Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386156780> ?p ?o ?g. }
- W4386156780 abstract "Members of the NSL histone acetyltransferase complex are involved in multiorgan developmental syndromes. While the NSL complex is known for its importance in early development, its role in fully differentiated cells remains enigmatic. Using a kidney-specific model, we discovered that deletion of NSL complex members KANSL2 or KANSL3 in postmitotic podocytes led to catastrophic kidney dysfunction. Systematic comparison of two primary differentiated cell types reveals the NSL complex as a master regulator of intraciliary transport genes in both dividing and nondividing cells. NSL complex ablation led to loss of cilia and impaired sonic hedgehog pathway in ciliated fibroblasts. By contrast, nonciliated podocytes responded with altered microtubule dynamics and obliterated podocyte functions. Finally, overexpression of wild-type but not a double zinc finger (ZF-ZF) domain mutant of KANSL2 rescued the transcriptional defects, revealing a critical function of this domain in NSL complex assembly and function. Thus, the NSL complex exhibits bifurcation of functions to enable diversity of specialized outcomes in differentiated cells." @default.
- W4386156780 created "2023-08-26" @default.
- W4386156780 creator A5003600914 @default.
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- W4386156780 creator A5036219600 @default.
- W4386156780 creator A5048410197 @default.
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- W4386156780 creator A5054875102 @default.
- W4386156780 creator A5059188391 @default.
- W4386156780 creator A5091002637 @default.
- W4386156780 date "2023-08-25" @default.
- W4386156780 modified "2023-10-14" @default.
- W4386156780 title "Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells" @default.
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