT-PCR. Results MiR-492 could recognise the 3′-UTR of NPTX1 mRNA and directly target and regulate NPTX1 expression, thereby promoting the growth, migration, and invasion of CRC cells. Conclusions The ability to mediate the biological behaviour of CRC by targeting NPTX1 makes miR-492 a potential prognostic marker and therapeutic target for CRC." @default.
- W4386156747 created "2023-08-26" @default.
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- W4386156747 date "2023-08-25" @default.
- W4386156747 modified "2023-10-04" @default.
- W4386156747 title "Investigating whether microRNA-492 promotes colorectal cancer cell growth, migration, and invasion by targeting neuronal pentraxin 1" @default.
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- W4386156747 doi "https://doi.org/10.21203/rs.3.rs-3178359/v1" @default.
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